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Oral Administration of Fermented Papaya (FPP®) Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response

1
Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
2
Centro Nazionale Sperimentazione e Benessere Animale, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2019, 11(1), 118; https://doi.org/10.3390/cancers11010118
Received: 17 December 2018 / Revised: 16 January 2019 / Accepted: 18 January 2019 / Published: 20 January 2019
Prolonged oxidative stress may play a key role in tumor development. Antioxidant molecules are contained in many foods and seem to have a potential role in future anti-tumor strategies. Among the natural antioxidants the beneficial effect of Fermented Papaya (FPP®) is well known. The aim of this study was to investigate the effects of orally administered FPP® in either the prevention or treatment of a murine model of melanoma. The tumor growth was analyzed together with the blood levels of both oxidants (ROS) and anti-oxidants (SOD-1 and GSH). The results showed that FPP® controlled tumor growth, reducing the tumor mass of about three to seven times vs. untreated mice. The most significant effect was obtained with sublingual administration of FPP® close to the inoculation of melanoma. At the time of the sacrifice none of mice treated with FPP® had metastases and the subcutaneous tumors were significantly smaller and amelanotic, compared to untreated mice. Moreover, the FPP® anti-tumor effect was consistent with the decrease of total ROS levels and the increase in the blood levels of GSH and SOD-1. This study shows that a potent anti-oxidant treatment through FPP® may contribute to both preventing and inhibiting tumors growth. View Full-Text
Keywords: FPP®; tumor; prevention; adjuvant treatment; anti-oxidant effect FPP®; tumor; prevention; adjuvant treatment; anti-oxidant effect
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MDPI and ACS Style

Logozzi, M.; Mizzoni, D.; Di Raimo, R.; Macchia, D.; Spada, M.; Fais, S. Oral Administration of Fermented Papaya (FPP®) Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response. Cancers 2019, 11, 118. https://doi.org/10.3390/cancers11010118

AMA Style

Logozzi M, Mizzoni D, Di Raimo R, Macchia D, Spada M, Fais S. Oral Administration of Fermented Papaya (FPP®) Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response. Cancers. 2019; 11(1):118. https://doi.org/10.3390/cancers11010118

Chicago/Turabian Style

Logozzi, Mariantonia, Davide Mizzoni, Rossella Di Raimo, Daniele Macchia, Massimo Spada, and Stefano Fais. 2019. "Oral Administration of Fermented Papaya (FPP®) Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response" Cancers 11, no. 1: 118. https://doi.org/10.3390/cancers11010118

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