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Pharmaceutics, Volume 17, Issue 1

January 2025 - 138 articles

Cover Story: This study explores the synergistic effects of mechanical high-intensity focused ultrasound (M-HIFU) and dendritic cell (DC) vaccines in targeting OLFM4-expressing tumors. OLFM4, associated with cancer stem cells (CSCs), promotes immune evasion and tumor progression. M-HIFU induces immunogenic cell death, releasing tumor antigens and enhancing immune responses, while DC vaccines loaded with OLFM4 amplify anti-tumor immunity. Combination therapy involving both has shown significant tumor suppression, reduced metastasis, and improved immune memory. Further, intratumoral DC administration alongside M-HIFU was particularly effective. This approach highlights a promising strategy for enhancing cancer immunotherapy through tumor microenvironment modulation. View this paper
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Articles (138)

  • Article
  • Open Access
1 Citations
3,499 Views
23 Pages

Biotechnological Phytocomplex of Zanthoxylum piperitum (L.) DC. Enhances Collagen Biosynthesis In Vitro and Improves Skin Elasticity In Vivo

  • Giovanna Rigillo,
  • Giovanna Pressi,
  • Oriana Bertaiola,
  • Chiara Guarnerio,
  • Matilde Merlin,
  • Roberto Zambonin,
  • Stefano Pandolfo,
  • Angela Golosio,
  • Francesca Masin and
  • Fabio Tascedda
  • + 2 authors

Background: Zanthoxylum piperitum (L.) DC., commonly known as Japanese pepper, is a deciduous shrub native to East Asia. Its berries are widely used as a spice, known for imparting a distinctive, tingly numbing sensation. Biologically, Z. piperi...

  • Review
  • Open Access
5 Citations
2,343 Views
32 Pages

Magnetic nanoparticles (MNPs) are advanced materials that combine the unique properties of magnetic materials and nanoscale dimensions, enabling a wide range of applications in biomedicine, environmental science, and information technology. This revi...

  • Review
  • Open Access
29 Citations
6,550 Views
61 Pages

Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques

  • Shery Jacob,
  • Fathima Sheik Kather,
  • Sai H. S. Boddu,
  • Mahesh Attimarad and
  • Anroop B. Nair

Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recen...

  • Article
  • Open Access
2 Citations
3,351 Views
14 Pages

Monitoring M-Protein, Therapeutic Antibodies, and Polyclonal Antibodies in a Multiparametric Mass Spectrometry Assay Provides Insight into Therapy Response Kinetics in Patients with Multiple Myeloma

  • Charissa Wijnands,
  • Peter G. A. Karel,
  • Jolein Gloerich,
  • Gad Armony,
  • Anastasia Tzasta,
  • Corrie M. de Kat Angelino,
  • Luciano Di Stefano,
  • Vincent Bonifay,
  • Theo M. Luider and
  • Martijn M. VanDuijn
  • + 8 authors

Background/Objectives: Multiple Myeloma (MM) is a hematologic malignancy caused by clonally expanded plasma cells that produce a monoclonal immunoglobulin (M-protein), a personalized biomarker. Recently, we developed an ultra-sensitive mass spectrome...

  • Review
  • Open Access
26 Citations
5,762 Views
30 Pages

Resveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, in particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxan...

  • Article
  • Open Access
3,097 Views
20 Pages

Alginate Hydrogel Beads with a Leakproof Gold Shell for Ultrasound-Triggered Release

  • Marcus Flowers,
  • Alex Paulsen,
  • Claire R. W. Kaiser,
  • Adam B. Tuma,
  • Hubert H. Lim,
  • Brenda M. Ogle and
  • Chun Wang

Background/Objectives: Focused ultrasound has advantages as an external stimulus for drug delivery as it is non-invasive, has high precision and can penetrate deep into tissues. Here, we report a gold-plated alginate (ALG) hydrogel system that retain...

  • Article
  • Open Access
5 Citations
2,481 Views
21 Pages

Chitosan Nanoparticles for Enhanced Immune Response and Delivery of Multi-Epitope Helicobacter pylori Vaccines in a BALB/c Mouse Model

  • Rita Amaral,
  • Tomás Concha,
  • Jorge Vítor,
  • António J. Almeida,
  • Cecília Calado and
  • Lídia M. Gonçalves

Background/Objectives: Helicobacter pylori is the leading cause of chronic gastritis, peptic ulcer, gastric adenocarcinoma, and mucosal-associated lymphoma. Due to the emerging problems with antibiotic treatment against H. pylori in clinical practice...

  • Article
  • Open Access
2 Citations
2,183 Views
21 Pages

Background/Objectives: Non-viral vectors have gained recognition for their ability to enhance the safety of gene delivery processes. Among these, polyethyleneimine (PEI) stands out as the most widely utilized cationic polymer due to its accessibility...

  • Article
  • Open Access
3 Citations
1,460 Views
20 Pages

Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations

  • Diana-Andreea Blaj,
  • Catalina A. Peptu,
  • Mihaela Balan-Porcarasu,
  • Cristian Peptu,
  • Cristina Gabriela Tuchilus and
  • Lacramioara Ochiuz

Background: Magnolol (MG) and honokiol (HK) are bioactive compounds extracted from Magnolia obovata and Magnolia Officinalis trees with significant pharmacological properties, including antioxidant and antibacterial activity. However, their poor wate...

  • Article
  • Open Access
5 Citations
1,799 Views
12 Pages

Background/Objectives: This study investigates for the first time the use of the prilling technique in combination with solvent evaporation to produce nano- and submicrometric PLGA particles to deliver properly an active pharmaceutical ingredient. Cu...

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Pharmaceutics - ISSN 1999-4923