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Life, Volume 14, Issue 3

March 2024 - 142 articles

Cover Story: Immunotherapy has emerged as a promising strategy, harnessing the body’s immune system to combat gynecological cancer. This literature review provides a comprehensive overview of the current landscape and future directions of immunotherapy in cervical and endometrial cancer. It presents the most critical methods and treatments employed in immunotherapy for cervical and endometrial cancer, including immune checkpoint inhibitors, cancer vaccines, and adoptive cell therapies. Immune checkpoint inhibitors, such as anti-PD-1/PD-L1 antibodies, have shown remarkable clinical efficacy in certain gynecological malignancies, particularly in advanced or recurrent cases. Ongoing research on cancer vaccines and adoptive cell therapies holds promise for personalized and targeted treatment options. View this paper
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Articles (142)

  • Article
  • Open Access
2,872 Views
10 Pages

Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas

  • Mateusz K. Mateuszczyk,
  • Iwona Chlebicka,
  • Magdalena Łyko,
  • Joanna Maj and
  • Jacek C. Szepietowski

21 March 2024

Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seve...

  • Review
  • Open Access
20 Citations
6,166 Views
25 Pages

Antitumor Mechanisms of Lycium barbarum Fruit: An Overview of In Vitro and In Vivo Potential

  • Maria Rosaria Miranda,
  • Vincenzo Vestuto,
  • Giuseppina Amodio,
  • Michele Manfra,
  • Giacomo Pepe and
  • Pietro Campiglia

21 March 2024

Lycium barbarum, known as goji berry or wolfberry, is a fruit long associated with health benefits, showing a plethora of effects ranging from antioxidant, anticancer, anti-inflammatory, and immunomodulatory effects. Its potential is attributed to th...

  • Article
  • Open Access
10 Citations
3,176 Views
20 Pages

Generative-Adversarial-Network-Based Image Reconstruction for the Capacitively Coupled Electrical Impedance Tomography of Stroke

  • Mikhail Ivanenko,
  • Damian Wanta,
  • Waldemar T. Smolik,
  • Przemysław Wróblewski and
  • Mateusz Midura

21 March 2024

This study investigated the potential of machine-learning-based stroke image reconstruction in capacitively coupled electrical impedance tomography. The quality of brain images reconstructed using the adversarial neural network (cGAN) was examined. T...

  • Review
  • Open Access
33 Citations
9,306 Views
19 Pages

Chronic Kidney Disease with Mineral Bone Disorder and Vascular Calcification: An Overview

  • Carmine Izzo,
  • Carmine Secondulfo,
  • Giancarlo Bilancio,
  • Valeria Visco,
  • Nicola Virtuoso,
  • Serena Migliarino,
  • Michele Ciccarelli,
  • Paola Di Pietro,
  • Lucia La Mura and
  • Antonio Damato
  • + 2 authors

21 March 2024

Chronic kidney disease (CKD) is a global health issue with a rising prevalence, affecting 697.5 million people worldwide. It imposes a substantial burden, contributing to 35.8 million disability-adjusted life years (DALYs) and 1.2 million deaths in 2...

  • Review
  • Open Access
27 Citations
11,423 Views
22 Pages

Cell Immortality: In Vitro Effective Techniques to Achieve and Investigate Its Applications and Challenges

  • Mahla Chalak,
  • Mahdi Hesaraki,
  • Seyedeh Nasim Mirbahari,
  • Meghdad Yeganeh,
  • Shaghayegh Abdi,
  • Sarah Rajabi and
  • Farhid Hemmatzadeh

21 March 2024

Cells are very important to researchers due to their use in various biological studies in in vitro and in vivo settings. This importance stems from the short lifespan of most cells under laboratory conditions, which can pose significant challenges, s...

  • Article
  • Open Access
9 Citations
2,894 Views
12 Pages

Rapid Detection of Tannin Content in Wine Grapes Using Hyperspectral Technology

  • Peng Zhang,
  • Qiang Wu,
  • Yanhan Wang,
  • Yun Huang,
  • Min Xie and
  • Li Fan

21 March 2024

Wine grape quality is influenced by the variety and growing environment, and the quality of the grapes has a significant impact on the quality of the wine. Tannins are a crucial indicator of wine grape quality, and, therefore, rapid and non-destructi...

  • Article
  • Open Access
2 Citations
5,168 Views
28 Pages

Could Life Have Started on Mars? Planetary Conditions That Assemble and Destroy Protocells

  • Francesca C. A. Cary,
  • David W. Deamer,
  • Bruce F. Damer,
  • Sarah A. Fagents,
  • Kathleen C. Ruttenberg and
  • Stuart P. Donachie

20 March 2024

Early Mars was likely habitable, but could life actually have started there? While cellular life emerged from prebiotic chemistry through a pre-Darwinian selection process relevant to both Earth and Mars, each planet posed unique selection ‘hur...

  • Review
  • Open Access
4 Citations
2,639 Views
22 Pages

20 March 2024

Vine-growing for the production of wine is one of the oldest and most important agricultural activities worldwide, but the winemaking process leads to vast amounts of waste. Viticulture and vinification by-products have many bioactive molecules, incl...

  • Communication
  • Open Access
3 Citations
11,119 Views
10 Pages

20 March 2024

Nicotinamide adenine dinucleotide (NAD+) plays a pivotal role in various physiological processes within mammalian cells, including energy metabolism, redox homeostasis, and genetic regulation. In the majority of mammalian cellular contexts, NAD+ bios...

  • Article
  • Open Access
8 Citations
3,766 Views
17 Pages

Aerobic Exercise Modulates Proteomic Profiles in Gastrocnemius Muscle of db/db Mice, Ameliorating Sarcopenia

  • Yen-Chun Huang,
  • Monika Renuka Sanotra,
  • Chi-Chang Huang,
  • Yi-Ju Hsu and
  • Chen-Chung Liao

20 March 2024

Type-2 diabetes mellitus (T2DM)-induced sarcopenia is intertwined with diminished insulin sensitivity and extracellular matrix (ECM) remodeling in skeletal muscle and other organs. Physical activities such as aerobic exercise play a crucial role in r...

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Life - ISSN 2075-1729