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Pharmaceutics, Volume 15, Issue 6

June 2023 - 213 articles

Cover Story: Localized photodynamic therapy (PDT) is a promising approach to treating breast cancer since it triggers immunity against recurrence and metastasis distant from the treated area. Despite that, the widespread application of PDT is limited by a photosensitizer's (PS) tendency to aggregate and lack of selectivity for cancer cells. In this work, we report a nanotechnological biomimetic formulation for transporting the PS meso-tetraphenylchlorin disulfonate (TPCS2a). Poly(lactic-co-glycolic) acid nanoparticles efficiently loaded TPCS2a and were coated with mesenchymal stem cell-derived plasma membranes to avoid premature clearance by the mononuclear phagocytes system and favor tumor accumulation. Encapsulation of TPCS2a into nanoparticles prevents its aggregation, facilitating the administration while maintaining therapeutic efficacy. View this paper
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Articles (213)

  • Article
  • Open Access
7 Citations
2,881 Views
20 Pages

Propolis as a Cariostatic Agent in Lozenges and Impact of Storage Conditions on the Stability of Propolis

  • Anna Kurek-Górecka,
  • Paweł Ramos,
  • Małgorzata Kłósek,
  • Elżbieta Bobela,
  • Zenon P. Czuba,
  • Radosław Balwierz and
  • Paweł Olczyk

Propolis is known as a source of compounds with strong antibacterial activity. Due to the antibacterial effect against streptococci of the oral cavity, it seems to be a useful agent in decreasing the accumulation of dental plaque. It is rich in polyp...

  • Correction
  • Open Access
1 Citations
1,424 Views
2 Pages

Correction: Kazimir et al. Metallodrugs against Breast Cancer: Combining the Tamoxifen Vector with Platinum(II) and Palladium(II) Complexes. Pharmaceutics 2023, 15, 682

  • Aleksandr Kazimir,
  • Benedikt Schwarze,
  • Peter Lönnecke,
  • Sanja Jelača,
  • Sanja Mijatović,
  • Danijela Maksimović-Ivanić and
  • Evamarie Hey-Hawkins

In the original publication [...]

  • Review
  • Open Access
24 Citations
7,747 Views
17 Pages

Shining a Light on Prostate Cancer: Photodynamic Therapy and Combination Approaches

  • Hicham Wahnou,
  • Ibtissam Youlyouz-Marfak,
  • Bertrand Liagre,
  • Vincent Sol,
  • Mounia Oudghiri,
  • Raphaël Emmanuel Duval and
  • Youness Limami

Prostate cancer is a major health concern worldwide, and current treatments, such as surgery, radiation therapy, and chemotherapy, are associated with significant side effects and limitations. Photodynamic therapy (PDT) is a promising alternative tha...

  • Article
  • Open Access
10 Citations
4,579 Views
15 Pages

Preparation and In Vitro Characterization of Microneedles Containing Inclusion Complexes Loaded with Progesterone

  • Hongji He,
  • Zhaozhi Wang,
  • Kadireya Aikelamu,
  • Jingya Bai,
  • Qi Shen,
  • Xiaoli Gao and
  • Mei Wang

Objective: In order to improve patient compliance and the ease of use during progesterone application, and to increase the clinical application of progesterone, progesterone was made into a microneedle. Methods: Progesterone complexes were prepared u...

  • Review
  • Open Access
9 Citations
3,338 Views
15 Pages

Infection persists as one of the leading global causes of morbidity and mortality, with particular burden at the extremes of age and in populations who are immunocompromised or suffer chronic co-morbid diseases. By focusing discovery and innovation e...

  • Review
  • Open Access
5 Citations
4,904 Views
12 Pages

Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder caused by mutations in the survival of motor neuron 1 (SMN1) gene, which leads to a reduced level in the SMN protein within cells. Patients with SMA suffer from a loss of alpha mot...

  • Article
  • Open Access
15 Citations
2,977 Views
20 Pages

Evaluation of the In Vitro Antimicrobial Efficacy against Staphylococcus aureus and epidermidis of a Novel 3D-Printed Degradable Drug Delivery System Based on Polycaprolactone/Chitosan/Vancomycin—Preclinical Study

  • Iván López-González,
  • Ana Belén Hernández-Heredia,
  • María Isabel Rodríguez-López,
  • David Auñón-Calles,
  • Mohamed Boudifa,
  • José Antonio Gabaldón and
  • Luis Meseguer-Olmo

Acute and chronic bone infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA), remains a major complication and therapeutic challenge. It is documented that local administration of vancomycin offers better results t...

  • Feature Paper
  • Article
  • Open Access
5 Citations
2,678 Views
19 Pages

The generation and accumulation of an electrostatic charge from handling pharmaceutical powders is a well-known phenomenon, given the insulating nature of most APIs (Active Pharmaceutical Ingredients) and excipients. In capsule-based DPIs (Dry Powder...

  • Feature Paper
  • Review
  • Open Access
12 Citations
4,841 Views
18 Pages

Recent developments aim to extend the cytotoxic effect and therapeutic window of mAbs by constructing antibody–drug conjugates (ADCs), in which the targeting moiety is the mAb that is linked to a highly toxic drug. According to a report from mi...

  • Review
  • Open Access
7 Citations
5,427 Views
13 Pages

Immune-Modulating Lipid Nanomaterials for the Delivery of Biopharmaceuticals

  • Songhee Kim,
  • Boseung Choi,
  • Yoojin Kim and
  • Gayong Shim

In recent years, with the approval of preventative vaccines for pandemics, lipid nanoparticles have become a prominent RNA delivery vehicle. The lack of long-lasting effects of non-viral vectors is an advantage for infectious disease vaccines. With t...

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Pharmaceutics - ISSN 1999-4923