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Hematology Reports, Volume 16, Issue 2

June 2024 - 21 articles

Cover Story: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated decrease in the platelet count and an increased risk of bleeding. The pathogenesis is complex, affecting multiple components of the immune system and causing both peripheral destruction of platelets and impaired central megakaryopoiesis and platelet production in the bone marrow. Here, we intend to contextualize the current knowledge on the pathophysiology, terminology, epidemiology, clinical manifestations, diagnosis, and prognosis of ITP from a historical perspective and the first references to the never-stopping garnering of knowledge about this entity. We highlight the necessity to better understand ITP in order to be able to provide ITP patients with personalized treatment options, improving disease prognosis and reducing the incidence or frequency of refractoriness. View this paper
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Articles (21)

  • Review
  • Open Access
4 Citations
7,917 Views
15 Pages

Neutropenia in Childhood—A Narrative Review and Practical Diagnostic Approach

  • Georgios Katsaras,
  • Silouani Koutsi,
  • Evdokia Psaroulaki,
  • Dimitra Gouni and
  • Pelagia Tsitsani

Neutropenia refers to a decrease in the absolute neutrophil count according to age and race norms and poses a common concern in pediatric practice. Neutrophils serve as host defenders and act crucially in acute inflammation procedures. In this narrat...

  • Case Report
  • Open Access
2,367 Views
8 Pages

Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation

  • Sara Frazzetto,
  • Lara Gullo,
  • Gabriele Sapuppo,
  • Manlio Fazio,
  • Cristina Lo Faro,
  • Giuliana Giunta,
  • Ignazio Caravotta,
  • Elisa Mauro,
  • Marina Silvia Parisi and
  • Anna Maria Triolo
  • + 7 authors

Acute promyelocytic leukemia is a rare form of acute myeloid leukemia in which immature promyelocytes abnormally proliferate in the bone marrow. In most cases, the disease is characterised by the translocation t(15;17) (q24;q21), which causes the for...

  • Review
  • Open Access
4,726 Views
13 Pages

Skin Hypopigmentation in Hematology Disorders

  • Roberto Mazzetto,
  • Paola Miceli,
  • Alvise Sernicola,
  • Jacopo Tartaglia and
  • Mauro Alaibac

Hypopigmentation disorders pose significant diagnostic challenges in dermatology, sometimes reflecting underlying hematological conditions. This review explores the clinical presentations related to hypopigmentation in hematological disorders, focusi...

  • Case Report
  • Open Access
2,677 Views
7 Pages

Blinatumomab in Children with MRD-Positive B-Cell Precursor Acute Lymphoblastic Leukemia: A Report of 11 Cases

  • Yi-Lun Wang,
  • Tsung-Yen Chang,
  • Yu-Chuan Wen,
  • Shu-Ho Yang,
  • Yi-Wen Hsiao,
  • Chia-Chi Chiu,
  • Yu-Chieh Chen,
  • Ruei-Shan Hu,
  • Shih-Hsiang Chen and
  • Tang-Her Jaing
  • + 1 author

Background/Objectives: Relapsed B-cell acute lymphoblastic leukemia (B-ALL) remains an unresolved matter of concern regarding adverse outcomes. This case study aimed to evaluate the effectiveness of blinatumomab, with or without door lymphocyte infus...

  • Article
  • Open Access
2,294 Views
11 Pages

Phase II Trial of Romidepsin as Consolidation Therapy after Gemcitabine, Dexamethasone, and Cisplatin in Elderly Transplant-Ineligible Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma

  • Satoshi Yamasaki,
  • Hiroatsu Iida,
  • Akio Saito,
  • Morio Matsumoto,
  • Yoshiaki Kuroda,
  • Tohru Izumi,
  • Akiko M. Saito,
  • Hiroaki Miyoshi,
  • Koichi Ohshima and
  • Hirokazu Nagai
  • + 1 author

Romidepsin is an important therapeutic option for patients with peripheral T-cell lymphoma (PTCL). However, the timing of romidepsin administration remains controversial. The objective of this study was to characterize the safety and efficacy of romi...

  • Case Report
  • Open Access
2,167 Views
5 Pages

Morphological Clues of Acute Monocytic Leukemia in COVID-19-Induced Transient Leukoerythroblastic Reaction with Monocytosis

  • Ingrid S. Tam,
  • Mohamed Elemary,
  • John DeCoteau,
  • Anna Porwit and
  • Emina E. Torlakovic

Viral infections, including those caused by COVID-19, can produce striking morphologic changes in peripheral blood. Distinguishing between reactive changes and abnormal morphology of monocytes remains particularly difficult, with low consensus rates...

  • Review
  • Open Access
2 Citations
7,809 Views
14 Pages

Most patients with diffuse large B-cell lymphoma (DLBCL) are >65 years of age, with the number of patients expected to increase in the coming years. A comprehensive geriatric assessment that carefully evaluates fitness status and comorbidities is...

  • Case Report
  • Open Access
2,354 Views
9 Pages

EBV-Positive Nodal T- and NK-Cell Lymphoma Mimicking Anaplastic Large Cell Lymphoma: A Case Report

  • Brooj Abro,
  • Pamela Allen,
  • Saja Asakrah,
  • Kyle Bradley and
  • Linsheng Zhang

EBV-positive nodal T- and NK-cell lymphoma (EBV+ NT/NKCL) is a recently recognized entity in the 5th edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Notably, CD30 positivity is frequently observed in (EBV+ NT/NKCL),...

  • Case Report
  • Open Access
1 Citations
1,689 Views
9 Pages

Complications of Brentuximab Therapy in Patients with Hodgkin’s Lymphoma and Concurrent Autoimmune Pathology—A Case Series

  • Oana Diana Preda,
  • Sorina Bădeliță,
  • Iulia Ursuleac,
  • Ruxandra Maria Irimia,
  • Sonia Balanica,
  • Monica Cojocaru,
  • Cristina Cotruta,
  • Camelia Dobrea and
  • Daniel Coriu

Background: Brentuximab Vedotin (BV) has revolutionized the treatment landscape for Hodgkin’s lymphoma, yet its effects on pre-existing autoimmune disorders remain elusive. Methods: Here, we present four cases of patients with concurrent autoim...

  • Case Report
  • Open Access
2 Citations
2,189 Views
4 Pages

Anti-PF4 ELISA-Negative, SRA-Positive Heparin-Induced Thrombocytopenia

  • Abraham Attah,
  • Chelsea Peterson,
  • Max Jacobs,
  • Rama Bhagavatula,
  • Deep Shah,
  • Robert Kaplan and
  • Yazan Samhouri

Heparin products are frequently used in the inpatient setting to prevent and treat venous thromboembolism, but they simultaneously put patients at risk of developing heparin-induced thrombocytopenia (HIT). The 4Ts score determines the pretest probabi...

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Hematol. Rep. - ISSN 2038-8330Creative Common CC BY license