2026 December - 8 articles
Background: This study aimed to evaluate the association of the CYP11B2 C(-344)T polymorphism with cardiorenal phenotypes and atherosclerosis in patients with DM. Methods: A total of 269 patients with DM (180 with type 2 and 89 with type 1 diabetes)...
Somatic hematopoietic mutations, particularly clonal hematopoiesis of indeterminate potential (CHIP), represent an emerging link between aging, inflammation and cardiovascular disease beyond their established relevance in hematology. This narrative r...
Non-dilated left ventricular cardiomyopathy (NDLVC) presents a unique clinical paradox: patients with nearly identical phenotypes can face radically different clinical outcomes. NDLVC has been recently recognized as a distinct dynamic phenotype withi...
Sudden cardiac death (SCD) accounts for a substantial share of deaths in young individuals. Despite postmortem pathological, toxicological, and forensic examination and molecular autopsy, many cases remain unexplained, highlighting the need for compl...
Background: Contemporary series report declining sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM), but whether this reflects fewer arrhythmic events or a greater proportion of deaths successfully prevented is unclear. We examined the p...
The 2025 Editor’s Choice papers [...]
Mosaic loss of the Y chromosome (mLOY) is a common karyotype alteration. The accumulation of LOY cells leads to genetic mosaicism and affects the development of pathological conditions in elderly men. Emerging data suggest that this phenomenon might...
Background: Hypertrophic cardiomyopathy (HCM) exhibits clinical heterogeneity and age-related penetrance, yet its molecular basis across adulthood remains incompletely understood. This study aimed to characterize age-dependent transcriptomic signatur...
