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Journal of Personalized Medicine, Volume 12, Issue 9

September 2022 - 187 articles

Cover Story: Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. A variety of risk factors, such as BMI and age, have been associated with increased risks of gestational diabetes. However, in many cases, gestational diabetes occurs in healthy nulliparous women with no obvious risk factors. Emerging data suggest that the tendency to develop gestational diabetes has genetic and environmental components. Here we develop a polygenic risk score for GDM and investigate relationships between its genetic architecture and genetically constructed risk factors and biomarkers. Our results demonstrate that the polygenic risk score can be used as an early screening tool that identifies women at higher risk of GDM before its onset allowing comprehensive monitoring and preventative programs to mitigate the risks. View this paper
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Articles (187)

  • Review
  • Open Access
9 Citations
3,486 Views
14 Pages

Application of Reactive Oxygen Species in Dental Treatment

  • Chiaki Komine,
  • Satoshi Uchibori,
  • Osamu Tsudukibashi and
  • Yasuhisa Tsujimoto

18 September 2022

Reactive oxygen species (ROS) and free radicals, which have been implicated in inflammation, pain, carcinogenesis, and aging, are actually used in dental treatments such as tooth bleaching and composite resin polymerization. Recently, numerous studie...

  • Article
  • Open Access
10 Citations
2,790 Views
11 Pages

Feasibility of Neovessel Embolization in a Large Animal Model of Tendinopathy: Safety and Efficacy of Various Embolization Agents

  • Julien Ghelfi,
  • Ian Soulairol,
  • Olivier Stephanov,
  • Marylène Bacle,
  • Hélène de Forges,
  • Noelia Sanchez-Ballester,
  • Gilbert Ferretti,
  • Jean-Paul Beregi and
  • Julien Frandon

18 September 2022

Targeting neovessels in chronic tendinopathies has emerged as a new therapeutic approach and several embolization agents have been reported. The aim of this study was to investigate the feasibility of embolization with different agents in a porcine m...

  • Article
  • Open Access
11 Citations
3,463 Views
9 Pages

Risk Factors for Acute Postoperative Delirium in Cardiac Surgery Patients >65 Years Old

  • Eleni Spiropoulou,
  • George Samanidis,
  • Meletios Kanakis and
  • Ioannis Nenekidis

18 September 2022

Background: Acute postoperative delirium is the most common neuropsychiatric disorder in cardiac surgery patients in the intensive care unit (ICU). The purpose of this study was to evaluate the possible risk factors of postoperative delirium (POD) fo...

  • Review
  • Open Access
8 Citations
4,526 Views
14 Pages

Clinical Markers of Need for Surgery in Orbital Complication of Acute Rhinosinusitis in Children: Overview and Systematic Review

  • Elena Cantone,
  • Eva Piro,
  • Eugenio De Corso,
  • Claudio Di Nola,
  • Stefano Settimi,
  • Giusi Grimaldi and
  • Gaetano Motta

18 September 2022

Background: Although they can occur at all ages, orbital (OC) and periorbital cellulitis (POC) prevail in the pediatric population. Acute rhinosinusitis (ARS) is the most frequent predisposing factor of OC. Recent literature has suggested a medical m...

  • Article
  • Open Access
50 Citations
4,800 Views
9 Pages

Effectiveness of Dupilumab in the Treatment of Patients with Uncontrolled Severe CRSwNP: A “Real-Life” Observational Study in Naïve and Post-Surgical Patients

  • Giancarlo Ottaviano,
  • Tommaso Saccardo,
  • Giuseppe Roccuzzo,
  • Riccardo Bernardi,
  • Alessandra Di Chicco,
  • Alfonso Luca Pendolino,
  • Bruno Scarpa,
  • Edoardo Mairani and
  • Piero Nicolai

17 September 2022

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) represents 25–30% of all CRS cases, and in the most severe forms it is associated with a poor quality of life and a high rate of nasal polyps’ recurrence after surgery. Dupilum...

  • Feature Paper
  • Article
  • Open Access
7 Citations
2,735 Views
7 Pages

17 September 2022

Not all hospitals have interventional radiology services. This fact implies that in centers where this resource is not available, the treatment of stroke in the acute phase must be adapted and individualized. The aim of the study is to determine and...

  • Case Report
  • Open Access
2 Citations
3,030 Views
14 Pages

Possible Use of Minocycline in Adjunction to Intranasal Esketamine for the Management of Difficult to Treat Depression following Extensive Pharmacogenomic Testing: Two Case Reports

  • Matteo Marcatili,
  • Riccardo Borgonovo,
  • Noemi Cimminiello,
  • Ranieri Domenico Cornaggia,
  • Giulia Casati,
  • Cristian Pellicioli,
  • Laura Maggioni,
  • Federico Motta,
  • Chiara Redaelli and
  • Luisa Ledda
  • + 18 authors

16 September 2022

The advent of intra-nasal esketamine (ESK), one of the first so called fast-acting antidepressant, promises to revolutionize the management of treatment resistant depression (TRD). This NMDA receptor antagonist has proven to be rapidly effective in t...

  • Review
  • Open Access
11 Citations
3,632 Views
16 Pages

Immune Cells in Head-and-Neck Tumor Microenvironments

  • Enar Jumaniyazova,
  • Anastasiya Lokhonina,
  • Dzhuliia Dzhalilova,
  • Anna Kosyreva and
  • Timur Fatkhudinov

16 September 2022

Head-and-neck cancers constitute a heterogeneous group of aggressive tumors with high incidence and low survival rates, collectively being the sixth most prevalent cancer type globally. About 90% of head-and-neck cancers are classified as squamous ce...

  • Article
  • Open Access
5 Citations
2,239 Views
13 Pages

Machine Learning Algorithms for Prediction of Survival by Stress Echocardiography in Chronic Coronary Syndromes

  • Lauro Cortigiani,
  • Danila Azzolina,
  • Quirino Ciampi,
  • Giulia Lorenzoni,
  • Nicola Gaibazzi,
  • Fausto Rigo,
  • Sonia Gherardi,
  • Francesco Bovenzi,
  • Dario Gregori and
  • Eugenio Picano

16 September 2022

Stress echocardiography (SE) is based on regional wall motion abnormalities and coronary flow velocity reserve (CFVR). Their independent prognostic capabilities could be better studied with a machine learning (ML) approach. The study aims to assess t...

  • Editorial
  • Open Access
3 Citations
1,882 Views
3 Pages

16 September 2022

The coronavirus disease 2019 (COVID-19) pandemic has placed a great burden on healthcare systems worldwide. COVID-19 clinical prediction models are needed to relieve the burden of the pandemic on healthcare systems. In the absence of COVID-19 clinica...

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J. Pers. Med. - ISSN 2075-4426