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Cancers, Volume 17, Issue 6

March-2 2025 - 141 articles

Cover Story: In the following study, patients with metastatic, non-oncogene-addicted NSCLC received anti-PD1-based therapies. These treatments targeted various immune system components and affected the interactions among these factors to differing degrees. Responding patients with better clinical status exhibited an immune profile characterized by low connections primarily among soluble checkpoints at baseline. Non-responders with worse clinical status showed a complex immune network involving inflammatory cytokines, cellular components, and soluble checkpoints. Defining the connectivity among the molecules of each profile serves as an optimal starting point for developing combinatory targeted drugs aimed at optimizing therapeutic strategies and avoiding unnecessary and toxic treatments. View this paper
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Articles (141)

  • Article
  • Open Access
947 Views
16 Pages

Multi-Modal Machine Learning for Evaluating the Predictive Value of Pelvimetric Measurements (Pelvimetry) for Anastomotic Leakage After Restorative Low Anterior Resection

  • Ritch T. J. Geitenbeek,
  • Simon C. Baltus,
  • Mark Broekman,
  • Sander N. Barendsen,
  • Maike C. Frieben,
  • Ilias Asaggau,
  • Elina Thibeau-Sutre,
  • Jelmer M. Wolterink,
  • Matthijs C. Vermeulen and
  • Can O. Tan
  • + 2 authors

20 March 2025

Background/Objectives: Anastomotic leakage (AL) remains a major complication after restorative rectal cancer surgery, with accurate preoperative risk stratification posing a significant challenge. Pelvic measurements derived from magnetic resonance i...

  • Review
  • Open Access
2,545 Views
16 Pages

The Role of 18F PSMA-1007 PET/CT in the Staging and Detection of Recurrence of Prostate Cancer, A Scoping Review

  • David Armany,
  • Lequang Vo,
  • Duncan Self,
  • Sriskanthan Baskaranathan,
  • Tania Hossack,
  • Simon Bariol,
  • David Ende and
  • Henry Hyunshik Woo

20 March 2025

Background: To determine and review the currently available literature behind the staging capabilities of 18F-PSMA-1007 PET/CT in the setting of initial staging and detection of recurrent disease for patients with prostate cancer. Prostate cancer (PC...

  • Review
  • Open Access
1 Citations
2,285 Views
14 Pages

Daylight Photodynamic Therapy for Actinic Keratosis and Field Cancerization: A Narrative Review

  • Elena Sotiriou,
  • Dimitra Kiritsi,
  • Nikolaos Chaitidis,
  • Michael Arabatzis,
  • Aimilios Lallas and
  • Efstratios Vakirlis

20 March 2025

Actinic keratoses (AKs), also known as solar keratoses, are rough, scaly lesions that appear as macules, papules, or plaques [...]

  • Article
  • Open Access
2 Citations
724 Views
27 Pages

Impact of Surgical Resection After Induction Gemcitabine Plus S-1-Based Chemoradiotherapy in Patients with Locally Advanced Pancreatic Ductal Adenocarcinoma: A Focus on UR-LA Cases

  • Masashi Kishiwada,
  • Shugo Mizuno,
  • Aoi Hayasaki,
  • Benson Kaluba,
  • Takehiro Fujii,
  • Daisuke Noguchi,
  • Takahiro Ito,
  • Yusuke Iizawa,
  • Akihiro Tanemura and
  • Yasuhiro Murata
  • + 1 author

20 March 2025

Background: This study aimed to assess the safety and efficacy of gemcitabine plus S-1-based chemoradiotherapy (GS-CRT) among patients with locally advanced pancreatic ductal adenocarcinoma (PDAC), especially among those with unresectable locally adv...

  • Article
  • Open Access
1,252 Views
19 Pages

Diagnostic Performance of Combined Conventional CT Imaging Features and Radiomics Signature in Differentiating Grade 1 Tumors from Higher-Grade Pancreatic Neuroendocrine Neoplasms

  • Florent Tixier,
  • Felipe Lopez-Ramirez,
  • Alejandra Blanco,
  • Ammar A. Javed,
  • Linda C. Chu,
  • Ralph H. Hruban,
  • Mohammad Yasrab,
  • Daniel Fadaei Fouladi,
  • Shahab Shayesteh and
  • Saeed Ghandili
  • + 2 authors

20 March 2025

Background/Objectives: Accurate identification of grade 1 (G1) pancreatic neuroendocrine tumors (PanNETs) is crucial due to their rising incidence and emerging nonsurgical management strategies. This study evaluated whether combining conventional CT...

  • Article
  • Open Access
3 Citations
2,063 Views
12 Pages

Proton Craniospinal Irradiation for Patients with Solid Tumor Leptomeningeal Disease: Real-World Feasibility, Toxicity, and Outcome Analysis

  • Omer Gal,
  • Alonso La Rosa,
  • Matthew D. Hall,
  • Robert H. Press,
  • Zachary Fellows,
  • Andrew J. Wroe,
  • Alonso N. Gutierrez,
  • Yazmin Odia,
  • Minesh P. Mehta and
  • Rupesh Kotecha

20 March 2025

Leptomeningeal disease (LMD) is a devastating clinical scenario in patients with metastatic cancer [...]

  • Article
  • Open Access
1,224 Views
10 Pages

The Role and Potential of Modern Radiotherapy in the Treatment of Metastatic Prostate Cancer

  • Robert Kwiatkowski,
  • Anna M. Kłeczek,
  • Jadwiga Gabor,
  • Natalia Brzezińska and
  • Andrzej S. Swinarew

20 March 2025

Background/Objectives: Prostate cancer is one of the most prevalent cancers among men, with a significant proportion progressing to metastatic disease. Traditional treatments for metastatic prostate cancer have primarily been palliative, focusing on...

  • Review
  • Open Access
4 Citations
3,305 Views
19 Pages

The Gut–Endometrium Axis: Exploring the Role of Microbiome in the Pathogenesis and Treatment of Endometrial Cancer—A Narrative Review

  • Beibei Zhang,
  • Nur Fatin Nabilah Mohd Sahardi,
  • Wen Di,
  • Xiaoran Long and
  • Mohamad Nasir Shafiee

20 March 2025

Background/Objectives: Endometrial cancer (EC) is a prevalent gynecological malignancy with an increasing incidence, particularly in developed countries. Recent research has demonstrated the significant involvement of gut and endometrial microbiomes...

  • Article
  • Open Access
837 Views
16 Pages

Mixed-Methods Approach: Impact of Clinical Consenter Diversity on Clinical Trials Enrollment

  • Angelica Sanchez,
  • Christina M. Vidal,
  • Noé Rubén Chávez,
  • Nikita Jinna,
  • Jackelyn Alva-Ornelas,
  • Vanessa Myriam Robles,
  • Cristal Resto,
  • Nancy Sanchez,
  • Dana Aljaber and
  • Margarita Monge
  • + 7 authors

20 March 2025

Background: Clinical trials should benefit all people. Consequently, the National Cancer Institute expects cancer centers to accrue individuals to clinical trials in proportion to the cancer burden experienced by populations that live in their respec...

  • Review
  • Open Access
5 Citations
2,435 Views
19 Pages

Clinical Characteristics and Management of Ocular Metastases

  • Karolina Gerba-Górecka,
  • Bożena Romanowska-Dixon,
  • Izabella Karska-Basta,
  • Ewelina Cieplińska-Kechner and
  • Michał S. Nowak

20 March 2025

Intraocular metastases represent the most common type of intraocular tumors in adults. In most cases, the metastases originate from primary breast and lung cancers. Effective management of patients with intraocular metastatic disease requires a multi...

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Cancers - ISSN 2072-6694Creative Common CC BY license