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Diagnostics, Volume 12, Issue 4

April 2022 - 249 articles

Cover Story: Personalized diagnosis for thyroid nodules benefits from a combination of imagery and molecular biomarkers, as well as artificial intelligence algorithms, which are used more and more in our timeline. Functional imaging diagnosis such as SPECT, PET, or fused images (SPECT/CT, PET/CT, PET/MRI), is exploited at maximum in thyroid nodules, with a long history in the past and a bright future with many suitable radiotracers that could properly contribute to diagnosing malignancy in thyroid nodules. In this way, patients will be spared from surgery complications, and apparently more expensive diagnostic workouts will financially compensate each patient and also the healthcare system. For those in need of personalized therapeutic management, PRRT and gene therapies are in continuous development supporting thyroid carcinoma’s treatment gap. View this paper
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Articles (249)

  • Review
  • Open Access
17 Citations
3,943 Views
17 Pages

Sodium-Glucose Cotransporter-2 Inhibitors Improve Heart Failure with Reduced Ejection Fraction Outcomes by Reducing Edema and Congestion

  • Michelle Hernandez,
  • Ryan D. Sullivan,
  • Mariana E. McCune,
  • Guy L. Reed and
  • Inna P. Gladysheva

Pathological sodium-water retention or edema/congestion is a primary cause of heart failure (HF) decompensation, clinical symptoms, hospitalization, reduced quality of life, and premature mortality. Sodium-glucose cotransporter-2 inhibitors (SGLT-2i)...

  • Review
  • Open Access
21 Citations
7,438 Views
35 Pages

Surgery in Advanced Ovary Cancer: Primary versus Interval Cytoreduction

  • Mackenzie Cummings,
  • Olivia Nicolais and
  • Mark Shahin

Primary debulking surgery (PDS) has remained the only treatment of ovarian cancer with survival advantage since its development in the 1970s. However, survival advantage is only observed in patients who are optimally resected. Neoadjuvant chemotherap...

  • Article
  • Open Access
14 Citations
3,911 Views
17 Pages

Detection of Chronic Blast-Related Mild Traumatic Brain Injury with Diffusion Tensor Imaging and Support Vector Machines

  • Deborah L. Harrington,
  • Po-Ya Hsu,
  • Rebecca J. Theilmann,
  • Annemarie Angeles-Quinto,
  • Ashley Robb-Swan,
  • Sharon Nichols,
  • Tao Song,
  • Lu Le,
  • Carl Rimmele and
  • Scott Matthews
  • + 8 authors

Blast-related mild traumatic brain injury (bmTBI) often leads to long-term sequalae, but diagnostic approaches are lacking due to insufficient knowledge about the predominant pathophysiology. This study aimed to build a diagnostic model for future ve...

  • Article
  • Open Access
10 Citations
2,818 Views
11 Pages

Detection of Incomplete Irreversible Electroporation (IRE) and Microwave Ablation (MWA) of Hepatocellular Carcinoma (HCC) Using Iodine Quantification in Dual Energy Computed Tomography (DECT)

  • Wolf Bäumler,
  • Lukas Philipp Beyer,
  • Lukas Lürken,
  • Philipp Wiggermann,
  • Christian Stroszczynski,
  • Marco Dollinger and
  • Andreas Schicho

Early detection of local tumor progression (LTP) after irreversible electroporation (IRE) and microwave ablation (MWA) of hepatocellular carcinoma (HCC) remains challenging. The goal of this study was to identify cases with insufficient ablation and...

  • Article
  • Open Access
3 Citations
3,353 Views
10 Pages

Pathological Evaluation of Rectal Cancer Specimens Using Micro-Computed Tomography

  • Masao Yoshida,
  • Emine Cesmecioglu,
  • Canan Firat,
  • Hirotsugu Sakamoto,
  • Alexei Teplov,
  • Noboru Kawata,
  • Peter Ntiamoah,
  • Takashi Ohnishi,
  • Kareem Ibrahim and
  • Efsevia Vakiani
  • + 4 authors

Whole-block imaging (WBI) using micro-computed tomography (micro-CT) allows the nondestructive reconstruction of a three-dimensional view of tissues, implying that WBI may be used for accurate pathological evaluation of patients with rectal cancer. H...

  • Interesting Images
  • Open Access
2,470 Views
2 Pages

Monochorionic Diamniotic Twins with Bordering Cord Insertions: Images and Outcome

  • Lucian G. Pop,
  • Madalina Piron,
  • Viorica Radoi,
  • Nicolae Bacalbasa and
  • Oana D. Toader

Twin pregnancy contributes to perinatal mortality, particularly monochorionic diamniotic twin pregnancy. Placental abnormalities are much more common in twin pregnancies than in singletons. In MCDA pregnancy, vascular anastomoses are always present a...

  • Article
  • Open Access
12 Citations
3,369 Views
10 Pages

Background: Indocyanine green (ICG) lymphography is a newer technique for diagnosing lymphedema. Our study aimed to find whether the abnormality of ICG lymphography can predict the occurrence of early lymphedema and then select candidates at high ris...

  • Review
  • Open Access
20 Citations
6,601 Views
16 Pages

Speckle tracking echocardiography has emerged as a sensitive tool to analyze myocardial function with improved diagnostic accuracy and prognostic value. Left atrial strain assessment has become a novel imaging method in cardiology with superior progn...

  • Article
  • Open Access
5 Citations
2,817 Views
13 Pages

This study aims to evaluate significant gene expression in severe hypoxic ischemic encephalopathy (HIE) in newborns, which can be used as a predictable measure for high-risk HIE infants. The study prospectively recruited 77 inborn near-term or term H...

  • Article
  • Open Access
2,338 Views
11 Pages

Aortic Root Downward Movement as a Novel Method for Identification of an Adequately Performed Valsalva Maneuver to Detect Patent Foramen Ovale during Transesophageal Echocardiography

  • Lixin Chen,
  • Yuanyuan Sheng,
  • Yuxiang Huang,
  • Jian Li,
  • Xiaohua Liu,
  • Qian Liu,
  • Bobo Shi,
  • Xiaofang Zhong,
  • Jinfeng Xu and
  • Yingying Liu

The Valsalva maneuver (VM) is the most sensitive auxiliary method for the detection of patent foramen ovale (PFO), but it is difficult to assess whether the maneuver is adequately performed during transesophageal echocardiography (TEE). In this study...

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Diagnostics - ISSN 2075-4418