Table of Contents
Cancers, Volume 10, Issue 12 (December 2018)
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Cover Story (view full-size image) The resistance of cancer cells to commonly used therapeutics is a key clinical challenge. The [...] Read more. The resistance of cancer cells to commonly used therapeutics is a key clinical challenge. The behaviour of cancer cells is influenced by their environment, which evolves along with tumor progression. Chemoresistance can be stimulated by elements of the tumor microenvironment, including extracellular matrix proteins, hypervascularization, hypoxia, and paracrine factors. This environment is generated by cancer cells and other associated cells, and is notable for its self-maintenance behaviour, which exacerbates tumor development. Through a network of interactions, environmental cues promote cancer cell proliferation and the epithelial–mesenchymal transition, and affect drug availability, leading to a chemoresistant phenotype. This review discusses the self-perpetuating tumor microenvironment and its effects on chemoresistance. View this paper