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Journal of Personalized Medicine, Volume 12, Issue 9

September 2022 - 187 articles

Cover Story: Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in many cases, gestational diabetes occurs in healthy nulliparous women with no obvious risk factors. Emerging data suggest that the tendency to develop gestational diabetes has genetic and environmental components. Here we develop a polygenic risk score for GDM and investigate relationships between its genetic architecture and genetically constructed risk factors and biomarkers. Our results demonstrate that the polygenic risk score can be used as an early screening tool that identifies women at higher risk of GDM before its onset allowing comprehensive monitoring and preventative programs to mitigate the risks. View this paper
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Articles (187)

  • Article
  • Open Access
7 Citations
3,706 Views
13 Pages

Computer-Aided Histopathological Characterisation of Endometriosis Lesions

  • Brett D. McKInnon,
  • Konstantinos Nirgianakis,
  • Lijuan Ma,
  • Carlos Alvarez Wotzkow,
  • Selina Steiner,
  • Fabian Blank and
  • Michael D. Mueller

16 September 2022

Endometriosis is a common gynaecological condition characterised by the growth of endometrial tissue outside the uterus and is associated with pain and infertility. Currently, the gold standard for endometriosis diagnosis is laparoscopic excision and...

  • Article
  • Open Access
2 Citations
2,098 Views
15 Pages

Impact of Race and Ethnicity on Presentation and Surgical Outcomes of Idiopathic Macular Holes

  • Matthew N. Parvus,
  • Abigail M. Louis,
  • Stephanie Trejo Corona,
  • Tien P. Wong,
  • James C. Major,
  • Sagar B. Patel and
  • Charles C. Wykoff

16 September 2022

There is limited data on the presentation and surgical outcomes of idiopathic macular holes (IMH) for different ethnic and racial groups. Recognition of distinct, clinically-relevant patient subgroups may provide opportunities to identify specific un...

  • Systematic Review
  • Open Access
21 Citations
3,192 Views
21 Pages

Direct-Acting Antivirals for HCV Treatment in Decompensated Liver Cirrhosis Patients: A Systematic Review and Meta-Analysis

  • JiHyun An,
  • Dong Ah Park,
  • Min Jung Ko,
  • Sang Bong Ahn,
  • Jeong-Ju Yoo,
  • Dae Won Jun and
  • Sun Young Yim

15 September 2022

DAA therapy is known to clear hepatitis C virus infection in patients with decompensated cirrhosis (DC). However, the safety and benefits of DAA in DC remain unclear, especially with the use of protease inhibitors (PI). Therefore, we evaluated the ef...

  • Review
  • Open Access
25 Citations
6,773 Views
21 Pages

Guided Endodontics: Static vs. Dynamic Computer-Aided Techniques—A Literature Review

  • Diana Ribeiro,
  • Eva Reis,
  • Joana A. Marques,
  • Rui I. Falacho and
  • Paulo J. Palma

15 September 2022

(1) Background: access cavity preparation is the first stage of non-surgical endodontic treatment. The inaccuracy of this step may lead to numerous intraoperative complications, which impair the root canal treatment’s prognosis and therefore th...

  • Feature Paper
  • Article
  • Open Access
5 Citations
2,936 Views
10 Pages

Muscle-in-Vein Conduits for the Treatment of Symptomatic Neuroma of Sensory Digital Nerves

  • Ines Ana Ederer,
  • Jonas Kolbenschlag,
  • Adrien Daigeler and
  • Theodora Wahler

15 September 2022

Background: Considering the debilitating burden of neuroma resulting in a significant loss of function and excruciating pain, the use of muscle-in-vein conduits (MVCs) for the reconstruction of painful neuroma of sensory nerves of the fingers was ass...

  • Review
  • Open Access
75 Citations
9,762 Views
25 Pages

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

  • Javad Sharifi-Rad,
  • Simona Rapposelli,
  • Simona Sestito,
  • Jesús Herrera-Bravo,
  • Alejandra Arancibia-Diaz,
  • Luis A. Salazar,
  • Balakyz Yeskaliyeva,
  • Ahmet Beyatli,
  • Gerardo Leyva-Gómez and
  • Carlos González-Contreras
  • + 3 authors

15 September 2022

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence of Aβ-amyloid...

  • Article
  • Open Access
13 Citations
3,498 Views
9 Pages

Correlations between Peak Nasal Inspiratory Flow, Acoustic Rhinometry, 4-Phase Rhinomanometry and Reported Nasal Symptoms

  • Giancarlo Ottaviano,
  • Alfonso Luca Pendolino,
  • Bruno Scarpa,
  • Miriam Torsello,
  • Daniele Sartori,
  • Enrico Savietto,
  • Elena Cantone and
  • Piero Nicolai

15 September 2022

Background: Rhinomanometry, acoustic rhinometry (AR) and peak nasal inspiratory flow (PNIF) are popular methods for nasal patency evaluation. The aim of the present study was to compare these three methods with the reported nasal symptoms to determin...

  • Article
  • Open Access
3 Citations
2,685 Views
13 Pages

The Interplay of PR Interval and AV Pacing Delays Used for Cardiac Resynchronization Therapy in Heart Failure Patients: Association with Clinical Response in a Retrospective Analysis of a Large Observational Study

  • Maurizio Gasparini,
  • Mauro Biffi,
  • Maurizio Landolina,
  • Giuseppe Cattafi,
  • Roberto Rordorf,
  • Giovanni Luca Botto,
  • Giovanni Battista Forleo,
  • Giovanni Morani,
  • Luca Santini and
  • Antonio Dello Russo
  • + 5 authors

15 September 2022

Background. Cardiac resynchronization therapy (CRT) is a treatment for heart failure (HF) patients with prolonged QRS and impaired left ventricular (LV) systolic function. We aim to evaluate how the baseline PR interval is associated with outcomes (a...

  • Article
  • Open Access
9 Citations
3,108 Views
12 Pages

Understanding the Patient Experience of Receiving Clinically Actionable Genetic Results from the MyCode Community Health Initiative, a Population-Based Genomic Screening Initiative

  • Anna Baker,
  • Kasia Tolwinski,
  • Jamie Atondo,
  • F. Daniel Davis,
  • Jessica Goehringer,
  • Laney K. Jones,
  • Cassandra J. Pisieczko,
  • Amy C. Sturm,
  • Janet L. Williams and
  • Marc S. Williams
  • + 2 authors

15 September 2022

Understanding unselected individuals’ experiences receiving genetic results through population genomic screening is critical to advancing clinical utility and improving population health. We conducted qualitative interviews with individuals who...

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J. Pers. Med. - ISSN 2075-4426