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Diagnostics, Volume 12, Issue 4

April 2022 - 249 articles

Cover Story: Personalized diagnosis for thyroid nodules benefits from a combination of imagery and molecular biomarkers, as well as artificial intelligence algorithms, which are used more and more in our timeline. Functional imaging diagnosis such as SPECT, PET, or fused images (SPECT/CT, PET/CT, PET/MRI), is exploited at maximum in thyroid nodules, with a long history in the past and a bright future with many suitable radiotracers that could properly contribute to diagnosing malignancy in thyroid nodules. In this way, patients will be spared from surgery complications, and apparently more expensive diagnostic workouts will financially compensate each patient and also the healthcare system. For those in need of personalized therapeutic management, PRRT and gene therapies are in continuous development supporting thyroid carcinoma’s treatment gap. View this paper
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Articles (249)

  • Article
  • Open Access
4 Citations
2,490 Views
17 Pages

Decision Support for Oropharyngeal Cancer Patients Based on Data-Driven Similarity Metrics for Medical Case Comparison

  • Julia Buyer,
  • Alexander Oeser,
  • Nora Grieb,
  • Andreas Dietz,
  • Thomas Neumuth and
  • Matthaeus Stoehr

Making complex medical decisions is becoming an increasingly challenging task due to the growing amount of available evidence to consider and the higher demand for personalized treatment and patient care. IT systems for the provision of clinical deci...

  • Case Report
  • Open Access
3 Citations
3,419 Views
6 Pages

Background: POEMS syndrome (POEMS) is a rare plasma cell clonal paraneoplastic syndrome consisting of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes presenting with idiopathic multicentric Castleman disease (iMCD)...

  • Article
  • Open Access
16 Citations
3,346 Views
11 Pages

Background: To develop and validate a radiomics model based on 18F-FDG PET/CT images to preoperatively predict occult axillary lymph node (ALN) metastases in patients with invasive ductal breast cancer (IDC) with clinically node-negative (cN0); Metho...

  • Review
  • Open Access
3 Citations
3,184 Views
11 Pages

Single-Cell Sequencing: Ariadne’s Thread in the Maze of Acute Myeloid Leukemia

  • Immacolata Redavid,
  • Maria Rosa Conserva,
  • Luisa Anelli,
  • Antonella Zagaria,
  • Giorgina Specchia,
  • Pellegrino Musto and
  • Francesco Albano

Acute myeloid leukemia (AML) is a haematological neoplasm resulting from the accumulation of genetic and epigenetic alterations. Patients’ prognoses vary with AML genetic heterogeneity, which hampers successful treatments. Single-cell approache...

  • Article
  • Open Access
96 Citations
8,003 Views
16 Pages

Electroencephalography-based motor imagery (EEG-MI) classification is a critical component of the brain-computer interface (BCI), which enables people with physical limitations to communicate with the outside world via assistive technology. Regrettab...

  • Communication
  • Open Access
8 Citations
3,196 Views
10 Pages

Programming Optimization in Implantable Cardiac Monitors to Reduce False-Positive Arrhythmia Alerts: A Call for Research

  • Fabrizio Guarracini,
  • Martina Testolina,
  • Daniele Giacopelli,
  • Marta Martin,
  • Francesco Triglione,
  • Alessio Coser,
  • Silvia Quintarelli,
  • Roberto Bonmassari and
  • Massimiliano Marini

No studies have investigated whether optimizing implantable cardiac monitors (ICM) programming can reduce false-positive (FP) alerts. We identified patients implanted with an ICM (BIOMONITOR III) who had more than 10 FP alerts in a 1-month retrospect...

  • Article
  • Open Access
11 Citations
3,319 Views
9 Pages

Analysis of Septin 9 Gene Hypermethylation as Follow-Up Biomarker of Colorectal Cancer Patients after Curative Surgery

  • Miguel Leon Arellano,
  • Mariano García-Arranz,
  • Héctor Guadalajara,
  • Rocío Olivera-Salazar,
  • Teresa Valdes-Sanchez and
  • Damián García-Olmo

Background: The Septin 9 test analyzes the methylation status of the SEPT9 gene, which appears to be hypermethylated in patients with colorectal cancer (CRC). This has been validated as a colorectal cancer screening test. Due to the high sensitivity...

  • Article
  • Open Access
4 Citations
3,525 Views
11 Pages

Doppler and Spectral Ultrasound of Sacroiliac Joints in Pediatric Patients with Suspected Juvenile Spondyloarthritis

  • Paolo Falsetti,
  • Edoardo Conticini,
  • Carla Gaggiano,
  • Caterina Baldi,
  • Maria Tarsia,
  • Marco Bardelli,
  • Stefano Gentileschi,
  • Roberto D’Alessandro,
  • Suhel Gabriele Al Khayyat and
  • Alessandra Cartocci
  • + 4 authors

Background: Power Doppler ultrasound (PDUS) with spectral wave analysis (SWA) has been compared with magnetic resonance imaging (MRI) in documenting active sacroiliitis in early spondyloarthritis (SpA) but, to date, PDUS/SWA has not been yet applied...

  • Article
  • Open Access
26 Citations
3,733 Views
18 Pages

Background: The presence of heavy calcification in the coronary artery always presents a challenge for coronary computed tomography angiography (CCTA) in assessing the degree of coronary stenosis due to blooming artifacts associated with calcified pl...

  • Article
  • Open Access
30 Citations
4,828 Views
16 Pages

Fast Segmentation of Metastatic Foci in H&E Whole-Slide Images for Breast Cancer Diagnosis

  • Muhammad-Adil Khalil,
  • Yu-Ching Lee,
  • Huang-Chun Lien,
  • Yung-Ming Jeng and
  • Ching-Wei Wang

Breast cancer is the leading cause of death for women globally. In clinical practice, pathologists visually scan over enormous amounts of gigapixel microscopic tissue slide images, which is a tedious and challenging task. In breast cancer diagnosis,...

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Diagnostics - ISSN 2075-4418