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Micromachines, Volume 9, Issue 7 (July 2018)
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Cover Story (view full-size image) Circulating biomarkers (CBs) such as exosome and cell-free DNA (cfDNA) are present in saliva and [...] Read more. Circulating biomarkers (CBs) such as exosome and cell-free DNA (cfDNA) are present in saliva and reflect the cancer status of patients. The salivary CBs can be obtained non-invasively using simple collecting methods like swab sucking. However, since the concentration of CBs in saliva is lower than that in blood, it is important to enrich CBs before analysis. Microfluidic technology is a promising tool for integrating saliva pretreatment, enrichment and detection of CBs on a single chip at high throughput sensitivity. By analyzing salivary CBs through microfluidic platform, clinical cancer research may progress more rapidly and efficiently. View this paper.