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Diagnostics, Volume 12, Issue 4

April 2022 - 249 articles

Cover Story: Personalized diagnosis for thyroid nodules benefits from a combination of imagery and molecular biomarkers, as well as artificial intelligence algorithms, which are used more and more in our timeline. Functional imaging diagnosis such as SPECT, PET, or fused images (SPECT/CT, PET/CT, PET/MRI), is exploited at maximum in thyroid nodules, with a long history in the past and a bright future with many suitable radiotracers that could properly contribute to diagnosing malignancy in thyroid nodules. In this way, patients will be spared from surgery complications, and apparently more expensive diagnostic workouts will financially compensate each patient and also the healthcare system. For those in need of personalized therapeutic management, PRRT and gene therapies are in continuous development supporting thyroid carcinoma’s treatment gap. View this paper
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Articles (249)

  • Article
  • Open Access
2 Citations
2,671 Views
11 Pages

Association between the Concentrations of Essential and Toxic Elements in Mid-Trimester Amniotic Fluid and Fetal Chromosomal Abnormalities in Pregnant Polish Women

  • Joanna Suliburska,
  • Jakub Pankiewicz,
  • Adam Sajnóg,
  • Magdalena Paczkowska,
  • Beata Nowakowska,
  • Ewa Bakinowska,
  • Danuta Barałkiewicz and
  • Rafał Kocyłowski

The present study aimed to investigate the relationship between the concentrations of essential and toxic elements present in the amniotic fluid (AF) and fetal chromosomal abnormalities in pregnant women. A total of 156 pregnant white Polish women ag...

  • Review
  • Open Access
84 Citations
14,176 Views
12 Pages

Cell-Free DNA Fragmentomics in Liquid Biopsy

  • Spencer C. Ding and
  • Y.M. Dennis Lo

Cell-free DNA (cfDNA) in bodily fluids has rapidly transformed the development of noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma cfDNA consists of a mixture of molecules originating from various bodily tiss...

  • Review
  • Open Access
34 Citations
7,672 Views
14 Pages

Pituitary adenomas (PAs) are benign lesions; nonetheless, some PAs exhibit aggressive behaviors, which lead to recurrence. The impact of pituitary dysfunction, invasion-related risks, and other complications considerably affect the quality of life of...

  • Article
  • Open Access
2,481 Views
9 Pages

Predictive Variables for Interventional Angiography among Patients with Knee Hemarthrosis

  • Sang-Hun Ko,
  • Kwang-Hwan Jung,
  • Jae-Ryong Cha and
  • Ki-Bong Park

Studies regarding the variables that could predict the success of conservative treatment for knee hemarthrosis are lacking. This retrospective study evaluated the laboratory variables of patients who had unsatisfactory results from conservative treat...

  • Article
  • Open Access
30 Citations
4,350 Views
13 Pages

Development of an Interactive AI System for the Optimal Timing Prediction of Successful Weaning from Mechanical Ventilation for Patients in Respiratory Care Centers

  • Kuang-Ming Liao,
  • Shian-Chin Ko,
  • Chung-Feng Liu,
  • Kuo-Chen Cheng,
  • Chin-Ming Chen,
  • Mei-I Sung,
  • Shu-Chen Hsing and
  • Chia-Jung Chen

Successful weaning from prolonged mechanical ventilation (MV) is an important issue in respiratory care centers (RCCs). Delayed or premature extubation increases both the risk of adverse outcomes and healthcare costs. However, the accurate evaluation...

  • Article
  • Open Access
14 Citations
3,792 Views
9 Pages

Unusual N Gene Dropout and Ct Value Shift in Commercial Multiplex PCR Assays Caused by Mutated SARS-CoV-2 Strain

  • Petros Bozidis,
  • Eleni T. Tsaousi,
  • Charilaos Kostoulas,
  • Prodromos Sakaloglou,
  • Athanasia Gouni,
  • Despoina Koumpouli,
  • Hercules Sakkas,
  • Ioannis Georgiou and
  • Konstantina Gartzonika

Several SARS-CoV-2 variants have emerged and early detection for monitoring their prevalence is crucial. Many identification strategies have been implemented in cases where sequencing data for confirmation is pending or not available. The presence of...

  • Brief Report
  • Open Access
5 Citations
2,541 Views
7 Pages

Placental Ultrasonographical Findings during SARS-CoV-2 Infection

  • Sotirios Sotiriou,
  • Athina A. Samara,
  • Iokasti-Apostolia Tsiamalou,
  • Christos Donoudis,
  • Eleni Seviloglou,
  • Chara Skentou,
  • Antonios Garas and
  • Alexandros Daponte

Infection with SARS-CoV-2 virus (COVID-19) during pregnancy has been associated with several complications. Increasing evidence suggests that COVID-19 infection leaves tell-tale signs of placental injury. During ultrasound examination and placental e...

  • Article
  • Open Access
8 Citations
3,480 Views
16 Pages

Smartphone-Enabled versus Conventional Otoscopy in Detecting Middle Ear Disease: A Meta-Analysis

  • Chih-Hao Chen,
  • Chii-Yuan Huang,
  • Hsiu-Lien Cheng,
  • Heng-Yu Haley Lin,
  • Yuan-Chia Chu,
  • Chun-Yu Chang,
  • Ying-Hui Lai,
  • Mao-Che Wang and
  • Yen-Fu Cheng

Traditional otoscopy has some limitations, including poor visualization and inadequate time for evaluation in suboptimal environments. Smartphone-enabled otoscopy may improve examination quality and serve as a potential diagnostic tool for middle ear...

  • Article
  • Open Access
12 Citations
4,851 Views
18 Pages

COVID-19 in Tunisia (North Africa): Seroprevalence of SARS-CoV-2 in the General Population of the Capital City Tunis

  • Ines Cherif,
  • Ghassen Kharroubi,
  • Sana Chaabane,
  • Rihab Yazidi,
  • Mongi Dellagi,
  • Mohamed Ali Snoussi,
  • Sadok Salem,
  • Soumaya Marzouki,
  • Wafa Kammoun Rebai and
  • Samia Rourou
  • + 5 authors

Seroprevalence studies are essential to get an accurate estimate of the actual SARS-CoV-2 diffusion within populations. We report on the findings of the first serosurvey conducted in Tunis prior to the implementation of mass vaccination and analyzed...

  • Article
  • Open Access
6 Citations
3,557 Views
15 Pages

Endometrium as Control of Endometriosis in Experimental Research: Assessment of Sample Suitability

  • Vince Szegeczki,
  • László Fazekas,
  • Máté Kulcsár,
  • Dora Reglodi,
  • Péter Török,
  • Brigitta Orlik,
  • Antonio Simone Laganà,
  • Attila Jakab and
  • Tamas Juhasz

Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected women. Revealing alterations of the molecular processes in ectopic endometrial tissue is the current policy for understanding the pathomechanisms and di...

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Diagnostics - ISSN 2075-4418