Table of Contents
Cancers, Volume 11, Issue 2 (February 2019)
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Cover Story (view full-size image) Tumour hypoxia is a feature of solid tumours that contributes to poor prognosis after treatment, [...] Read more. Tumour hypoxia is a feature of solid tumours that contributes to poor prognosis after treatment, due to increased resistance of hypoxic cells to radio- and chemotherapy, and increased metastasis incidence. The extent of hypoxia within a tumour is influenced by the tolerance of individual tumour cells to hypoxia, a feature that differs considerably between tumours. High numbers of hypoxic cells are a direct consequence of enhanced cellular capability to activate HIF-1α signalling, the unfolded protein response (UPR) and autophagy. Recent evidence indicates that hypoxia tolerance can be modulated by distant cells that have experienced hypoxia, and is mediated by the systemic release of factors, such as extracellular vesicles (EV) that can alter HIF-1α-, UPR-, angiogenesis- and autophagy signalling. View this paper