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Journal of Personalized Medicine, Volume 12, Issue 7

July 2022 - 174 articles

Cover Story: Although several vaccines and specific antiviral agents have been developed for COVID-19 prevention and treatment, some patients still progress to severe illness. Herein, specific molecular and computational approaches are needed for identifying key genes and novel biomarkers related to immune-inducted severe COVID-19. Moreover, finding candidate drugs targeting the key genes is necessary to treat severe COVID-19 patients precisely. This study conducted multi-level biological network analysis, such as protein-protein interaction (PPI), gene regulatory, and drug-gene interaction network, to discover immune-related key genes, biomarkers, and candidate drugs based on severe COVID-19 patient leukocyte transcriptomic profiles. Structural-based drug repurposing was also carried out to find potential drugs. This study has shed light on bioinformatics and systems biology to precision medicine. View this paper
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Articles (174)

  • Article
  • Open Access
3 Citations
2,795 Views
13 Pages

The Association between Muscle Quantity and Overall Survival Depends on Muscle Radiodensity: A Cohort Study in Non-Small-Cell Lung Cancer Patients

  • Wouter A. C. van Amsterdam,
  • Netanja I. Harlianto,
  • Joost J. C. Verhoeff,
  • Pim Moeskops,
  • Pim A. de Jong and
  • Tim Leiner

21 July 2022

The prognostic value of CT-derived muscle quantity for overall survival (OS) in patients with non-small-cell lung cancer (NSCLC) is uncertain due to conflicting evidence. We hypothesize that increased muscle quantity is associated with better OS in p...

  • Article
  • Open Access
1 Citations
2,488 Views
19 Pages

Potential Similarities in Sex Difference in Key Genes and Their Expression, Network, EQTL and Pathways between COVID-19 and Chronic Kidney Disease Based on Mouse Model

  • Zhuo Yu,
  • Jingyu Zhan,
  • Wei Dong,
  • Lu Lu,
  • Monica M. Jablonski,
  • Lotfi Aleya,
  • Jingyu Chen,
  • Peiqing Zhang,
  • Hong Chen and
  • Weikuan Gu

21 July 2022

COVID-19 and chronic kidney disease (CKD) share similarity in sex bias and key genes in the disease pathway of sex difference. We investigated the sex difference of molecular pathways of four key players of these two diseases using an existing large...

  • Article
  • Open Access
4 Citations
3,037 Views
9 Pages

Risk of Tuberculosis Caused by Fluticasone Propionate versus Budesonide in Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Study

  • Iseul Yu,
  • Sunmin Park,
  • Se Hwa Hong,
  • Min-Seok Chang,
  • Seok Jeong Lee,
  • Suk Joong Yong,
  • Won-Yeon Lee,
  • Sang-Ha Kim and
  • Ji-Ho Lee

21 July 2022

Background: In chronic obstructive pulmonary disease (COPD), inhaled corticosteroids (ICSs) are recommended for use by patients with frequent exacerbations and blood eosinophilia. However, ICSs are often inappropriately prescribed and overused. COPD...

  • Systematic Review
  • Open Access
25 Citations
4,752 Views
26 Pages

Effect of Exercise on Inflammation in Hemodialysis Patients: A Systematic Review

  • Erika Meléndez Oliva,
  • Jorge H. Villafañe,
  • Jose Luis Alonso Pérez,
  • Alexandra Alonso Sal,
  • Guillermo Molinero Carlier,
  • Andrés Quevedo García,
  • Silvia Turroni,
  • Oliver Martínez-Pozas,
  • Norberto Valcárcel Izquierdo and
  • Eleuterio A. Sánchez Romero

21 July 2022

Background: In recent years, physical exercise has been investigated for its potential as a therapeutic tool in patients with end-stage renal disease (ESRD) undergoing hemodialysis maintenance treatment (HD). It has been shown that regular practice o...

  • Article
  • Open Access
7 Citations
4,133 Views
10 Pages

CYP2C19 and CYP2D6 Genotypes and Metabolizer Status Distribution in a Bulgarian Psychiatric Cohort

  • Hristo Y. Ivanov,
  • Denitsa Grigorova,
  • Volker M. Lauschke,
  • Branimir Velinov,
  • Kaloyan Stoychev,
  • Gergana Kyosovska and
  • Peter Shopov

21 July 2022

CYP2D6 and CYP2C19 are enzymes of essential significance for the pharmacokinetics of a multitude of commonly used antidepressants, antipsychotics, antiemetics, β-blockers, opioids, antiestrogen, antacids, etc. Polymorphisms in the respective gen...

  • Article
  • Open Access
1 Citations
2,148 Views
12 Pages

Association between Age of Onset of Hypertension and Incident Atrial Fibrillation

  • Yonggu Lee,
  • Jeong-Hun Shin,
  • Byung Sik Kim,
  • Hyungdon Kook,
  • Woohyeun Kim,
  • Ran Heo,
  • Young-Hyo Lim,
  • Jinho Shin,
  • Chun Ki Kim and
  • Jin-Kyu Park

21 July 2022

We investigated whether age at hypertension (HTN) onset was associated with the risk of atrial fibrillation (AF) in the general population. This prospective longitudinal community-based cohort study included 9892 participants without AF at baseline,...

  • Article
  • Open Access
7 Citations
3,353 Views
12 Pages

MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction

  • Ascensión M. de los Reyes-García,
  • José Miguel Rivera-Caravaca,
  • Laura Zapata-Martínez,
  • Sonia Águila,
  • Andrea Véliz-Martínez,
  • Nuria García-Barberá,
  • Pablo Gil-Perez,
  • Pedro J. Guijarro-Carrillo,
  • Esteban Orenes-Piñero and
  • Cecilia López-García
  • + 4 authors

20 July 2022

Studies on older patients have established notable conceptual changes in the etiopathogenesis of acute coronary syndrome (ACS), but little is known about this disease in young patients (<45 years). Of special interest is thromboinflammation, key a...

  • Article
  • Open Access
1 Citations
2,813 Views
10 Pages

COPD, but Not Asthma, Is Associated with Worse Outcomes in COVID-19: Real-Life Data from Four Main Centers in Northwest Italy

  • Stefania Nicola,
  • Richard Borrelli,
  • Irene Ridolfi,
  • Virginia Bernardi,
  • Paolo Borrelli,
  • Giuseppe Guida,
  • Andrea Antonelli,
  • Carlo Albera,
  • Stefania Marengo and
  • Antonio Briozzo
  • + 12 authors

20 July 2022

Introduction: Asthma, along with inhaled steroids, was initially considered a risk factor for worse clinical outcomes in COVID-19. This was related to the higher morbidity observed in asthma patients during previous viral outbreaks. This retrospectiv...

  • Article
  • Open Access
3 Citations
2,334 Views
9 Pages

Changes in the Incidence of Cardiovascular Diseases during the COVID-19 Pandemic in Korea

  • Hyo Geun Choi,
  • Dae Myoung Yoo,
  • Yoo Hwan Kim,
  • Mi Jung Kwon,
  • Joo-Hee Kim,
  • Joon Ho Song and
  • Ji Hee Kim

20 July 2022

There is scarcity in the evidence addressing the indirect impact of the COVID-19 pandemic on the epidemiology of CVDs. In this study we aimed to examine possible changes in the incidence of CVDs in Korea during the COVID-19 pandemic. ICD-10 codes of...

  • Review
  • Open Access
1 Citations
2,861 Views
10 Pages

The Medical, Clinical, and Radiographic Aspects of Multiple Idiopathic Tooth Resorption: A Systematic Review

  • Raphaël Richert,
  • Julie Santamaria,
  • Laurent Laforest and
  • Jean-Christophe Maurin

20 July 2022

Background: Many causes of resorption remain unclear and are thus identified as idiopathic. In such cases, management is difficult, especially when multiple teeth are involved. The aim of the present study was to assess the literature regarding the m...

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J. Pers. Med. - ISSN 2075-4426