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Diagnostics, Volume 12, Issue 4

April 2022 - 249 articles

Cover Story: Personalized diagnosis for thyroid nodules benefits from a combination of imagery and molecular biomarkers, as well as artificial intelligence algorithms, which are used more and more in our timeline. Functional imaging diagnosis such as SPECT, PET, or fused images (SPECT/CT, PET/CT, PET/MRI), is exploited at maximum in thyroid nodules, with a long history in the past and a bright future with many suitable radiotracers that could properly contribute to diagnosing malignancy in thyroid nodules. In this way, patients will be spared from surgery complications, and apparently more expensive diagnostic workouts will financially compensate each patient and also the healthcare system. For those in need of personalized therapeutic management, PRRT and gene therapies are in continuous development supporting thyroid carcinoma’s treatment gap. View this paper
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Articles (249)

  • Review
  • Open Access
7 Citations
6,707 Views
34 Pages

Nucleic Acid Biomarkers in Waldenström Macroglobulinemia and IgM-MGUS: Current Insights and Clinical Relevance

  • Daniela Drandi,
  • Philippe Decruyenaere,
  • Martina Ferrante,
  • Fritz Offner,
  • Jo Vandesompele and
  • Simone Ferrero

Waldenström Macroglobulinemia (WM) is an indolent lymphoplasmacytic lymphoma, characterized by the production of excess immunoglobulin M monoclonal protein. WM belongs to the spectrum of IgM gammopathies, ranging from asymptomatic IgM monoclonal...

  • Article
  • Open Access
6 Citations
3,272 Views
17 Pages

Colonoscopy is the gold standard to detect colon polyps prematurely. Early detection, characterization and resection of polyps decrease colon cancer incidence. Colon polyp missing rate remains high despite novel methods development. Narrowed-band ima...

  • Article
  • Open Access
10 Citations
4,454 Views
16 Pages

Automated 3D Segmentation of the Aorta and Pulmonary Artery on Non-Contrast-Enhanced Chest Computed Tomography Images in Lung Cancer Patients

  • Hao-Jen Wang,
  • Li-Wei Chen,
  • Hsin-Ying Lee,
  • Yu-Jung Chung,
  • Yan-Ting Lin,
  • Yi-Chieh Lee,
  • Yi-Chang Chen,
  • Chung-Ming Chen and
  • Mong-Wei Lin

Pulmonary hypertension should be preoperatively evaluated for optimal surgical planning to reduce surgical risk in lung cancer patients. Preoperative measurement of vascular diameter in computed tomography (CT) images is a noninvasive prediction meth...

  • Case Report
  • Open Access
5 Citations
6,237 Views
6 Pages

Rectal Polyposis in Mucosal Prolapse Syndrome

  • Yin Ping Wong,
  • Connie Kabincong,
  • Mohd Faisal Jabar and
  • Geok Chin Tan

Mucosal prolapse syndrome is also known as solitary rectal ulcer syndrome. It may either presents as an ulcer or polyp, which could mimic other pathological lesions such as juvenile polyp, hyperplastic polyp, adenomatous polyp, polyp related inflamma...

  • Systematic Review
  • Open Access
10 Citations
2,901 Views
12 Pages

The Need for Standardization in Next-Generation Sequencing Studies for Classic Hodgkin Lymphoma: A Systematic Review

  • Antonio Santisteban-Espejo,
  • Irene Bernal-Florindo,
  • Jose Perez-Requena,
  • Lidia Atienza-Cuevas,
  • Julia Moran-Sanchez,
  • María del Carmen Fernandez-Valle,
  • Raquel Romero-Garcia and
  • Marcial Garcia-Rojo

Classic Hodgkin lymphoma (cHL) constitutes a B cell-derived neoplasm defined by a scarce tumoral population, termed Hodgkin and Reed–Sternberg (HRS) cells, submerged into a histologically heterogeneous microenvironment. The paucity of HRS cells...

  • Article
  • Open Access
8 Citations
3,378 Views
11 Pages

Validation of the 30-Year Framingham Risk Score in a German Population-Based Cohort

  • Susanne Rospleszcz,
  • Fabian Starnecker,
  • Birgit Linkohr,
  • Moritz von Scheidt,
  • Christian Gieger,
  • Heribert Schunkert and
  • Annette Peters

The Framingham Risk Score to predict 30-year risk (FRS30y) of cardiovascular disease (CVD) constitutes an important tool for long-term risk prediction. However, due to its complex statistical properties and the paucity of large population-based cohor...

  • Article
  • Open Access
2 Citations
2,297 Views
10 Pages

Histological Diagnostic Yield and Clinical Significance of the First Biopsy in Device-Assisted Enteroscopy in Patients with Small Bowel Diseases: A KASID Multicenter Study

  • Hyeon Jeong Goong,
  • Tae Joon Kim,
  • Kwangwoo Nam,
  • Jihye Park,
  • Jin-Oh Kim,
  • Hyun Gun Kim,
  • Bong Min Ko,
  • Seong Ran Jeon and
  • Small Intestine Research Group of the Korean Association for the Study of Intestinal Diseases (KASID)

Device-assisted enteroscopy (DAE) enables the direct visualization of small bowel lesions with histological diagnosis; however, few studies have described the diagnostic performance of enteroscopic biopsy. We investigated the diagnostic performance o...

  • Review
  • Open Access
18 Citations
5,943 Views
22 Pages

Non-Invasive Assessment of Congestion by Cardiovascular and Pulmonary Ultrasound and Biomarkers in Heart Failure

  • Adriana Mihaela Ilieșiu,
  • Andreea Simona Hodorogea,
  • Ana-Maria Balahura and
  • Elisabeta Bădilă

Worsening chronic heart failure (HF) is responsible for recurrent hospitalization and increased mortality risk after discharge, irrespective to the ejection fraction. Symptoms and signs of pulmonary and systemic congestion are the most common cause f...

  • Review
  • Open Access
22 Citations
14,947 Views
24 Pages

MR Imaging of Pediatric Brain Tumors

  • Alok Jaju,
  • Kristen W. Yeom and
  • Maura E. Ryan

Primary brain tumors are the most common solid neoplasms in children and a leading cause of mortality in this population. MRI plays a central role in the diagnosis, characterization, treatment planning, and disease surveillance of intracranial tumors...

  • Review
  • Open Access
32 Citations
4,864 Views
17 Pages

The New Entity of Subacute Thyroiditis amid the COVID-19 Pandemic: From Infection to Vaccine

  • Mihaela Popescu,
  • Adina Ghemigian,
  • Corina Maria Vasile,
  • Andrei Costache,
  • Mara Carsote and
  • Alice Elena Ghenea

This is a review of full-length articles strictly concerning subacute thyroiditis (SAT) in relation to the SARS-CoV-2 virus infection (SVI) and COVID-19 vaccine (COV) that were published between the 1st of March 2020 and the 21st of March 2022 in Pub...

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Diagnostics - ISSN 2075-4418