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Journal of Xenobiotics, Volume 14, Issue 1

2024 March - 26 articles

Cover Story: Spironolactone (SPI) is a diuretic widely used to treat cardiovascular diseases. It was lately identified as an endocrine-disrupting compound (EDC) in female western mosquitofish, but no data evaluated its disruptive actions at the vascular level with possible impairments for human health. We analysed the contractility effects of SPI on rat aorta and its mode of action by Ca2+ channels and endothelial pathways, and performed cytotoxic assays. Data show that SPI-induced vasodilation is partially mediated by endothelium-dependent (involving nitric oxide) and -independent mechanisms (Ca2+ channels blockage). A non-monotonic effect characteristic of EDC was also observed for an SPI-induced decrease in smooth muscle cell viability. In summary, despite our study being performed with animal arteries, our findings suggest that SPI may have implications for human vascular health, possibly… View this paper
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Articles (26)

  • Review
  • Open Access
38 Citations
12,934 Views
36 Pages

20 March 2024

Biochar (BC), also referred to as “black gold”, is a carbon heterogeneous material rich in aromatic systems and minerals, preparable by the thermal decomposition of vegetable and animal biomasses in controlled conditions and with clean te...

(This article belongs to the Special Issue Feature Papers in Ecotoxicology)
  • Article
  • Open Access
1 Citations
3,898 Views
12 Pages

14 March 2024

Autism spectrum disorder (ASD) is a behaviorally defined neurodevelopmental disorder characterized by deficits in language, communication, and social function with an estimated prevalence rate of between 1 in 30 and 44 U.S. births. Gene/environment (...

  • Review
  • Open Access
5 Citations
8,169 Views
24 Pages

13 March 2024

Mast cells (MCs) are immune cells that reside in tissues; particularly in the skin, and in the gastrointestinal and respiratory tracts. In recent years, there has been considerable interest in the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2),...

(This article belongs to the Section Natural Products/Herbal Medicines)
  • Article
  • Open Access
6 Citations
4,308 Views
12 Pages

Air Pollution and Primary DNA Damage among Zagreb (Croatia) Residents: A Cross-Sectional Study

  • Marko Gerić,
  • Gordana Pehnec,
  • Katarina Matković,
  • Jasmina Rinkovec and ,
  • Ivana Jakovljević,
  • Ranka Godec,
  • Silva Žužul,
  • Ivan Bešlić,
  • Ante Cvitković and
  • Goran Gajski
  • + 9 authors+ 4 authors

13 March 2024

More than eight million premature deaths annually can be attributed to air pollution, with 99% of the world’s population residing in areas below recommended air quality standards. Hence, the present study aimed to examine the association betwee...

(This article belongs to the Topic Disease Risks and Toxic Pathway from Environmental Chemical Exposure)
  • Article
  • Open Access
6 Citations
15,597 Views
18 Pages

Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children

  • Raymond F. Palmer,
  • David Kattari,
  • Rodolfo Rincon and
  • Claudia S. Miller

5 March 2024

Background: We sought to replicate our 2015 findings linking chemical intolerance in parents with the risk of their children developing autism and/or ADHD. Drawing upon our 2021 discovery of a strong association between chemical intolerance and mast...

  • Article
  • Open Access
42 Citations
6,920 Views
17 Pages

Mitigation of Salt Stress in Rice by the Halotolerant Plant Growth-Promoting Bacterium Enterobacter asburiae D2

  • Zican Ning,
  • Kexin Lin,
  • Mengya Gao,
  • Xiao Han and ,
  • Qingjie Guan,
  • Xiang Ji,
  • Shuyu Yu and
  • Lei Lu
  • + 3 authors+ 0 author

1 March 2024

Salinity is a major abiotic stress that seriously affects crop growth worldwide. In this work, we aimed to isolate potential halotolerant plant growth-promoting rhizobacteria (PGPR) to mitigate the adverse impacts of salt stress in rice. An isolate,...

(This article belongs to the Special Issue Plant Biostimulants—a Promising Tool in Organic Farming)
  • Article
  • Open Access
3 Citations
4,434 Views
13 Pages

1 March 2024

Background: Spironolactone (SPI) is a diuretic widely used to treat cardiovascular diseases (CVD) and is non-specific for mineralocorticoid receptors (MR) and with an affinity for progesterone (PR) and androgen (AR) receptors. Since 2009, it has been...

  • Article
  • Open Access
2 Citations
2,742 Views
12 Pages

Xenobiotics Triggering Acute Intermittent Porphyria and Their Effect on Mouse Brain Respiratory Complexes

  • Johanna Romina Zuccoli,
  • María del Carmen Martínez,
  • Pablo Vallecorsa and
  • Ana María Buzaleh

27 February 2024

Heme enzyme dysfunction causes a group of diseases called porphyrias. Particularly, a decrease in porphobilinogen deaminase, involved in the third step of heme biosynthesis, leads to acute intermittent porphyria (AIP). Considering our previous works...

  • Article
  • Open Access
6 Citations
4,088 Views
13 Pages

The Complete Genome Sequence of Bacillus toyonensis Cbmb3 with Polyvinyl Chloride-Degrading Properties

  • Dandan Wang,
  • Hong Yu,
  • Xinbei Liu,
  • Li Sun and ,
  • Xijian Liu,
  • Ruilong Hu,
  • Chao Wang,
  • Yuping Zhuge and
  • Zhihong Xie
  • + 4 authors+ 0 author

26 February 2024

The accumulation of high amounts of plastic waste in the environment has raised ecological and health concerns, particularly in croplands, and biological degradation presents a promising approach for the sustainable treatment of this issue. In this s...

(This article belongs to the Special Issue Microplastics in Soils: Occurrence, Sources, Contaminant Vectors, and Effects on Soil Properties)
  • Article
  • Open Access
8 Citations
2,822 Views
10 Pages

22 February 2024

Nanobiomaterials (NBMs) have tremendous potential applications including in cancer diagnosis and treatment. However, the health and environmental effects of NBMs must be thoroughly assessed to ensure safety. Fe3O4 (magnetite) nanoparticles coated wit...

(This article belongs to the Section Ecotoxicology)
  • Article
  • Open Access
3 Citations
3,217 Views
18 Pages

The Effect of Granulometry of Carbonaceous Materials and Application Rates on the Availability of Soil-Bound Dichlorodiphenyltrichloroethane (DDT) and Its Metabolites

  • Farida Amutova,
  • Ronagul Turganova,
  • Gaukhar Konuspayeva,
  • Sarra Gaspard and ,
  • Aigerim Mamirova,
  • Florentin Michaux,
  • Pamela Hartmeyer,
  • Claire Soligot,
  • Leyla Djansugurova and
  • Matthieu Delannoy
  • + 6 authors+ 1 author

11 February 2024

Biochars (BCs) and activated carbons (ACs) are well-known carbon-rich materials that are being increasingly studied in environmental sciences for water treatment applications to remediate pollutant sequestration in soil. This study aimed to assess th...

  • Article
  • Open Access
10 Citations
3,736 Views
20 Pages

Persistent Organic Pollutants in Austrian Human Breast Milk Collected between 2013 and 2016

  • Christina Hartmann,
  • Andreas-Marius Kaiser,
  • Wolfgang Moche,
  • Stefan Weiss and ,
  • Wolfgang Raffesberg,
  • Sigrid Scharf,
  • Klaudia Graf-Rohrmeister,
  • Margarita Thanhaeuser,
  • Nadja Haiden and
  • Maria Uhl
  • + 5 authors+ 0 author

7 February 2024

Breast milk holds an immense nutritional value as it contains health-promoting substances in a unique, optimal form. Additionally, breast milk’s significance extends to health and environmental protection, as it serves as an indicator of both m...

(This article belongs to the Special Issue Journal of Xenobiotics: Feature Papers)
  • Review
  • Open Access
39 Citations
7,718 Views
20 Pages

Phenolic Compounds of Therapeutic Interest in Neuroprotection

  • José Manuel Nájera-Maldonado,
  • Ricardo Salazar,
  • Patricia Alvarez-Fitz,
  • Macdiel Acevedo-Quiroz and ,
  • Eugenia Flores-Alfaro,
  • Daniel Hernández-Sotelo,
  • Mónica Espinoza-Rojo and
  • Mónica Ramírez
  • + 3 authors+ 0 author

6 February 2024

The number of elderly people is projected to double in the next 50 years worldwide, resulting in an increased prevalence of neurodegenerative diseases. Aging causes changes in brain tissue homeostasis, thus contributing to the development of neurodeg...

(This article belongs to the Section Natural Products/Herbal Medicines)
  • Feature Paper
  • Article
  • Open Access
10 Citations
3,463 Views
13 Pages

Pyriproxyfen Contamination in Daphnia magna: Identifying Early Warning Biomarkers

  • Beatriz Salesa,
  • Javier Torres-Gavilá,
  • María Dolores Ferrando-Rodrigo and
  • Encarnación Sancho

2 February 2024

Pyriproxyfen is an insecticide currently employed in numerous countries for the management of agricultural and indoor pests. Several studies indicate that this insecticide has been detected in multiple rivers, with concentrations reaching as high as...

(This article belongs to the Special Issue Legacy and Emerging Pollutants and Their Effects through the Lens of Environmental Management)
  • Article
  • Open Access
5 Citations
3,262 Views
21 Pages

Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome

  • Mohamed Lahiani,
  • Kuppan Gokulan,
  • Vicki Sutherland,
  • Helen C. Cunny and ,
  • Carl E. Cerniglia and
  • Sangeeta Khare
  • + 1 author+ 0 author

1 February 2024

Triclosan (TCS), a broad-spectrum antibacterial chemical, is detected in human urine, breast milk, amniotic fluid, and feces; however, little is known about its impact on the intestinal microbiome and host mucosal immunity during pregnancy and early...

(This article belongs to the Special Issue Journal of Xenobiotics: Feature Papers)
  • Article
  • Open Access
13 Citations
5,745 Views
17 Pages

Exposure and Health Risks Posed by Potentially Toxic Elements in Soils of Metal Fabrication Workshops in Mbarara City, Uganda

  • Eunice Nuwamanya,
  • Denis Byamugisha,
  • Caroline K. Nakiguli,
  • Christopher Angiro and ,
  • Alice V. Khanakwa,
  • Timothy Omara,
  • Simon Ocakacon,
  • Patrick Onen,
  • Daniel Omoding and
  • Emmanuel Ntambi
  • + 7 authors+ 2 authors

30 January 2024

Metal fabrication workshops (MFWs) are common businesses in Ugandan cities, and especially those producing metallic security gates, window and door frames (burglar-proof), and balcony and staircase rails. The objective of this study was to comparativ...

  • Article
  • Open Access
5 Citations
36,026 Views
10 Pages

12 January 2024

Diagnostic of transsexualism and gender incongruence are terms to describe individuals whose self-identity does not match their sex assignment at birth. A transgender woman is an individual assigned male at birth (AMAB) on the basis of the external o...

(This article belongs to the Special Issue The Role of Endocrine-Disrupting Chemicals in the Human Health)
  • Article
  • Open Access
11 Citations
4,932 Views
12 Pages

12 January 2024

Aims/Objectives: The aim of this cross-sectional observational study was to investigate cytogenetic damage to the buccal mucosa in non-smokers and consumers of traditional combustible tobacco products and non-combustible alternatives. Methods: A tota...

  • Article
  • Open Access
2 Citations
3,060 Views
19 Pages

Silica Nanoparticles Disclose a Detailed Neurodegeneration Profile throughout the Life Span of a Model Organism

  • Annette Limke,
  • Gereon Poschmann,
  • Kai Stühler,
  • Patrick Petzsch and ,
  • Thorsten Wachtmeister and
  • Anna von Mikecz
  • + 1 author+ 0 author

12 January 2024

The incidence of age-related neurodegenerative diseases is rising globally. However, the temporal sequence of neurodegeneration throughout adult life is poorly understood. To identify the starting points and schedule of neurodegenerative events, sero...

  • Review
  • Open Access
15 Citations
6,734 Views
25 Pages

Hazards Associated with the Combined Application of Fungicides and Poultry Litter in Agricultural Areas

  • Dario Corrêa-Junior,
  • Cláudio Ernesto Taveira Parente and
  • Susana Frases

9 January 2024

In recent decades, the poultry farming industry has assumed a pivotal role in meeting the global demand for affordable animal proteins. While poultry farming makes a substantial contribution to food security and nutrition, it also presents environmen...

  • Review
  • Open Access
23 Citations
8,291 Views
14 Pages

Relevance of Carcinogen-Induced Preclinical Cancer Models

  • Raj N. Sewduth and
  • Konstantina Georgelou

5 January 2024

Chemical agents can cause cancer in animals by damaging their DNA, mutating their genes, and modifying their epigenetic signatures. Carcinogen-induced preclinical cancer models are useful for understanding carcinogen-induced human cancers, as they ca...

  • Article
  • Open Access
10 Citations
8,427 Views
17 Pages

Effect of Plant Growth-Promoting Bacteria on Antioxidant Status, Acetolactate Synthase Activity, and Growth of Common Wheat and Canola Exposed to Metsulfuron-Methyl

  • Margarita Bakaeva,
  • Sergey Chetverikov,
  • Sergey Starikov,
  • Aliya Kendjieva and ,
  • Gaisar Khudaygulov and
  • Darya Chetverikova
  • + 1 author+ 0 author

2 January 2024

Metsulfuron-methyl, a widely used herbicide, could cause damage to the sensitive plants in crop-rotation systems at extremely low levels in the soil. The potential of plant growth-promoting bacteria (PGPB) for enhancing the resistance of plants again...

(This article belongs to the Special Issue Plant Biostimulants—a Promising Tool in Organic Farming)
  • Article
  • Open Access
38 Citations
14,552 Views
28 Pages

Microbial Removal of Heavy Metals from Contaminated Environments Using Metal-Resistant Indigenous Strains

  • Cristina Firincă,
  • Lucian-Gabriel Zamfir,
  • Mariana Constantin,
  • Iuliana Răut and ,
  • Luiza Capră,
  • Diana Popa,
  • Maria-Lorena Jinga,
  • Anda Maria Baroi,
  • Radu Claudiu Fierăscu and
  • Tatiana Eugenia Șesan
  • + 10 authors+ 5 authors

29 December 2023

Contamination of soil with heavy metals has become a matter of global importance due to its impact on agriculture, environmental integrity, and therefore human health and safety. Several microbial strains isolated from soil contaminated by long-term...

(This article belongs to the Special Issue Journal of Xenobiotics: Feature Papers)
  • Article
  • Open Access
13 Citations
5,437 Views
20 Pages

An Initial Survey on Occurrence, Fate, and Environmental Risk Assessment of Organophosphate Flame Retardants in Romanian Waterways

  • Iuliana Paun,
  • Florinela Pirvu,
  • Vasile Ion Iancu,
  • Marcela Niculescu and ,
  • Luoana Florentina Pascu and
  • Florentina Laura Chiriac
  • + 1 author+ 0 author

22 December 2023

Organophosphate ester flame retardants (OPFRs) are ubiquitous organic pollutants in the environment and present an important preoccupation due to their potential toxicity to humans and biota. They can be found in various sources, including consumer p...

(This article belongs to the Section Emerging Chemicals)
  • Article
  • Open Access
10 Citations
4,874 Views
16 Pages

The Potential for Genotoxicity, Mutagenicity and Endocrine Disruption in Triclosan and Triclocarban Assessed through a Combination of In Vitro Methods

  • Jan Chrz,
  • Markéta Dvořáková,
  • Kristina Kejlová,
  • Danuše Očadlíková and ,
  • Lada Svobodová,
  • Lukáš Malina,
  • Barbora Hošíková,
  • Dagmar Jírová,
  • Hana Bendová and
  • Hana Kolářová
  • + 5 authors+ 0 author

21 December 2023

Triclosan and Triclocarban, preservatives widely used in cosmetics and other consumer products, underwent evaluation using a battery of new-approach methodologies in vitro (NAMs). Specifically, the Microplate Ames Test (MPF™ Test, Xenometrix, A...

(This article belongs to the Section Emerging Chemicals)
  • Article
  • Open Access
4 Citations
3,393 Views
14 Pages

The Genotoxicity of Organic Extracts from Particulate Emissions Produced by Neat Gasoline (E0) and a Gasoline–Ethanol Blend (E15) in BEAS-2B Cells

  • Helena Libalova,
  • Tana Zavodna,
  • Fatima Elzeinova,
  • Hana Barosova and ,
  • Tereza Cervena,
  • Alena Milcova,
  • Jolana Vankova,
  • Foteini Paradeisi,
  • Michal Vojtisek-Lom and
  • Pavel Rossner
  • + 7 authors+ 2 authors

21 December 2023

Emissions from modern gasoline engines represent an environmental and health risk. In this study, we aimed to compare the toxicity of organic compound mixtures extracted from particulate matter (PM extracts) produced by neat gasoline (E0) and a blend...

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J. Xenobiotics - ISSN 2039-4713