Next Article in Journal
Grafting Halloysite Nanotubes with Amino or Carboxyl Groups onto Carbon Fiber Surface for Excellent Interfacial Properties of Silicone Resin Composites
Next Article in Special Issue
Investigation on the Short-Term Aging-Resistance of Thermoplastic Polyurethane-Modified Asphalt Binders
Previous Article in Journal
High-Performance PEDOT:PSS/Hexamethylene Diisocyanate-Functionalized Graphene Oxide Nanocomposites: Preparation and Properties
Previous Article in Special Issue
A Mild Method for Surface-Grafting PEG Onto Segmented Poly(Ester-Urethane) Film with High Grafting Density for Biomedical Purpose
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle
Polymers 2018, 10(10), 1170; https://doi.org/10.3390/polym10101170

Synthesis and Characterization of Isosorbide-Based Polyurethanes Exhibiting Low Cytotoxicity Towards HaCaT Human Skin Cells

1
CERENA, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
2
Research Institute for Medicine and Pharmaceutical Science (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
3
Centro de Química Estrutural, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
*
Authors to whom correspondence should be addressed.
Received: 21 September 2018 / Revised: 12 October 2018 / Accepted: 17 October 2018 / Published: 20 October 2018
(This article belongs to the Special Issue Functional Polyurethanes)
Full-Text   |   PDF [5308 KB, uploaded 22 October 2018]   |  

Abstract

The synthesis of four samples of new polyurethanes was evaluated by changing the ratio of the diol monomers used, poly(propylene glycol) (PPG) and D-isosorbide, in the presence of aliphatic isocyanates such as the isophorone diisocyanate (IPDI) and 4,4′-methylenebis(cyclohexyl isocyanate) (HMDI). The thermal properties of the four polymers obtained were determined by DSC, exhibiting Tg values in the range 55–70 °C, and their molecular structure characterized by FTIR, 1H, and 13C NMR spectroscopies. The diffusion coefficients of these polymers in solution were measured by the Pulse Gradient Spin Echo (PGSE) NMR method, enabling the calculation of the corresponding hydrodynamic radii in diluted solution (1.62–2.65 nm). The molecular weights were determined by GPC/SEC and compared with the values determined by a quantitative 13C NMR analysis. Finally, the biocompatibility of the polyurethanes was assessed using the HaCaT keratinocyte cell line by the MTT reduction assay method showing values superior to 70% cell viability. View Full-Text
Keywords: biocompatibility; GPC/SEC; keratinocyte cells; NMR; polyurethane; renewable sources biocompatibility; GPC/SEC; keratinocyte cells; NMR; polyurethane; renewable sources
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Gregorí Valdés, B.S.; Gomes, C.S.B.; Gomes, P.T.; Ascenso, J.R.; Diogo, H.P.; Gonçalves, L.M.; Galhano dos Santos, R.; Ribeiro, H.M.; Bordado, J.C. Synthesis and Characterization of Isosorbide-Based Polyurethanes Exhibiting Low Cytotoxicity Towards HaCaT Human Skin Cells. Polymers 2018, 10, 1170.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top