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Toxins, Volume 11, Issue 4

April 2019 - 55 articles

Cover Story: Following ingestion of Shiga toxin-producing bacteria, the organisms attach or invade the intestinal epithelium and secrete toxins. Shiga toxins are translocated across the intestinal mucosa and enter the bloodstream. Immune cells, including neutrophils and monocytes, may act as toxin “carrier cells”. In target organs such as the kidneys and brain, the toxins are transferred to endothelial cells, expressing high affinity glycolipid toxin receptors, resulting in systemic disease, such as diarrhea-associated hemolytic uremic syndrome and CNS abnormalities. The innate immune response may be activated in each step of toxin transport to contribute to pathology. View this paper.
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Articles (55)

  • Article
  • Open Access
37 Citations
5,905 Views
16 Pages

Fumonisin Production by Fusarium verticillioides in Maize Genotypes Cultivated in Different Environments

  • Oelton Ferreira Rosa Junior,
  • Mateus Sunti Dalcin,
  • Vitor L. Nascimento,
  • Fernando Machado Haesbaert,
  • Talita Pereira de Souza Ferreira,
  • Rodrigo Ribeiro Fidelis,
  • Renato de Almeida Sarmento,
  • Raimundo Wagner de Souza Aguiar,
  • Eugenio Eduardo de Oliveira and
  • Gil Rodrigues dos Santos

10 April 2019

Fumonisins are mycotoxins (MTs) produced mainly by the fungus Fusarium verticillioides, the main pathogens of maize which cause ear rot. The aim of this work was to evaluate some factors that may lead to high fumonisin production by F. verticillioide...

  • Article
  • Open Access
33 Citations
6,272 Views
18 Pages

Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii

  • Rogério Coutinho das Neves,
  • Márcia Renata Mortari,
  • Elisabeth Ferroni Schwartz,
  • André Kipnis and
  • Ana Paula Junqueira-Kipnis

10 April 2019

Intravascular stent infection is a rare complication with a high morbidity and high mortality; bacteria from the hospital environment form biofilms and are often multidrug-resistant (MDR). Antimicrobial peptides (AMPs) have been considered as alterna...

  • Article
  • Open Access
26 Citations
6,148 Views
11 Pages

Assessment of Toxic Effects of Ochratoxin A in Human Embryonic Stem Cells

  • Slaven Erceg,
  • Eva María Mateo,
  • Iván Zipancic,
  • Francisco Javier Rodríguez Jiménez,
  • María Amparo Pérez Aragó,
  • Misericordia Jiménez,
  • José Miguel Soria and
  • Mª Ángeles Garcia-Esparza

10 April 2019

Ochratoxin A (OTA) is a mycotoxin produced by different Aspergillus and Penicillium species, and it is considered a common contaminant in food and animal feed worldwide. On the other hand, human embryonic stem cells (hESCs) have been suggested as a v...

  • Review
  • Open Access
70 Citations
13,981 Views
26 Pages

Roles of Shiga Toxins in Immunopathology

  • Moo-Seung Lee and
  • Vernon L. Tesh

9 April 2019

Shigella species and Shiga toxin-producing Escherichia coli (STEC) are agents of bloody diarrhea that may progress to potentially lethal complications such as diarrhea-associated hemolytic uremic syndrome (D+HUS) and neurological disorders. The bacte...

  • Review
  • Open Access
119 Citations
13,337 Views
13 Pages

The Key Role of Phosphate on Vascular Calcification

  • Mario Cozzolino,
  • Paola Ciceri,
  • Andrea Galassi,
  • Michela Mangano,
  • Stefano Carugo,
  • Irene Capelli and
  • Giuseppe Cianciolo

9 April 2019

Vascular calcification (VC) is common in dialysis and non-dialysis chronic kidney disease (CKD) patients, even in the early stage of the disease. For this reason, it can be considered a CKD hallmark. VC contributes to cardiovascular disease (CVD) and...

  • Article
  • Open Access
33 Citations
5,417 Views
14 Pages

Fluorescence Spectroscopic Investigation of Competitive Interactions between Quercetin and Aflatoxin B1 for Binding to Human Serum Albumin

  • Hongxia Tan,
  • Lu Chen,
  • Liang Ma,
  • Shuang Liu,
  • Hongyuan Zhou,
  • Yuhao Zhang,
  • Ting Guo,
  • Wei Liu,
  • Hongjie Dai and
  • Yong Yu

9 April 2019

Aflatoxin B1 (AFB1) is a highly toxic mycotoxin found worldwide in cereals, food, and animal feeds. AFB1 binds to human serum albumin (HSA) with high affinity. In previous experiments, it has been revealed that reducing the binding rate of AFB1 with...

  • Article
  • Open Access
18 Citations
5,831 Views
11 Pages

Combined Effects of Isokinetic Training and Botulinum Toxin Type A on Spastic Equinus Foot in Patients with Chronic Stroke: A Pilot, Single-blind, Randomized Controlled Trial

  • Nicoletta Cinone,
  • Sara Letizia,
  • Luigi Santoro,
  • Salvatore Facciorusso,
  • Raffaella Armiento,
  • Alessandro Picelli,
  • Maurizio Ranieri and
  • Andrea Santamato

8 April 2019

Botulinum toxin A (BoNT-A) has been shown effective for poststroke lower limb spasticity. Following injections, a wide range of multidisciplinary approach has been previously provided. The purpose of this pilot, single-blind, randomized controlled tr...

  • Article
  • Open Access
2 Citations
3,972 Views
13 Pages

15N Stable Isotope Labeling PSTs in Alexandrium minutum for Application of PSTs as Biomarker

  • Wancui Xie,
  • Min Li,
  • Lin Song,
  • Rui Zhang,
  • Xiaoqun Hu,
  • Chengzhu Liang and
  • Xihong Yang

8 April 2019

The dinoflagellate Alexandrium minutum (A. minutum) which can produce paralytic shellfish toxins (PSTs) is often used as a model to study the migration, biotransformation, accumulation, and removal of PSTs. However, the mechanism is still unclear. To...

  • Review
  • Open Access
16 Citations
5,227 Views
18 Pages

7 April 2019

Chronic kidney disease (CKD) is a major public health problem, since 300,000,000 people in the world display a glomerular filtration rate (GFR) below 60 mL/min/1.73m2. Patients with CKD have high rates of complications and comorbidities. Thus, they r...

  • Article
  • Open Access
3 Citations
4,226 Views
14 Pages

6 April 2019

Toxin–antitoxin (TA) systems are diverse genetic modules with demonstrated roles in plasmid stability, stress management, biofilm formation and antibiotic persistence. However, relatively little is known about their functional significance in p...

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Toxins - ISSN 2072-6651