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Pharmaceutics, Volume 2, Issue 1

March 2010 - 5 articles

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Articles (5)

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Article

5 Citations

11,765 Views

17 Pages

The Effects of Pregnenolone 16α-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat

Simon Lowes,
Iain S. Haslam,
Britt-Marie Fihn,
Constanze Hilgendorf,
Johan E. Karlsson,
Nicholas L. Simmons and
Anna-Lena Ungell

Pharmaceutics2010, 2(1), 61-77;https://doi.org/10.3390/pharmaceutics2010061

15 March 2010

The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed. After intravenous or oral digoxin dosing the arterial and hepatic portal vei...

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Article

7 Citations

7,541 Views

11 Pages

Ingredient Consistency of Commercially Available Polyphenol and Tocopherol Nutraceuticals

Connie M. Remsberg,
Renee L. Good and
Neal M. Davies

Pharmaceutics2010, 2(1), 50-60;https://doi.org/10.3390/pharmaceutics2010050

8 March 2010

Label claims of vitamin E succinate and polyphenolic nutraceuticals are assessed. A validated HPLC method was utilized to assess vitamin E succinate products. Three novel LC/MS methods were used to assess the polyphenols, pterostilbene, phloretin, an...

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Article

42 Citations

12,302 Views

20 Pages

Quantification of Process Induced Disorder in Milled Samples Using Different Analytical Techniques

Ulrike Zimper,
Jaakko Aaltonen,
Cushla M. McGoverin,
Keith C. Gordon,
Karen Krauel-Goellner and
Thomas Rades

Pharmaceutics2010, 2(1), 30-49;https://doi.org/10.3390/pharmaceutics2010030

16 February 2010

The aim of this study was to compare three different analytical methods to detect and quantify the amount of crystalline disorder/ amorphousness in two milled model drugs. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and R...

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Article

32 Citations

9,241 Views

12 Pages

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS

Irene Zagol-Ikapitte,
Elena Matafonova,
Venkataraman Amarnath,
Christopher L. Bodine,
Olivier Boutaud,
Rommel G. Tirona,
John A. Oates,
L. Jackson Roberts II and
Sean S. Davies

Pharmaceutics2010, 2(1), 18-29;https://doi.org/10.3390/pharmaceutics2010018

1 February 2010

Levels of reactive γ-ketoaldehydes derived from arachidonate increase in diseases associated with inflammation and oxidative injury. To assess the biological importance of these γ-ketoaldehydes, we previously identified salicylamine as an effective γ...

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Article

20 Citations

9,591 Views

17 Pages

Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid Combination

Farhan AlHusban,
Amr M. ElShaer,
Jiteen H. Kansara,
Alan M. Smith,
Liam M. Grover,
Yvonne Perrie and
Afzal R. Mohammed

Pharmaceutics2010, 2(1), 1-17;https://doi.org/10.3390/pharmaceutics2010001

4 January 2010

Lyophilised orally disintegrating tablets (ODTs) have achieved a great success in overcoming dysphagia associated with conventional solid dosage forms. However, the extensive use of saccharides within the formulation limits their use in treatment of...

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