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Diagnostics, Volume 12, Issue 4

2022 April - 249 articles

Cover Story: Personalized diagnosis for thyroid nodules benefits from a combination of imagery and molecular biomarkers, as well as artificial intelligence algorithms, which are used more and more in our timeline. Functional imaging diagnosis such as SPECT, PET, or fused images (SPECT/CT, PET/CT, PET/MRI), is exploited at maximum in thyroid nodules, with a long history in the past and a bright future with many suitable radiotracers that could properly contribute to diagnosing malignancy in thyroid nodules. In this way, patients will be spared from surgery complications, and apparently more expensive diagnostic workouts will financially compensate each patient and also the healthcare system. For those in need of personalized therapeutic management, PRRT and gene therapies are in continuous development supporting thyroid carcinoma’s treatment gap. View this paper
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Articles (249)

  • Case Report
  • Open Access
4 Citations
4,419 Views
7 Pages

Clear cell odontogenic carcinoma (CCOC) is a rare, aggressive epithelial neoplasm of the jaw first described in 1985 by Hansen and classified as an odontogenic malignant tumor in the 2005 WHO classification. To date, only 117 cases have been reported...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
123 Citations
6,425 Views
12 Pages

Glioma Tumors’ Classification Using Deep-Neural-Network-Based Features with SVM Classifier

  • Ghazanfar Latif,
  • Ghassen Ben Brahim,
  • D. N. F. Awang Iskandar,
  • Abul Bashar and
  • Jaafar Alghazo

The complexity of brain tissue requires skillful technicians and expert medical doctors to manually analyze and diagnose Glioma brain tumors using multiple Magnetic Resonance (MR) images with multiple modalities. Unfortunately, manual diagnosis suffe...

(This article belongs to the Special Issue AI as a Tool to Improve Hybrid Imaging in Cancer)
  • Article
  • Open Access
12 Citations
4,672 Views
19 Pages

Novel User-Friendly Application for MRI Segmentation of Brain Resection following Epilepsy Surgery

  • Roberto Billardello,
  • Georgios Ntolkeras,
  • Assia Chericoni,
  • Joseph R. Madsen,
  • Christos Papadelis,
  • Phillip L. Pearl,
  • Patricia Ellen Grant,
  • Fabrizio Taffoni and
  • Eleonora Tamilia

Delineation of resected brain cavities on magnetic resonance images (MRIs) of epilepsy surgery patients is essential for neuroimaging/neurophysiology studies investigating biomarkers of the epileptogenic zone. The gold standard to delineate the resec...

(This article belongs to the Special Issue Brain Imaging in Epilepsy)
  • Review
  • Open Access
25 Citations
16,475 Views
17 Pages

Diagnosis and Management of Malignant Pleural Effusion: A Decade in Review

  • Blake Jacobs,
  • Ghias Sheikh,
  • Houssein A. Youness,
  • Jean I. Keddissi and
  • Tony Abdo

Malignant pleural effusion (MPE) is a common complication of thoracic and extrathoracic malignancies and is associated with high mortality. Treatment is mainly palliative, with symptomatic management achieved via effusion drainage and pleurodesis. Pl...

(This article belongs to the Special Issue Advances in Interventional Pulmonology)
  • Article
  • Open Access
7 Citations
3,351 Views
10 Pages

Prevalence of Occult Hepatitis C Virus Infection in Egyptian Patients with Lymphoma: A New Vision

  • Kholoud A. Elkashef,
  • Wafaa A. Emam,
  • Noha M. Mesbah,
  • Dina M. Abo-Elmatty and
  • Asmaa R. Abdel-Hamed

Occult hepatitis C virus infection (OCI) is the absence of HCV RNA in serum and the presence of actively replicating HCV RNA in hepatocytes and peripheral blood mononuclear cells (PBMCs), as evidenced by the presence of antigenomic negative sense sin...

(This article belongs to the Special Issue Diagnosis and Management of Hepatitis C)
  • Article
  • Open Access
2 Citations
2,562 Views
9 Pages

Semiautomated Segmentation and Volume Measurements of Cervical Carotid High-Signal Plaques Using 3D Turbo Spin-Echo T1-Weighted Black-Blood Vessel Wall Imaging: A Preliminary Study

  • Katsuhiro Inoue,
  • Ryohei Nakayama,
  • Shiho Isoshima,
  • Shinichi Takase,
  • Tsunehiro Yamahata,
  • Maki Umino,
  • Masayuki Maeda and
  • Hajime Sakuma

Unstable carotid plaques are visualized as high-signal plaques (HSPs) on 3D turbo spin-echo T1-weighted black-blood vessel wall imaging (3D TSE T1-BB VWI). The purpose of this study was to compare manual segmentation and semiautomated segmentation fo...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
4 Citations
3,042 Views
9 Pages

Faecal Immunochemical Test Impact on Prognosis of Colorectal Cancer Detected in Symptomatic Patients

  • Jesús Daniel Fernández de Castro,
  • Franco Baiocchi Ureta,
  • Raquel Fernández González,
  • Noel Pin Vieito and
  • Joaquín Cubiella Fernández

The use of the faecal immunochemical test (FIT) to stratify the risk of colorectal cancer (CRC) in symptomatic patients in primary healthcare enables improved referrals to colonoscopy. However, its effect on diagnostic delays or the prognosis of pati...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
43 Citations
6,225 Views
12 Pages

Splenic Artery Pseudoaneurysms: The Role of ce-CT for Diagnosis and Treatment Planning

  • Fabio Corvino,
  • Francesco Giurazza,
  • Anna Maria Ierardi,
  • Pierleone Lucatelli,
  • Antonello Basile,
  • Antonio Corvino and
  • Raffaella Niola

Splenic artery pseudoaneurysm (PSA) is a contained vascular wall lesion associated with a high mortality rate, generally related to pancreatitis, trauma, malignancy, iatrogenic injury, and segmental arterial mediolysis. Computed tomography angiograph...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Systematic Review
  • Open Access
25 Citations
5,342 Views
11 Pages

Utility of Red Cell Distribution Width (RDW) as a Noninvasive Biomarker for the Diagnosis of Acute Appendicitis: A Systematic Review and Meta-Analysis of 5222 Cases

  • Sachit Anand,
  • Nellai Krishnan,
  • Miro Jukić,
  • Zvonimir Križanac,
  • Carlos Martin Llorente Muñoz and
  • Zenon Pogorelić

Background: Despite great advances in medicine, numerous available laboratory markers, and radiological imaging, the diagnosis of acute appendicitis (AA) in some cases still remains controversial and challenging for clinicians. Because of that, clini...

(This article belongs to the Special Issue Advances in the Diagnosis of Gastrointestinal Diseases)
  • Article
  • Open Access
9 Citations
4,797 Views
12 Pages

Assessment of Maxillary Molars Interradicular Septum Morphological Characteristics as Criteria for Ideal Immediate Implant Placement—The Advantages of Cone Beam Computed Tomography Analysis

  • Zlata Rajkovic Pavlovic,
  • Pavle Milanovic,
  • Milica Vasiljevic,
  • Nemanja Jovicic,
  • Aleksandra Arnaut,
  • Djurdjina Colic,
  • Marijana Petrovic,
  • Momir Stevanovic,
  • Dragica Selakovic and
  • Gvozden Rosic

The aim of this study was to evaluate the interradicular septum bone morphometric characteristics using cone beam computed tomography (CBCT) images, as well as to establish quantitative shortcuts to allow clinicians to make a faster and more reliable...

(This article belongs to the Special Issue Advances in Diagnostic Medical Imaging)
  • Article
  • Open Access
15 Citations
3,078 Views
11 Pages

Use of a Feed-Forward Back Propagation Network for the Prediction of Small for Gestational Age Newborns in a Cohort of Pregnant Patients with Thrombophilia

  • Petronela Vicoveanu,
  • Ingrid Andrada Vasilache,
  • Ioana Sadiye Scripcariu,
  • Dragos Nemescu,
  • Alexandru Carauleanu,
  • Dragos Vicoveanu,
  • Ana Roxana Covali,
  • Catalina Filip and
  • Demetra Socolov

(1) Background: Fetal growth restriction is a relatively common disorder in pregnant patients with thrombophilia. New artificial intelligence algorithms are a promising option for the prediction of adverse obstetrical outcomes. The aim of this study...

(This article belongs to the Special Issue Artificial Intelligence in Clinical Medical Imaging Analysis)
  • Article
  • Open Access
17 Citations
5,895 Views
17 Pages

Multicentric Evaluation of SeeGene Allplex Real-Time PCR Assays Targeting 28 Bacterial, Microsporidal and Parasitic Nucleic Acid Sequences in Human Stool Samples

  • Felix Weinreich,
  • Andreas Hahn,
  • Kirsten Alexandra Eberhardt,
  • Simone Kann,
  • Thomas Köller,
  • Philipp Warnke,
  • Susann Dupke,
  • Denise Dekker,
  • Jürgen May and
  • Ulrike Loderstädt
  • + 1 author

Prior to the implementation of new diagnostic techniques, a thorough evaluation is mandatory in order to ensure diagnostic reliability. If positive samples are scarcely available, however, such evaluations can be difficult to perform. Here, we evalua...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
9 Citations
6,855 Views
14 Pages

Urine Flow Cytometry Parameter Cannot Safely Predict Contamination of Urine—A Cohort Study of a Swiss Emergency Department Using Machine Learning Techniques

  • Martin Müller,
  • Nadine Sägesser,
  • Peter M. Keller,
  • Spyridon Arampatzis,
  • Benedict Steffens,
  • Simone Ehrhard and
  • Alexander B. Leichtle

Background: Urine flow cytometry (UFC) analyses urine samples and determines parameter counts. We aimed to predict different types of urine culture growth, including mixed growth indicating urine culture contamination. Methods: A retrospective cohort...

(This article belongs to the Special Issue Urinary Stones and Infections)
  • Review
  • Open Access
55 Citations
44,550 Views
15 Pages

Imaging of the Temporomandibular Joint

  • Seyed Mohammad Gharavi,
  • Yujie Qiao,
  • Armaghan Faghihimehr and
  • Josephina Vossen

Temporomandibular disorder (TMD) is a common musculoskeletal condition that causes pain and disability for patients and imposes a high financial burden on the healthcare system. The most common cause of TMD is internal derangement, mainly secondary t...

(This article belongs to the Special Issue Skeletal Radiology)
  • Review
  • Open Access
10 Citations
8,256 Views
11 Pages

Surgical Treatment in Silicone Oil-Associated Glaucoma

  • Catalin Cornacel,
  • Otilia-Maria Dumitrescu,
  • Alexandra Catalina Zaharia,
  • Ruxandra Angela Pirvulescu,
  • Mihnea Munteanu,
  • Calin Petru Tataru and
  • Sinziana Istrate

Glaucoma is a vision threatening, not uncommon complication of eyes that have undergone pars plana vitrectomy with silicone oil endotamponade. Although most patients respond well to medical antiglaucoma therapy, there are refractory cases where surge...

(This article belongs to the Special Issue Diagnosis and Management of Glaucoma)
  • Article
  • Open Access
7 Citations
3,321 Views
9 Pages

Diagnosing pancreatic malignancy is challenging, especially in patients with chronic pancreatitis (CP). Endoscopic ultrasonography (EUS) is a promising diagnostic procedure for discriminating between malignancy and CP. We aimed to investigate the pre...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Case Report
  • Open Access
2 Citations
3,564 Views
9 Pages

Total Pancreatectomy for Multicentric Cystic Neuroendocrine Tumor of the Pancreas: A Case Report

  • Milica Mitrovic-Jovanovic,
  • Nikica Grubor,
  • Stefan Milosevic,
  • Aleksandra Jankovic,
  • Katarina Stosic,
  • Slavenko Ostojic,
  • Aleksandar Ninic,
  • Marjan Micev and
  • Jelena Djokic Kovac

Pancreatic neuroendocrine tumors (PNETs) are uncommon pancreatic neoplasms with malignant potential, heterogeneous clinical behavior, as well as imaging appearance. These tumors represent less than 3% of all pancreatic neoplasms with typical CT prese...

(This article belongs to the Special Issue Advances in the Diagnosis of Gastrointestinal Diseases)
  • Article
  • Open Access
21 Citations
4,359 Views
13 Pages

Radiomics for the Prediction of Response to Antifibrotic Treatment in Patients with Idiopathic Pulmonary Fibrosis: A Pilot Study

  • Cheng-Chun Yang,
  • Chin-Yu Chen,
  • Yu-Ting Kuo,
  • Ching-Chung Ko,
  • Wen-Jui Wu,
  • Chia-Hao Liang,
  • Chun-Ho Yun and
  • Wei-Ming Huang

Antifibrotic therapy has changed the treatment paradigm for idiopathic pulmonary fibrosis (IPF); however, a subset of patients still experienced rapid disease progression despite treatment. This study aimed to determine whether CT-based radiomic feat...

(This article belongs to the Special Issue Artificial Intelligence in Lung Diseases 2.0)
  • Article
  • Open Access
3 Citations
3,309 Views
11 Pages

Parkinson’s Disease Symptoms Associated with Developing On-State Axial Symptoms Early after Subthalamic Deep Brain Stimulation

  • Gustavo Fernández-Pajarín,
  • Ángel Sesar,
  • José Luis Relova,
  • Begoña Ares,
  • Isabel Jiménez,
  • Miguel Gelabert-González,
  • Eduardo Arán and
  • Alfonso Castro

Background: The relationship between axial symptoms in Parkinson’s disease (PD) and subthalamic deep brain stimulation (STN-DBS) is still unclear. Purpose: We searched for particular clinical characteristics before STN-DBS linked to on-state ax...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Case Report
  • Open Access
2 Citations
3,455 Views
5 Pages

To date, along with the progress of new technology and computer program development, the high-resolution computed tomography (HRCT) had been applied in different clinical application, such as HRCT for coronary angiography. In the current neuroimaging...

(This article belongs to the Special Issue Head and Neck Imaging)
  • Article
  • Open Access
5 Citations
2,859 Views
17 Pages

Decision Support for Oropharyngeal Cancer Patients Based on Data-Driven Similarity Metrics for Medical Case Comparison

  • Julia Buyer,
  • Alexander Oeser,
  • Nora Grieb,
  • Andreas Dietz,
  • Thomas Neumuth and
  • Matthaeus Stoehr

Making complex medical decisions is becoming an increasingly challenging task due to the growing amount of available evidence to consider and the higher demand for personalized treatment and patient care. IT systems for the provision of clinical deci...

(This article belongs to the Special Issue Advances in Diagnostics of Head and Neck Cancer)
  • Case Report
  • Open Access
5 Citations
4,052 Views
6 Pages

Background: POEMS syndrome (POEMS) is a rare plasma cell clonal paraneoplastic syndrome consisting of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes presenting with idiopathic multicentric Castleman disease (iMCD)...

(This article belongs to the Topic Diagnostic Imaging and Pathology in Cancer Research)
  • Article
  • Open Access
20 Citations
3,828 Views
11 Pages

Background: To develop and validate a radiomics model based on 18F-FDG PET/CT images to preoperatively predict occult axillary lymph node (ALN) metastases in patients with invasive ductal breast cancer (IDC) with clinically node-negative (cN0); Metho...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
3 Citations
3,596 Views
11 Pages

Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia

  • Immacolata Redavid,
  • Maria Rosa Conserva,
  • Luisa Anelli,
  • Antonella Zagaria,
  • Giorgina Specchia,
  • Pellegrino Musto and
  • Francesco Albano

Acute myeloid leukemia (AML) is a haematological neoplasm resulting from the accumulation of genetic and epigenetic alterations. Patients’ prognoses vary with AML genetic heterogeneity, which hampers successful treatments. Single-cell approache...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
139 Citations
9,473 Views
16 Pages

Electroencephalography-based motor imagery (EEG-MI) classification is a critical component of the brain-computer interface (BCI), which enables people with physical limitations to communicate with the outside world via assistive technology. Regrettab...

(This article belongs to the Special Issue Intelligent Data Analysis for Medical Diagnosis)
  • Communication
  • Open Access
10 Citations
3,587 Views
10 Pages

Programming Optimization in Implantable Cardiac Monitors to Reduce False-Positive Arrhythmia Alerts: A Call for Research

  • Fabrizio Guarracini,
  • Martina Testolina,
  • Daniele Giacopelli,
  • Marta Martin,
  • Francesco Triglione,
  • Alessio Coser,
  • Silvia Quintarelli,
  • Roberto Bonmassari and
  • Massimiliano Marini

No studies have investigated whether optimizing implantable cardiac monitors (ICM) programming can reduce false-positive (FP) alerts. We identified patients implanted with an ICM (BIOMONITOR III) who had more than 10 FP alerts in a 1-month retrospect...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
20 Citations
4,070 Views
9 Pages

Analysis of Septin 9 Gene Hypermethylation as Follow-Up Biomarker of Colorectal Cancer Patients after Curative Surgery

  • Miguel Leon Arellano,
  • Mariano García-Arranz,
  • Héctor Guadalajara,
  • Rocío Olivera-Salazar,
  • Teresa Valdes-Sanchez and
  • Damián García-Olmo

Background: The Septin 9 test analyzes the methylation status of the SEPT9 gene, which appears to be hypermethylated in patients with colorectal cancer (CRC). This has been validated as a colorectal cancer screening test. Due to the high sensitivity...

(This article belongs to the Special Issue Cell-Free Nucleic Acids—New Insights into Physico-Chemical Properties, Analytical Considerations, and Clinical Applications)
  • Article
  • Open Access
5 Citations
4,135 Views
11 Pages

Doppler and Spectral Ultrasound of Sacroiliac Joints in Pediatric Patients with Suspected Juvenile Spondyloarthritis

  • Paolo Falsetti,
  • Edoardo Conticini,
  • Carla Gaggiano,
  • Caterina Baldi,
  • Maria Tarsia,
  • Marco Bardelli,
  • Stefano Gentileschi,
  • Roberto D’Alessandro,
  • Suhel Gabriele Al Khayyat and
  • Bruno Frediani
  • + 4 authors

Background: Power Doppler ultrasound (PDUS) with spectral wave analysis (SWA) has been compared with magnetic resonance imaging (MRI) in documenting active sacroiliitis in early spondyloarthritis (SpA) but, to date, PDUS/SWA has not been yet applied...

(This article belongs to the Special Issue Ultrasound Imaging in Medicine 2022)
  • Article
  • Open Access
29 Citations
4,222 Views
18 Pages

Background: The presence of heavy calcification in the coronary artery always presents a challenge for coronary computed tomography angiography (CCTA) in assessing the degree of coronary stenosis due to blooming artifacts associated with calcified pl...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
33 Citations
5,513 Views
16 Pages

Fast Segmentation of Metastatic Foci in H&E Whole-Slide Images for Breast Cancer Diagnosis

  • Muhammad-Adil Khalil,
  • Yu-Ching Lee,
  • Huang-Chun Lien,
  • Yung-Ming Jeng and
  • Ching-Wei Wang

Breast cancer is the leading cause of death for women globally. In clinical practice, pathologists visually scan over enormous amounts of gigapixel microscopic tissue slide images, which is a tedious and challenging task. In breast cancer diagnosis,...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
22 Citations
4,619 Views
17 Pages

Sodium-Glucose Cotransporter-2 Inhibitors Improve Heart Failure with Reduced Ejection Fraction Outcomes by Reducing Edema and Congestion

  • Michelle Hernandez,
  • Ryan D. Sullivan,
  • Mariana E. McCune,
  • Guy L. Reed and
  • Inna P. Gladysheva

Pathological sodium-water retention or edema/congestion is a primary cause of heart failure (HF) decompensation, clinical symptoms, hospitalization, reduced quality of life, and premature mortality. Sodium-glucose cotransporter-2 inhibitors (SGLT-2i)...

(This article belongs to the Special Issue Diagnosis and Management of Heart Failure)
  • Review
  • Open Access
32 Citations
10,205 Views
35 Pages

Surgery in Advanced Ovary Cancer: Primary versus Interval Cytoreduction

  • Mackenzie Cummings,
  • Olivia Nicolais and
  • Mark Shahin

Primary debulking surgery (PDS) has remained the only treatment of ovarian cancer with survival advantage since its development in the 1970s. However, survival advantage is only observed in patients who are optimally resected. Neoadjuvant chemotherap...

(This article belongs to the Special Issue Ovarian Cancer 3.0: Characteristics, Screening, Diagnosis and Treatment)
  • Article
  • Open Access
16 Citations
4,560 Views
17 Pages

Detection of Chronic Blast-Related Mild Traumatic Brain Injury with Diffusion Tensor Imaging and Support Vector Machines

  • Deborah L. Harrington,
  • Po-Ya Hsu,
  • Rebecca J. Theilmann,
  • Annemarie Angeles-Quinto,
  • Ashley Robb-Swan,
  • Sharon Nichols,
  • Tao Song,
  • Lu Le,
  • Carl Rimmele and
  • Mingxiong Huang
  • + 8 authors

Blast-related mild traumatic brain injury (bmTBI) often leads to long-term sequalae, but diagnostic approaches are lacking due to insufficient knowledge about the predominant pathophysiology. This study aimed to build a diagnostic model for future ve...

(This article belongs to the Topic Medical Image Analysis)
  • Article
  • Open Access
11 Citations
3,289 Views
11 Pages

Detection of Incomplete Irreversible Electroporation (IRE) and Microwave Ablation (MWA) of Hepatocellular Carcinoma (HCC) Using Iodine Quantification in Dual Energy Computed Tomography (DECT)

  • Wolf Bäumler,
  • Lukas Philipp Beyer,
  • Lukas Lürken,
  • Philipp Wiggermann,
  • Christian Stroszczynski,
  • Marco Dollinger and
  • Andreas Schicho

Early detection of local tumor progression (LTP) after irreversible electroporation (IRE) and microwave ablation (MWA) of hepatocellular carcinoma (HCC) remains challenging. The goal of this study was to identify cases with insufficient ablation and...

(This article belongs to the Special Issue Recent Advances in Liver Diseases Diagnosis)
  • Article
  • Open Access
4 Citations
4,155 Views
10 Pages

Pathological Evaluation of Rectal Cancer Specimens Using Micro-Computed Tomography

  • Masao Yoshida,
  • Emine Cesmecioglu,
  • Canan Firat,
  • Hirotsugu Sakamoto,
  • Alexei Teplov,
  • Noboru Kawata,
  • Peter Ntiamoah,
  • Takashi Ohnishi,
  • Kareem Ibrahim and
  • Yukako Yagi
  • + 4 authors

Whole-block imaging (WBI) using micro-computed tomography (micro-CT) allows the nondestructive reconstruction of a three-dimensional view of tissues, implying that WBI may be used for accurate pathological evaluation of patients with rectal cancer. H...

(This article belongs to the Collection Advances in Cancer Imaging)
  • Interesting Images
  • Open Access
2,918 Views
2 Pages

Monochorionic Diamniotic Twins with Bordering Cord Insertions: Images and Outcome

  • Lucian G. Pop,
  • Madalina Piron,
  • Viorica Radoi,
  • Nicolae Bacalbasa and
  • Oana D. Toader

Twin pregnancy contributes to perinatal mortality, particularly monochorionic diamniotic twin pregnancy. Placental abnormalities are much more common in twin pregnancies than in singletons. In MCDA pregnancy, vascular anastomoses are always present a...

(This article belongs to the Special Issue Imaging of Fetal and Maternal Diseases in Pregnancy)
  • Article
  • Open Access
19 Citations
3,969 Views
10 Pages

Background: Indocyanine green (ICG) lymphography is a newer technique for diagnosing lymphedema. Our study aimed to find whether the abnormality of ICG lymphography can predict the occurrence of early lymphedema and then select candidates at high ris...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
23 Citations
7,565 Views
16 Pages

Speckle tracking echocardiography has emerged as a sensitive tool to analyze myocardial function with improved diagnostic accuracy and prognostic value. Left atrial strain assessment has become a novel imaging method in cardiology with superior progn...

(This article belongs to the Special Issue Echocardiography)
  • Article
  • Open Access
7 Citations
3,321 Views
13 Pages

This study aims to evaluate significant gene expression in severe hypoxic ischemic encephalopathy (HIE) in newborns, which can be used as a predictable measure for high-risk HIE infants. The study prospectively recruited 77 inborn near-term or term H...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
1 Citations
2,737 Views
11 Pages

Aortic Root Downward Movement as a Novel Method for Identification of an Adequately Performed Valsalva Maneuver to Detect Patent Foramen Ovale during Transesophageal Echocardiography

  • Lixin Chen,
  • Yuanyuan Sheng,
  • Yuxiang Huang,
  • Jian Li,
  • Xiaohua Liu,
  • Qian Liu,
  • Bobo Shi,
  • Xiaofang Zhong,
  • Jinfeng Xu and
  • Yingying Liu

The Valsalva maneuver (VM) is the most sensitive auxiliary method for the detection of patent foramen ovale (PFO), but it is difficult to assess whether the maneuver is adequately performed during transesophageal echocardiography (TEE). In this study...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
4 Citations
3,085 Views
11 Pages

Association between the Concentrations of Essential and Toxic Elements in Mid-Trimester Amniotic Fluid and Fetal Chromosomal Abnormalities in Pregnant Polish Women

  • Joanna Suliburska,
  • Jakub Pankiewicz,
  • Adam Sajnóg,
  • Magdalena Paczkowska,
  • Beata Nowakowska,
  • Ewa Bakinowska,
  • Danuta Barałkiewicz and
  • Rafał Kocyłowski

The present study aimed to investigate the relationship between the concentrations of essential and toxic elements present in the amniotic fluid (AF) and fetal chromosomal abnormalities in pregnant women. A total of 156 pregnant white Polish women ag...

(This article belongs to the Special Issue Diagnosis and Management in Prenatal Medicine)
  • Review
  • Open Access
103 Citations
16,529 Views
12 Pages

Cell-Free DNA Fragmentomics in Liquid Biopsy

  • Spencer C. Ding and
  • Y.M. Dennis Lo

Cell-free DNA (cfDNA) in bodily fluids has rapidly transformed the development of noninvasive prenatal testing, cancer liquid biopsy, and transplantation monitoring. Plasma cfDNA consists of a mixture of molecules originating from various bodily tiss...

(This article belongs to the Special Issue Cell-Free Nucleic Acids—New Insights into Physico-Chemical Properties, Analytical Considerations, and Clinical Applications)
  • Review
  • Open Access
48 Citations
9,718 Views
14 Pages

Pituitary adenomas (PAs) are benign lesions; nonetheless, some PAs exhibit aggressive behaviors, which lead to recurrence. The impact of pituitary dysfunction, invasion-related risks, and other complications considerably affect the quality of life of...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
2,907 Views
9 Pages

Predictive Variables for Interventional Angiography among Patients with Knee Hemarthrosis

  • Sang-Hun Ko,
  • Kwang-Hwan Jung,
  • Jae-Ryong Cha and
  • Ki-Bong Park

Studies regarding the variables that could predict the success of conservative treatment for knee hemarthrosis are lacking. This retrospective study evaluated the laboratory variables of patients who had unsatisfactory results from conservative treat...

(This article belongs to the Special Issue Management of Knee Problems Based on the Proper Diagnostic Procedures)
  • Article
  • Open Access
37 Citations
4,950 Views
13 Pages

Development of an Interactive AI System for the Optimal Timing Prediction of Successful Weaning from Mechanical Ventilation for Patients in Respiratory Care Centers

  • Kuang-Ming Liao,
  • Shian-Chin Ko,
  • Chung-Feng Liu,
  • Kuo-Chen Cheng,
  • Chin-Ming Chen,
  • Mei-I Sung,
  • Shu-Chen Hsing and
  • Chia-Jung Chen

Successful weaning from prolonged mechanical ventilation (MV) is an important issue in respiratory care centers (RCCs). Delayed or premature extubation increases both the risk of adverse outcomes and healthcare costs. However, the accurate evaluation...

(This article belongs to the Special Issue Artificial Intelligence in Lung Diseases 2.0)
  • Article
  • Open Access
14 Citations
4,178 Views
9 Pages

Unusual N Gene Dropout and Ct Value Shift in Commercial Multiplex PCR Assays Caused by Mutated SARS-CoV-2 Strain

  • Petros Bozidis,
  • Eleni T. Tsaousi,
  • Charilaos Kostoulas,
  • Prodromos Sakaloglou,
  • Athanasia Gouni,
  • Despoina Koumpouli,
  • Hercules Sakkas,
  • Ioannis Georgiou and
  • Konstantina Gartzonika

Several SARS-CoV-2 variants have emerged and early detection for monitoring their prevalence is crucial. Many identification strategies have been implemented in cases where sequencing data for confirmation is pending or not available. The presence of...

(This article belongs to the Collection Diagnostic Virology)
  • Brief Report
  • Open Access
5 Citations
2,813 Views
7 Pages

Placental Ultrasonographical Findings during SARS-CoV-2 Infection

  • Sotirios Sotiriou,
  • Athina A. Samara,
  • Iokasti-Apostolia Tsiamalou,
  • Christos Donoudis,
  • Eleni Seviloglou,
  • Chara Skentou,
  • Antonios Garas and
  • Alexandros Daponte

Infection with SARS-CoV-2 virus (COVID-19) during pregnancy has been associated with several complications. Increasing evidence suggests that COVID-19 infection leaves tell-tale signs of placental injury. During ultrasound examination and placental e...

(This article belongs to the Topic Fighting against COVID-19: Latest Advances, Challenges and Methodologies)
  • Article
  • Open Access
14 Citations
4,097 Views
16 Pages

Smartphone-Enabled versus Conventional Otoscopy in Detecting Middle Ear Disease: A Meta-Analysis

  • Chih-Hao Chen,
  • Chii-Yuan Huang,
  • Hsiu-Lien Cheng,
  • Heng-Yu Haley Lin,
  • Yuan-Chia Chu,
  • Chun-Yu Chang,
  • Ying-Hui Lai,
  • Mao-Che Wang and
  • Yen-Fu Cheng

Traditional otoscopy has some limitations, including poor visualization and inadequate time for evaluation in suboptimal environments. Smartphone-enabled otoscopy may improve examination quality and serve as a potential diagnostic tool for middle ear...

(This article belongs to the Special Issue Advances in Diagnostics of Otology and Neurotology)
  • Article
  • Open Access
13 Citations
5,401 Views
18 Pages

COVID-19 in Tunisia (North Africa): Seroprevalence of SARS-CoV-2 in the General Population of the Capital City Tunis

  • Ines Cherif,
  • Ghassen Kharroubi,
  • Sana Chaabane,
  • Rihab Yazidi,
  • Mongi Dellagi,
  • Mohamed Ali Snoussi,
  • Sadok Salem,
  • Soumaya Marzouki,
  • Wafa Kammoun Rebai and
  • Jihene Bettaieb
  • + 5 authors

Seroprevalence studies are essential to get an accurate estimate of the actual SARS-CoV-2 diffusion within populations. We report on the findings of the first serosurvey conducted in Tunis prior to the implementation of mass vaccination and analyzed...

(This article belongs to the Special Issue Multidisciplinary Approaches to Manage COVID-19: From Surveillance to Diagnosis)
  • Article
  • Open Access
8 Citations
4,076 Views
15 Pages

Endometrium as Control of Endometriosis in Experimental Research: Assessment of Sample Suitability

  • Vince Szegeczki,
  • László Fazekas,
  • Máté Kulcsár,
  • Dora Reglodi,
  • Péter Török,
  • Brigitta Orlik,
  • Antonio Simone Laganà,
  • Attila Jakab and
  • Tamas Juhasz

Endometriosis is a chronic gynecological disease that causes numerous severe symptoms in affected women. Revealing alterations of the molecular processes in ectopic endometrial tissue is the current policy for understanding the pathomechanisms and di...

(This article belongs to the Special Issue Advances in the Diagnostics of Endometriosis)

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Diagnostics - ISSN 2075-4418