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Polymers 2018, 10(10), 1150; https://doi.org/10.3390/polym10101150

A Phenolphthalein-Dummy Template Molecularly Imprinted Polymer for Highly Selective Extraction and Clean-Up of Bisphenol A in Complex Biological, Environmental and Food Samples

1,†
,
2,†
,
2,3
,
4
and
2,*
1
College of Materials Science and Engineering, Hebei University of Engineering, 199 South Guangming Street, Handan 056038, China
2
CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
3
University of Chinese Academy of Sciences, Beijing 100049, China
4
Inspection and Quarantine Technology Centre, Hunan Entry-Exit Inspection and Quarantine Bureau, Changsha 410004, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 13 September 2018 / Revised: 5 October 2018 / Accepted: 12 October 2018 / Published: 15 October 2018
Full-Text   |   PDF [2117 KB, uploaded 15 October 2018]   |  

Abstract

A molecularly imprinted polymer (MIP) for highly selective solid-phase extraction (SPE) of bisphenol A (BPA) was prepared using phenolphthalein (PP) as the novel dummy template by bulk polymerization. A particle diameter distribution of 40–60 μm, a specific surface area of 359.8 m2·g−1, and a total pore volume of 0.730 cm3·g−1 for the prepared PP-imprinted polymer (PPMIP) were obtained. Good selectivity and specific adsorption capacity for BPA of the prepared PPMIP were also demonstrated by the chromatographic evaluation and sorption experiments. The PPMIP as a SPE sorbent was evaluated for the selective extraction and clean-up of BPA from complex biological, environmental, and food samples. Meanwhile, an accurate and sensitive analytical method based on the PPMIP-SPE purification procedure coupled with high performance liquid chromatography-diode array detector (HPLC-DAD) detection has been successfully developed for the rapid determination of BPA from these samples, with detection limits of 1.3 ng·mL−1 for bovine serum and milk, 2.6 ng·mL−1 for human urine and edible oil, 5.2 ng·mL−1 for soybean sauce, and 1.3 ng·g−1 for sediment. The BPA recoveries at two different spiking levels were in the range of 82.1–106.9%, with relative standard deviation (RSD) values below 7.7%. View Full-Text
Keywords: molecularly imprinted polymer; dummy template; solid-phase extraction; bisphenol A; biological; environmental and food samples molecularly imprinted polymer; dummy template; solid-phase extraction; bisphenol A; biological; environmental and food samples
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yang, J.; Li, Y.; Huang, C.; Jiao, Y.; Chen, J. A Phenolphthalein-Dummy Template Molecularly Imprinted Polymer for Highly Selective Extraction and Clean-Up of Bisphenol A in Complex Biological, Environmental and Food Samples. Polymers 2018, 10, 1150.

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