Genetic Insights into Sudden Cardiac Death: From Risk Stratification to Precision Prevention

Dear Colleagues,

Sudden cardiac death (SCD) remains a major public health concern and a devastating event, particularly when it affects young individuals with no prior symptoms. Inherited cardiac diseases, such as cardiomyopathies and channelopathies, are increasingly recognized as key contributors to SCD, especially in younger populations. The rapid evolution of genomic technologies and our growing understanding of gene–disease associations are opening new possibilities for early detection, risk stratification, and targeted interventions.

This Special Issue aims to capture the latest advances in the genetic and molecular underpinnings of SCD, bridging basic science and clinical practice. We invite original research, systematic reviews, and illustrative case reports on topics including, but not limited to, the following:

• Discovery of novel genes and variants associated with SCD;
• Genotype–phenotype correlations in inherited cardiac disorders;
• Risk stratification algorithms integrating clinical, imaging, and genetic data;
• Role of whole exome/genome sequencing and polygenic risk scores;
• Sudden death in rare diseases and systemic conditions with cardiac involvement;
• Forensic and ethical aspects of post mortem genetic testing ("molecular autopsy");
• Impact of family screening and genetic counseling in prevention strategies.

This Special Issue will provide a comprehensive platform for sharing insights into how genetic knowledge is transforming the prevention and management of SCD, with the ultimate goal of improving outcomes through more personalized and anticipatory approaches to care.

Dr. Giuseppe Limongelli
Dr. Lia Crotti
Dr. Emanuele Bobbio
Dr. Saskia Nanette Van Der Crabben
Guest Editors

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