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Pharmaceutics, Volume 12, Issue 5

May 2020 - 90 articles

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Cover Story: The development of next-generation nanomedicines is being greatly impacted by the broadening of the therapeutic possibilities of nanotechnology, allowing new therapeutic targets to be reached and the overall therapeutic profile to be improved. This review covers the new strategies and possibilities for delivery of therapeutic biomolecules: peptides, proteins, nucleic acids and glycans with mesoporous silica-based nanosystems. View this paper

Articles (90)

  • Article
  • Open Access
44 Citations
6,882 Views
23 Pages

Systemic toxicity and severe side effects are commonly associated with anticancer chemotherapies. New strategies based on enhanced drug selectivity and targeted delivery to cancer cells while leaving healthy tissue undamaged can reduce the global pat...

  • Article
  • Open Access
11 Citations
4,354 Views
23 Pages

Cell Theranostics on Mesoporous Silicon Substrates

  • Maria Laura Coluccio,
  • Valentina Onesto,
  • Giovanni Marinaro,
  • Mauro Dell’Apa,
  • Stefania De Vitis,
  • Alessandra Imbrogno,
  • Luca Tirinato,
  • Gerardo Perozziello,
  • Enzo Di Fabrizio and
  • Patrizio Candeloro
  • + 2 authors

The adhesion, proliferation, and migration of cells over nanomaterials is regulated by a cascade of biochemical signals that originate at the interface of a cell with a substrate and propagate through the cytoplasm to the nucleus. The topography of t...

  • Article
  • Open Access
13 Citations
4,554 Views
17 Pages

Metallo-Liposomes of Ruthenium Used as Promising Vectors of Genetic Material

  • José Antonio Lebrón,
  • Francisco José Ostos,
  • Manuel López-López,
  • María Luisa Moyá,
  • Carlos Sales,
  • Encarnación García,
  • Clara Beatriz García-Calderón,
  • Margarita García-Calderón,
  • María José Peña-Gómez and
  • Iván V. Rosado
  • + 3 authors

Gene therapy is a therapeutic process consisting of the transport of genetic material into cells. The design and preparation of novel carriers to transport DNA is an important research line in the medical field. Hybrid compounds such as metallo-lipos...

  • Article
  • Open Access
27 Citations
4,806 Views
22 Pages

In Vitro Antigenotoxic, Antihelminthic and Antioxidant Potentials Based on the Extracted Metabolites from Lichen, Candelariella vitellina

  • Islam El-Garawani,
  • Mahmoud Emam,
  • Waill Elkhateeb,
  • Hesham El-Seedi,
  • Shaden Khalifa,
  • Salwa Oshiba,
  • Shaimaa Abou-Ghanima and
  • Ghoson Daba

Lichens have recently received great attention due to their pharmacological potentials. The antigenotoxic potential of C. vitellina extract (25 and 50 µg/mL) was assessed in normal human peripheral blood lymphocytes (HPBL) against Mitomycin C (...

  • Communication
  • Open Access
11 Citations
3,481 Views
12 Pages

Melanoma is one of the most serious skin cancers. The incidence of this malignant skin lesion is continuing to increase worldwide. Melanoma is resistant to chemotherapeutic drugs and highly metastatic. Surgical resection can only be used to treat mel...

  • Article
  • Open Access
11 Citations
3,703 Views
18 Pages

Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model

  • Yuan-Yun Tseng,
  • Tao-Chieh Yang,
  • Shu-Mei Chen,
  • Shun-Tai Yang,
  • Ya-Ling Tang and
  • Shih-Jung Liu

Malignant glioma (MG) is extremely aggressive and highly resistant to chemotherapeutic agents. Using electrospraying, the potent chemotherapeutic agent 7-ethyl-10-hydroxycamptothecia (SN-38) was embedded into 50:50 biodegradable poly[(d,l)-lactide-co...

  • Article
  • Open Access
14 Citations
5,033 Views
20 Pages

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I2-Imidazoline Receptor Ligand MCR5

  • Foteini Vasilopoulou,
  • Andrea Bagan,
  • Sergio Rodriguez-Arevalo,
  • Carmen Escolano,
  • Christian Griñán-Ferré and
  • Mercè Pallàs

Behavioural and psychological symptoms of dementia (BPSD), including fear-anxiety- and depressive-like behaviour, are present in Alzheimer’s disease (AD), together with memory decline. I2-imidazoline receptors (I2-IRs) have been associated with...

  • Article
  • Open Access
57 Citations
5,578 Views
27 Pages

Optimization of Curcumin Nanocrystals as Promising Strategy for Nose-to-Brain Delivery Application

  • Angela Bonaccorso,
  • Maria Rosa Gigliobianco,
  • Rosalia Pellitteri,
  • Debora Santonocito,
  • Claudia Carbone,
  • Piera Di Martino,
  • Giovanni Puglisi and
  • Teresa Musumeci

Intranasal (IN) drug delivery is recognized to be an innovative strategy to deliver drugs to the Central Nervous System. One of the main limitations of IN dosing is the low volume of drug that can be administered. Accordingly, two requirements are ne...

  • Article
  • Open Access
11 Citations
3,199 Views
23 Pages

Stepwise Glucoheptoamidation of Poly(Amidoamine) Dendrimer G3 to Tune Physicochemical Properties of the Potential Drug Carrier: In Vitro Tests for Cytisine Conjugates

  • Anna Czerniecka-Kubicka,
  • Piotr Tutka,
  • Marek Pyda,
  • Małgorzata Walczak,
  • Łukasz Uram,
  • Maria Misiorek,
  • Ewelina Chmiel and
  • Stanisław Wołowiec

Third-generation poly(amidoamine) dendrimer (PAMAM) was modified by stepwise primary amine group amidation with d-glucoheptono-1,4-lactone. The physicochemical properties of the conjugates—size, ζ potential in lysosomal pH 5 and in neutral...

  • Review
  • Open Access
98 Citations
7,251 Views
17 Pages

Therapeutic Use of Mesenchymal Stem Cell-Derived Exosomes: From Basic Science to Clinics

  • Carl Randall Harrell,
  • Nemanja Jovicic,
  • Valentin Djonov and
  • Vladislav Volarevic

Mesenchymal stem cells (MSC) are, due to their immunosuppressive and regenerative properties, used as new therapeutic agents in cell-based therapy of inflammatory and degenerative diseases. A large number of experimental and clinical studies revealed...

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