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Journal of Personalized Medicine, Volume 12, Issue 9

September 2022 - 187 articles

Cover Story: Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in many cases, gestational diabetes occurs in healthy nulliparous women with no obvious risk factors. Emerging data suggest that the tendency to develop gestational diabetes has genetic and environmental components. Here we develop a polygenic risk score for GDM and investigate relationships between its genetic architecture and genetically constructed risk factors and biomarkers. Our results demonstrate that the polygenic risk score can be used as an early screening tool that identifies women at higher risk of GDM before its onset allowing comprehensive monitoring and preventative programs to mitigate the risks. View this paper
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Articles (187)

  • Article
  • Open Access
10 Citations
6,222 Views
9 Pages

A Meta-Analysis on the Effectiveness of Sertaconazole 2% Cream Compared with Other Topical Therapies for Seborrheic Dermatitis

  • Simona Roxana Georgescu,
  • Cristina Iulia Mitran,
  • Madalina Irina Mitran,
  • Andreea Amuzescu,
  • Clara Matei and
  • Mircea Tampa

19 September 2022

Seborrheic dermatitis (SD) is a relapsing inflammatory skin disorder that affects the seborrheic areas of the body. Its etiology is not completely elucidated; however, the link between disease exacerbations and the proliferation of Malassezia spp., a...

  • Systematic Review
  • Open Access
8 Citations
2,705 Views
16 Pages

19 September 2022

Previous systematic reviews have reported that coronally advanced flap (CAF) + connective tissue graft (CTG) are the gold standard in root coverage procedures (RCP). Nevertheless, adjunctive treatment with hyaluronic acid (HA) has been proposed to ai...

  • Review
  • Open Access
19 Citations
3,949 Views
14 Pages

Neuromuscular Blockade in the Pre- and COVID-19 ARDS Patients

  • Vasiliki Tsolaki,
  • George E. Zakynthinos,
  • Maria-Eirini Papadonta,
  • Fotini Bardaka,
  • George Fotakopoulos,
  • Ioannis Pantazopoulos,
  • Demosthenes Makris and
  • Epaminondas Zakynthinos

19 September 2022

Acute respiratory distress syndrome (ARDS) accounts for a quarter of mechanically ventilated patients, while during the pandemic, it overwhelmed the capacity of intensive care units (ICUs). Lung protective ventilation (low tidal volume, positive-end...

  • Article
  • Open Access
7 Citations
3,778 Views
11 Pages

Effects of Oral Supplementation with Myo-Inositol and D-Chiro-Inositol on Ovarian Functions in Female Long-Term Survivors of Lymphoma: Results from a Prospective Case–Control Analysis

  • Miriam Dellino,
  • Eliano Cascardi,
  • Claudia Leoni,
  • Francesca Fortunato,
  • Annarita Fusco,
  • Raffaele Tinelli,
  • Gerardo Cazzato,
  • Salvatore Scacco,
  • Antonio Gnoni and
  • Antonio Scilimati
  • + 9 authors

19 September 2022

The progressive improvement of lymphoma treatment has led to an important prolongation of patient survival and life expectancy. The principal international scientific societies of oncology now therefore recommend that long-term survivors of lymphoma...

  • Article
  • Open Access
6 Citations
3,106 Views
12 Pages

Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1/T2 Tongue Cancer

  • Andrea Iandelli,
  • Filippo Marchi,
  • An-Chieh Chen,
  • Chi-Kuan Young,
  • Chun-Ta Liao,
  • Chung-Kan Tsao,
  • Chung-Jan Kang,
  • Hung-Ming Wang,
  • Tung-Chieh Joseph Chang and
  • Shiang-Fu Huang

19 September 2022

Background: Patients affected by oral tongue squamous cell carcinoma (OTSCC) underwent a supraomohyoid neck dissection (SOHND) or modified radical neck dissection (mRND) according to the clinical nodal status (cN0 vs. cN+). We investigate whether the...

  • Article
  • Open Access
12 Citations
4,211 Views
9 Pages

Management of Inadvertent Arterial Catheterization during Central Venous Catheter Placement: A Case Series

  • Georgios Papastratigakis,
  • Diamantina Marouli,
  • Athanasia Proklou,
  • Nikolaos Nasis,
  • Eumorfia Kondili and
  • Elias Kehagias

19 September 2022

Percutaneous central venous catheterization, although a widely used technique in ICU patients worldwide, is not devoid of complications even under real-time ultrasound guidance. Arterial puncture is a well-recognized complication, while unintended su...

  • Article
  • Open Access
47 Citations
3,120 Views
10 Pages

Surgery for T4 Colorectal Cancer in Older Patients: Determinants of Outcomes

  • Michael Osseis,
  • William A Nehmeh,
  • Nathalie Rassy,
  • Joseph Derienne,
  • Roger Noun,
  • Chady Salloum,
  • Elie Rassy,
  • Stergios Boussios and
  • Daniel Azoulay

19 September 2022

Background: This study aimed to compare the outcomes of older and younger patients with T4 colorectal cancer (CRC) treated with surgery. Methods: Consecutive patients with T4 CRC treated surgically at Henri Mondor Hospital between 2008 and 2016 were...

  • Article
  • Open Access
25 Citations
2,707 Views
8 Pages

Prepectoral vs. Submuscular Immediate Breast Reconstruction in Patients Undergoing Mastectomy after Neoadjuvant Chemotherapy: Our Early Experience

  • Lorenzo Scardina,
  • Alba Di Leone,
  • Ersilia Biondi,
  • Beatrice Carnassale,
  • Alejandro Martin Sanchez,
  • Sabatino D’Archi,
  • Antonio Franco,
  • Francesca Moschella,
  • Stefano Magno and
  • Daniela Terribile
  • + 8 authors

19 September 2022

Background: Conservative mastectomy with immediate prosthetic breast reconstruction (IPBR) is an oncologically accepted technique that offers improved esthetic results and patient quality of life. Traditionally, implants have been placed in a submusc...

  • Article
  • Open Access
6 Citations
4,069 Views
16 Pages

18 September 2022

The aim of this retrospective study was to evaluate the medium-term clinical and functional outcomes of patients with closed, displaced, and unstable, simple or complex, intra- and extra-articular distal radius fractures (DRFs) treated with a bridgin...

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J. Pers. Med. - ISSN 2075-4426