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Fabrication of Magnetically Actuated Fluidic Drug Delivery Device Using Polyvinyl Chloride Adhesive Stencils

1 and 1,2,*
1
Department of Electrical and Computer Engineering, Inter-University Semiconductor Research Center, Institute of Engineering Research, Seoul National University, Seoul 151-742, Korea
2
Department of Ophthalmology, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Korea
*
Author to whom correspondence should be addressed.
Micromachines 2018, 9(7), 358; https://doi.org/10.3390/mi9070358
Received: 30 May 2018 / Revised: 13 July 2018 / Accepted: 17 July 2018 / Published: 19 July 2018
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PDF [16527 KB, uploaded 19 July 2018]
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Abstract

In this paper, a polydimethylsiloxane (PDMS) fabrication method is introduced. It eliminates the need for conventional fabrication methods, such as photolithography and etching. Only a series of oxygen plasma treatments, silanization, and polyvinyl chloride (PVC) adhesive stencils were used to develop multi-layer designs. The fabrication method was applied to fabricate a PDMS-based drug delivery device with an actively controllable, magnetically actuated valve. Above all, this fabrication method eliminated the use of a power-consuming pump. Fluidic substances were injected into the circular shaped primary chamber through a syringe. A secondary chamber, similar to the primary chamber’s structure but with a smaller radius and thinner membrane, was connected via a microchannel to regulate the amount released. When actuated with a permanent magnet for one second, the volume in the secondary chamber first depletes. As the magnet is removed, the valve closes. Subsequently, the primary chamber replenishes the secondary chamber. This process can be repeated until the primary chamber reaches a saturation state that can no longer inflate the secondary chamber. The device could release a few microliters per actuation. Various combinations of size and thickness of primary, and secondary chambers can realize release rate of desired amount. View Full-Text
Keywords: fluidic drug delivery device; polyvinyl chloride adhesive stencil; polydimethylsiloxane fabrication; magnetically actuated microfluidic device; controlled release rate fluidic drug delivery device; polyvinyl chloride adhesive stencil; polydimethylsiloxane fabrication; magnetically actuated microfluidic device; controlled release rate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kim, H.; Seo, J.-M. Fabrication of Magnetically Actuated Fluidic Drug Delivery Device Using Polyvinyl Chloride Adhesive Stencils. Micromachines 2018, 9, 358.

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