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Life, Volume 14, Issue 4

April 2024 - 116 articles

Cover Story: The neglected Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi. Current treatment for CD relies on medications with strong side effects and reduced effectiveness. The unique characteristics and high adaptability of T. cruzi, its mechanisms of persistence, and evasion of the immune system seem to influence the course of the disease. Despite the efforts to uncover the pathology of CD, there are many gaps in understanding how it is established and reaches chronicity. We explain the background in which CD is established, from the peculiarities of T. cruzi molecular biology to the development of the host’s immune response leading to the pathophysiology of CD. We also discuss the state of the art of treatments for CD and current challenges in basic and applied science. View this paper
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Articles (116)

  • Review
  • Open Access
3 Citations
2,507 Views
21 Pages

DNA Methylation Machinery in Gastropod Mollusks

  • Laura Haidar,
  • Marius Georgescu,
  • George Andrei Drăghici,
  • Ioan Bănățean-Dunea,
  • Dragoș Vasile Nica and
  • Alina-Florina Șerb

22 April 2024

The role of DNA methylation in mollusks is just beginning to be understood. This review synthesizes current knowledge on this potent molecular hallmark of epigenetic control in gastropods—the largest class of mollusks and ubiquitous inhabitants...

  • Article
  • Open Access
1 Citations
2,284 Views
15 Pages

The Anti-Cholinesterase Potential of Fifteen Different Species of Narcissus L. (Amaryllidaceae) Collected in Spain

  • Luciana R. Tallini,
  • Giulia Manfredini,
  • María Lenny Rodríguez-Escobar,
  • Segundo Ríos,
  • Vanessa Martínez-Francés,
  • Gabriela E. Feresin,
  • Warley de Souza Borges,
  • Jaume Bastida,
  • Francesc Viladomat and
  • Laura Torras-Claveria

22 April 2024

Narcissus L. is a renowned plant genus with a notable center of diversity and is primarily located in the Mediterranean region. These plants are widely recognized for their ornamental value, owing to the beauty of their flowers; nonetheless, they als...

  • Article
  • Open Access
4 Citations
3,330 Views
14 Pages

Aflatoxins in Wheat Grains: Detection and Detoxification through Chemical, Physical, and Biological Means

  • Ahmed Mahmoud Ismail,
  • Muhammad Hassan Raza,
  • Naseem Zahra,
  • Rafiq Ahmad,
  • Yasar Sajjad and
  • Sabaz Ali Khan

22 April 2024

Wheat (Triticum aestivum L.) is an essential food crop in terms of consumption as well as production. Aflatoxin exposure has a widespread public health impact in economically developing nations, so there is a need to establish preventive techniq...

  • Article
  • Open Access
2,197 Views
10 Pages

Complete Mitochondrial Genome and Its Phylogenetic Position in Red Algae Fushitsunagia catenata from South Korea

  • Maheshkumar Prakash Patil,
  • Nur Indradewi Oktavitri,
  • Young-Ryun Kim,
  • Seokjin Yoon,
  • In-Cheol Lee,
  • Jong-Oh Kim and
  • Kyunghoi Kim

22 April 2024

The mitogenome is an important tool in taxonomic and evolutionary studies. Only a few complete mitogenomes have been reported for red algae. Herein, we reported the complete mitochondrial genome sequence of Fushitsunagia catenata (Harvey) Filloramo,...

  • Article
  • Open Access
2,153 Views
15 Pages

Looking into the Eyes to See the Heart of Chronic Kidney Disease Patients

  • Maria Kislikova,
  • Jorge Javier Gaitán-Valdizán,
  • José Antonio Parra Blanco,
  • María Teresa García Unzueta,
  • María Rodríguez Vidriales,
  • Clara Escagedo Cagigas,
  • Vicente Celestino Piñera Haces,
  • María de la Oliva Valentín Muñoz,
  • Adalberto Benito Hernández and
  • Juan Carlos Ruiz San Millan
  • + 1 author

22 April 2024

In patients with chronic kidney disease (CKD), the main cause of morbidity and mortality is cardiovascular disease (CVD). Both coronary artery calcium scoring by computed tomography (CT) and optical coherence tomography (OCT) are used to identify pat...

  • Article
  • Open Access
2 Citations
2,410 Views
11 Pages

Evaluating the Efficacy of Resect-and-Discard and Resect-and-Retrieve Strategies for Diminutive Colonic Polyps

  • Andrei Lucian Groza,
  • Bogdan Miutescu,
  • Cristian Tefas,
  • Alexandru Popa,
  • Iulia Ratiu,
  • Roxana Sirli,
  • Alina Popescu,
  • Alexandru Catalin Motofelea and
  • Marcel Tantau

21 April 2024

Background and Objectives: Diminutive polyps present a unique challenge in colorectal cancer (CRC) prevention strategies. This study aims to assess the characteristics and variables of diminutive polyps in a Romanian cohort, intending to develop a co...

  • Article
  • Open Access
3 Citations
2,235 Views
15 Pages

21 April 2024

The AMTI VIVO™ six degree of freedom joint simulator allows reproducible preclinical testing of joint endoprostheses under specific kinematic and loading conditions. When testing total knee endoprosthesis, the articulating femoral and tibial co...

  • Article
  • Open Access
2 Citations
2,374 Views
10 Pages

21 April 2024

We aim to investigate the potential correlation between the presence of ovarian cancer and the development of dry eye disease (DED) via the usage of the Longitudinal Health Insurance Database (LHID) of Taiwan. A retrospective cohort study was execute...

  • Article
  • Open Access
1 Citations
2,805 Views
12 Pages

Optimal Dietary Intake of Riboflavin Associated with Lower Risk of Cervical Cancer in Korea: Korean National Health and Nutrition Examination Survey 2010–2021

  • Seon-Mi Lee,
  • Aeran Seol,
  • Hyun-Woong Cho,
  • Kyung-Jin Min,
  • Sanghoon Lee,
  • Jin-Hwa Hong,
  • Jae-Yun Song,
  • Jae-Kwan Lee and
  • Nak-Woo Lee

20 April 2024

Background: This study aimed to evaluate the association between the dietary intake of vitamin B complex (thiamine, riboflavin, and niacin) and cervical cancer in Korea. Methods: The data from the Korean National Health and Nutrition Examination Surv...

  • Review
  • Open Access
2 Citations
2,650 Views
13 Pages

Botulinum Toxin in Chronic Lateral Epicondylitis, from Tendon to Muscle Approach—A Review

  • Daniela Poenaru,
  • Miruna Ioana Sandulescu,
  • Claudia-Gabriela Potcovaru and
  • Delia Cinteza

20 April 2024

Background: Chronic lateral epicondylitis challenges the therapeutical approach; underlying mechanisms are incompletely understood; neuropathic pain and central and peripheral sensitization may explain the fact that botulinum toxin has been found to...

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Life - ISSN 2075-1729Creative Common CC BY license