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Open AccessArticle

Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model

1
Division of Neurosurgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei 11031, Taiwan
2
Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
3
Department of Neurosurgery, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
4
Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan
5
Department of Mechanical Engineering, Chang Gung University, Taoyuan 33302, Taiwan
6
Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkou, Taoyuan 33305, Taiwan
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(5), 479; https://doi.org/10.3390/pharmaceutics12050479
Received: 15 April 2020 / Revised: 20 May 2020 / Accepted: 22 May 2020 / Published: 24 May 2020
(This article belongs to the Special Issue Biocompatible Materials in Drug Delivery System in Oncology)
Malignant glioma (MG) is extremely aggressive and highly resistant to chemotherapeutic agents. Using electrospraying, the potent chemotherapeutic agent 7-ethyl-10-hydroxycamptothecia (SN-38) was embedded into 50:50 biodegradable poly[(d,l)-lactide-co-glycolide] (PLGA) microparticles (SMPs). The SMPs were stereotactically injected into the brain parenchyma of healthy rats and intratumorally injected into F98 glioma-bearing rats for estimating the pharmacodynamics and therapeutic efficacy. SN-38 was rapidly released after injection and its local (brain tissue) concentration remained much higher than that in the blood for more than 8 weeks. Glioma-bearing rats were divided into three groups—group A (n = 13; stereotactically injected pure PLGA microparticles), group B (n = 12; stereotactically injected Gliadel wafer and oral temozolomide), and group C (n = 13; stereotactic and intratumoral introduction of SMPs). The SMPs exhibited significant therapeutic efficacy, with prolonged survival, retarded tumor growth, and attenuated malignancy. The experimental results demonstrated that SMPs provide an effective and potential strategy for the treatment of MG. View Full-Text
Keywords: malignant glioma (MG); 7-ethyl-10-hydroxycamptothecia (SN-38); irinotecan (CPT-11); poly(lactide-co-glycolide) (PLGA); intratumoral drug delivery malignant glioma (MG); 7-ethyl-10-hydroxycamptothecia (SN-38); irinotecan (CPT-11); poly(lactide-co-glycolide) (PLGA); intratumoral drug delivery
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MDPI and ACS Style

Tseng, Y.-Y.; Yang, T.-C.; Chen, S.-M.; Yang, S.-T.; Tang, Y.-L.; Liu, S.-J. Injectable SN-38-embedded Polymeric Microparticles Promote Antitumor Efficacy against Malignant Glioma in an Animal Model. Pharmaceutics 2020, 12, 479.

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