Table of Contents
Polymers, Volume 10, Issue 10 (October 2018)
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Cover Story (view full-size image) The photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive [...] Read more. The photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisting of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under exposure to 532-nm green laser, which resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a great extent. Such photothermo-responsive nanogels possess great potential in anti-cancer treatment. View the paper here.