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Polymers 2018, 10(10), 1165; https://doi.org/10.3390/polym10101165

Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials

1
Institute of Chemistry, University of Potsdam, D-14476 Potsdam, Germany
2
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland
3
Institute of Physics and Astronomy, University of Potsdam, D-14476 Potsdam, Germany
4
Institute of Biochemistry and Biology, University of Potsdam, D-14476 Potsdam, Germany
5
Institute for Applied Materials and Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology, D-76344 Eggenstein-Leopoldshafen, Germany
*
Authors to whom correspondence should be addressed.
Received: 28 August 2018 / Revised: 1 October 2018 / Accepted: 7 October 2018 / Published: 18 October 2018
(This article belongs to the Special Issue Hybrid Adhesive and Coatings for Medical Applications)
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Abstract

This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields. View Full-Text
Keywords: polymer brushes; calcium phosphate; hydroxyapatite; carbonated apatite; bone mimic; biocompatibility; Dictyostelium discoideum polymer brushes; calcium phosphate; hydroxyapatite; carbonated apatite; bone mimic; biocompatibility; Dictyostelium discoideum
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Mai, T.; Wolski, K.; Puciul-Malinowska, A.; Kopyshev, A.; Gräf, R.; Bruns, M.; Zapotoczny, S.; Taubert, A. Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials. Polymers 2018, 10, 1165.

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