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Cancers, Volume 17, Issue 7

April-1 2025 - 202 articles

Cover Story: Social determinants of health (SDOH) profoundly impact cancer care, influencing access to treatment, outcomes, and survivorship. These factors—ranging from socioeconomic status to geographic location—create significant disparities, often exacerbating cancer-related morbidity and mortality, particularly in underserved populations. Despite progress in cancer care, inequities persist, particularly for racial and ethnic minorities, the elderly, and those living in rural areas. The following review explores how SDOH affect cancer care and proposes targeted interventions to reduce disparities, promoting equitable care for all patients. View this paper
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Articles (202)

  • Review
  • Open Access
1 Citations
2,709 Views
24 Pages

6 April 2025

Cholangiocarcinoma (CCA) is an aggressive malignancy with limited methods for early detection, necessitating the development of reliable biomarkers for diagnosis and management. However, conventional tumor markers, such as CA19-9 and CEA, exhibit ins...

  • Article
  • Open Access
4 Citations
2,929 Views
18 Pages

Endoscopic Submucosal Dissection (ESD) for the Management of Fibrotic Non-Lifting Colorectal Lesions (NLCLs): Results from a Large Multicenter Retrospective Study

  • Giuseppe Dell’Anna,
  • Ernesto Fasulo,
  • Paolo Cecinato,
  • Giovanni Barbara,
  • Alberto Barchi,
  • Edi Viale,
  • Dario Esposito,
  • Simone Grillo,
  • Romano Sassatelli and
  • Alberto Malesci
  • + 7 authors

6 April 2025

Background/Objectives: The management of non-lifting colorectal lesions (NLCLs), often resulting from previous unsuccessful treatments or biopsies, remains challenging due to submucosal fibrosis that prevents adequate lifting. Endoscopic submucosal d...

  • Article
  • Open Access
1 Citations
2,251 Views
17 Pages

6 April 2025

Objectives: We aimed to study the efficacy of fractional CO2 laser for genitourinary syndrome of menopause (GSM) symptoms in breast cancer (BC) survivors through a randomized, sham-controlled study, followed by an open-phase study assessing the impac...

  • Article
  • Open Access
1 Citations
827 Views
16 Pages

Intraoperative Radiation Therapy for Gynecologic Malignancies: When Is It Indicated?

  • Flavia Pagano,
  • Flurina Annacarina Maria Saner,
  • Codruta Ionescu,
  • Elena Riggenbach,
  • Kristina Lössl,
  • Franziska Siegenthaler,
  • Michael David Mueller and
  • Sara Imboden

6 April 2025

Background: Intraoperative radiation therapy (IORT) is the delivery of a single large dose of radiation to a limited volume of tissue at the time of surgery. The aim of this study is to assess outcomes in patients who underwent IORT for gynecologic m...

  • Article
  • Open Access
1 Citations
1,317 Views
14 Pages

Evaluating the Potential of PSMA Targeting in CNS Tumors: Insights from Large-Scale Transcriptome Profiling

  • Adam Kraya,
  • Komal Rathi,
  • Run Jin,
  • Varun Kesherwani,
  • Adam C. Resnick,
  • Phillip B. Storm and
  • Ali Nabavizadeh

6 April 2025

Background/Objectives: Prostate-specific membrane antigen (PSMA) is a well-established target in prostate cancer therapy that has shown potential as a theranostic target across non-central nervous system (CNS) and CNS tumor types. We aimed to investi...

  • Article
  • Open Access
1 Citations
1,467 Views
20 Pages

Psychosocial Outcomes in Parents of Children with Acute Lymphoblastic Leukaemia in Australia and New Zealand Through and Beyond Treatment

  • Clare Parker,
  • Clarissa E. Schilstra,
  • Karen McCleary,
  • Michelle Martin,
  • Toby N. Trahair,
  • Rishi S. Kotecha,
  • Shanti Ramachandran,
  • Ruellyn Cockcroft,
  • Rachel Conyers and
  • Siobhan Cross
  • + 8 authors

6 April 2025

Background/Objectives: Parents of children with acute lymphoblastic leukaemia (ALL) experience emotional distress throughout their child’s treatment course. This study describes the psychological experience of Australian and New Zealand parents...

  • Article
  • Open Access
1 Citations
1,266 Views
16 Pages

Perioperative and Mid-Term Oncological and Functional Outcomes After Partial Nephrectomy for Entirely Endophytic Renal Tumors: A Prospective Multicenter Observational Study (The RECORD2 Project)

  • Fabrizio Di Maida,
  • Andrea Mari,
  • Daniele Amparore,
  • Alessandro Antonelli,
  • Riccardo Schiavina,
  • Riccardo Giuseppe Bertolo,
  • Alessandro Veccia,
  • Eugenio Brunocilla,
  • Riccardo Campi and
  • Luigi Da Pozzo
  • + 14 authors

5 April 2025

Background and Objectives: Totally endophytic renal tumors are a unique subset that pose significant technical challenges during partial nephrectomy (PN). The aim of this study was to evaluate the perioperative, oncologic, and functional outcomes of...

  • Article
  • Open Access
1 Citations
1,936 Views
17 Pages

Trends in Overall Survival in Lung Adenocarcinoma with EGFR Mutation, KRAS Mutation, or No Mutation

  • Martin Faehling,
  • Sabine Fallscheer,
  • Birgit Schwenk,
  • Harald Seifarth,
  • Jörn Sträter,
  • Claudia Lengerke and
  • Petros Christopoulos

5 April 2025

Background: Treatment of lung adenocarcinoma has changed and now includes checkpoint inhibitors (CPIs) or, in the case of an EGFR mutation, third-generation EGFR TKI osimertinib. Few data compare the long-term overall survival (OS) of current and his...

  • Systematic Review
  • Open Access
2 Citations
3,045 Views
37 Pages

Real-World Evidence Evaluating Teclistamab in Patients with Relapsed/Refractory Multiple Myeloma: A Systematic Literature Review

  • Benjamin Derman,
  • Carlyn Tan,
  • Ian Steinfield,
  • Florence R. Wilson,
  • Dee Lin,
  • Bingcao Wu,
  • Mariana Fernandez,
  • Jessica Fowler,
  • Agne Paner-Straseviciute and
  • Nina Kim
  • + 5 authors

5 April 2025

Background: Teclistamab (TEC) is the first B-cell maturation antigen-directed bispecific antibody approved in 2022 by the European Medicines Agency and Food and Drug Administration for triple-class exposed relapsed/refractory multiple myeloma (RRMM)....

  • Article
  • Open Access
2 Citations
1,291 Views
27 Pages

Pro-Inflammatory Cytokines Transactivate Glycosylated Cytokine Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition to the Metastatic Phenotype

  • Leili Baghaie,
  • David A. Bunsick,
  • Emilyn B. Aucoin,
  • Elizabeth Skapinker,
  • Abdulrahman M. Yaish,
  • Yunfan Li,
  • William W. Harless and
  • Myron R. Szewczuk

5 April 2025

Background/Objectives: The significance of cytokine signaling on cancer progression and metastasis has raised interest in cancer research over the last few decades. Here, we analyzed the effects of three cytokines that we previously reported are sign...

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Cancers - ISSN 2072-6694