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Polymers 2018, 10(10), 1098; https://doi.org/10.3390/polym10101098

Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy

1
and
1,2,*
1
Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan
2
Advanced Research Center for Green Materials Science and Technology, National Taiwan University, Taipei 10617, Taiwan
*
Author to whom correspondence should be addressed.
Received: 17 September 2018 / Revised: 1 October 2018 / Accepted: 2 October 2018 / Published: 4 October 2018
(This article belongs to the Special Issue Smart Polymers)
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Abstract

Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment. View Full-Text
Keywords: nanogel; photothermo-responsive; N-isopropylacrylamide; sodium copper chlorophyllin; drug delivery; anti-cancer nanogel; photothermo-responsive; N-isopropylacrylamide; sodium copper chlorophyllin; drug delivery; anti-cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chang, R.; Tsai, W.-B. Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy. Polymers 2018, 10, 1098.

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