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Pharmaceutics, Volume 15, Issue 8

August 2023 - 158 articles

Cover Story: Lipid nano-systems stand out as one of the most attractive vehicles that can fuse with endothelial cells and transport active compounds. Despite numerous studies conducted on these carriers, their safety and efficacy still cannot be guaranteed, taking into consideration all aspects from their physical–chemical and biopharmaceutical properties to all the biological characteristics of living organisms. Thus, the question arises of weather and how the features of these systems will affect their fate in different cell lines? This research includes comparative studies of the behavior of liposomes and nanostructured lipid-carriers in a series of well-structured in vitro tests that could assess their interactions with the hCMEC/D3 and SH-SY5Y cell lines as an in vitro model of the blood–brain barrier and neuronal function, respectively. View this paper
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Articles (158)

  • Review
  • Open Access
21 Citations
4,220 Views
22 Pages

Exploring the Antioxidant Potential of Gellan and Guar Gums in Wound Healing

  • Gianina Dodi,
  • Rosina E. Sabau,
  • Bianca E.-B. Crețu and
  • Ioannis Gardikiotis

It is acknowledged that the presence of antioxidants boosts the wound-healing process. Many biopolymers have been explored over the years for their antioxidant potential in wound healing, but limited research has been performed on gum structures and...

  • Review
  • Open Access
16 Citations
6,864 Views
18 Pages

Chronic inflammatory respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, present ongoing challenges in terms of effective treatment and management. These diseases are characterized by persistent in...

  • Review
  • Open Access
7 Citations
3,805 Views
17 Pages

Kidney disease has become a serious public health problem throughout the world, and its treatment and management constitute a huge global economic burden. Currently, the main clinical treatments are not sufficient to cure kidney diseases. During its...

  • Article
  • Open Access
8 Citations
3,732 Views
21 Pages

Breast Milk Mesenchymal Stem Cells and/or Derived Exosomes Mitigated Adenine-Induced Nephropathy via Modulating Renal Autophagy and Fibrotic Signaling Pathways and Their Epigenetic Regulations

  • Tarek Khamis,
  • Amira Ebrahim Alsemeh,
  • Asma Alanazi,
  • Asmaa Monir Eltaweel,
  • Heba M. Abdel-Ghany,
  • Doaa M. Hendawy,
  • Adel Abdelkhalek,
  • Mahmoud A. Said,
  • Heba H. Awad and
  • Basma Hamed Ibrahim
  • + 4 authors

Chronic kidney disease (CKD), a global health concern, is highly prevalent among adults. Presently, there are limited therapeutic options to restore kidney function. This study aimed to investigate the therapeutic potential of breast milk mesenchymal...

  • Article
  • Open Access
9 Citations
4,945 Views
16 Pages

The Influence of Wet Granulation Parameters on the Compaction Behavior and Tablet Strength of a Hydralazine Powder Mixture

  • Oliver Macho,
  • Ľudmila Gabrišová,
  • Adam Guštafík,
  • Kristian Jezso,
  • Martin Juriga,
  • Juraj Kabát and
  • Jaroslav Blaško

The aim of this paper was to describe the influence of high-shear wet granulation process parameters on tablet tensile strength and compaction behavior of a powder mixture and granules containing hydralazine. The hydralazine powder mixture and eight...

  • Article
  • Open Access
5 Citations
2,886 Views
20 Pages

The Influence of the Intergranular Superdisintegrant Performance on New Drotaverine Orodispersible Tablet Formulations

  • Robert-Alexandru Vlad,
  • Cezara Pintea,
  • Diana-Andreea Chirteș,
  • Paula Antonoaea,
  • Emöke Margit Rédai,
  • Nicoleta Todoran,
  • Magdalena Bîrsan and
  • Adriana Ciurba

The main objective of this study consists in establishing the influence of the intergranular superdisintegrant on the specific properties of drotaverine hydrochloride fast-dissolving granules (DROT-FDGs) and orodispersible tablets (DROT-ODTs). The or...

  • Article
  • Open Access
1 Citations
2,295 Views
16 Pages

Injectable polymer microparticles with the ability to carry and release pharmacologically active agents are attracting more and more interest. This study is focused on the chemical synthesis, characterization, and preliminary exploration of the utili...

  • Article
  • Open Access
6 Citations
2,713 Views
20 Pages

Enhanced Cartilage and Subchondral Bone Repair Using Carbon Nanotube-Doped Peptide Hydrogel–Polycaprolactone Composite Scaffolds

  • Jiayi Lv,
  • Yilun Wu,
  • Zhicheng Cao,
  • Xu Liu,
  • Yuzhi Sun,
  • Po Zhang,
  • Xin Zhang,
  • Kexin Tang,
  • Min Cheng and
  • Qingqiang Yao
  • + 1 author

A carbon nanotube-doped octapeptide self-assembled hydrogel (FEK/C) and a hydrogel-based polycaprolactone PCL composite scaffold (FEK/C3-S) were developed for cartilage and subchondral bone repair. The composite scaffold demonstrated modulated micros...

  • Article
  • Open Access
6 Citations
2,418 Views
15 Pages

Molecular Imaging Investigations of Polymer-Coated Cerium Oxide Nanoparticles as a Radioprotective Therapeutic Candidate

  • Philip Reed McDonagh,
  • Sundaresan Gobalakrishnan,
  • Christopher Rabender,
  • Vimalan Vijayaragavan and
  • Jamal Zweit

Cerium oxide nanoparticles (CONPs) have a unique surface redox chemistry that appears to selectively protect normal tissues from radiation induced damage. Our prior research exploring the biocompatibility of polymer-coated CONPs found further study o...

  • Article
  • Open Access
5 Citations
2,479 Views
11 Pages

Antiemetic Drugs Compatibility Evaluation with Paediatric Parenteral Nutrition Admixtures

  • Szymon Tomczak,
  • Maciej Chmielewski,
  • Jagoda Szkudlarek and
  • Anna Jelińska

Chemotherapy-induced nausea and vomiting are defined as the most common of side effects of treatment and, at the same time, are very difficult to accept for patients’, frequently causing changes in the therapy regimen, significantly reducing it...

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Pharmaceutics - ISSN 1999-4923