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Polymers 2018, 10(10), 1164; https://doi.org/10.3390/polym10101164

Preparation of Microparticles Capable of Glucose-Induced Insulin Release under Physiological Conditions

1
School of Pharmaceutical Sciences, Ohu University 31-1 Misumido, Tomita-Machi, Koriyama, Fukushima 963-8611, Japan
2
Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
*
Author to whom correspondence should be addressed.
Received: 25 September 2018 / Revised: 17 October 2018 / Accepted: 17 October 2018 / Published: 18 October 2018
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Abstract

Hydrogen peroxide (H2O2)-sensitive layer-by-layer films were prepared based on combining phenyl boronic acid (PBA)-modified poly(allylamine) (PAH) with shikimic acid (SA)-modified-PAH through boronate ester bonds. These PBA-PAH/SA-PAH multilayer films could be prepared in aqueous solutions at pH 7.4 and 9.0 in the presence of NaCl. It is believed that the electrostatic repulsion between the SA-PAH and PBA-PAH was diminished and the formation of ester bonds between the SA and PBA was promoted in the presence of NaCl. These films readily decomposed in the presence of H2O2 because the boronate ester bonds were cleaved by an oxidation reaction. In addition, SA-PAH/PBA-PAH multilayer films combined with glucose oxidase (GOx) were decomposed in the presence of glucose because GOx catalyzes the oxidation of D-glucose to generate H2O2. The surfaces of CaCO3 microparticles were coated with PAH/GOx/(SA-PAH/PBA-PAH)5 films that absorbed insulin. A 1 mg quantity of these particles released up to 10 μg insulin in the presence 10 mM glucose under physiological conditions. View Full-Text
Keywords: phenyl boronic acid; hydrogen peroxide; drug delivery system; insulin; LbL film; glucose response phenyl boronic acid; hydrogen peroxide; drug delivery system; insulin; LbL film; glucose response
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Yoshida, K.; Awaji, K.; Shimizu, S.; Iwasaki, M.; Oide, Y.; Ito, M.; Dairaku, T.; Ono, T.; Kashiwagi, Y.; Sato, K. Preparation of Microparticles Capable of Glucose-Induced Insulin Release under Physiological Conditions. Polymers 2018, 10, 1164.

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