Table of Contents
Cancers, Volume 11, Issue 1 (January 2019)
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Cover Story (view full-size image) NK cells are cytotoxic immune cells with an innate capability of eliminating cancer cells. They are [...] Read more. NK cells are cytotoxic immune cells with an innate capability of eliminating cancer cells. They are present in all steps of the metastatic cascade and play a central role in the control of metastasis. However, metastatic cells develop the most refined de facto immunosubversive mechanisms, thereby increasing the probability of malignant dissemination. The key role of NK cells in the control of metastasis provides an opportunity for immunotherapeutic intervention in cancer patients. Current therapeutic approaches include the adoptive transfer of NK cells, the boosting of NK cell activity with stimulating cytokines and drugs, the redirection of NK cell activity against metastatic cells, and the release of evasion mechanisms dampening NK cell immunosurveillance. Now, the challenge is to translate the increasing amount of preclinical cancer research into new therapeutic strategies. View this paper