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Article

Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes

1
Department of Chemistry, Fribourg University, Chemin du Musée 9, 1700 Fribourg, Switzerland
2
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(5), 480; https://doi.org/10.3390/pharmaceutics12050480
Received: 17 April 2020 / Revised: 19 May 2020 / Accepted: 20 May 2020 / Published: 25 May 2020
(This article belongs to the Special Issue Hybrid Multifunctional Drug Delivery Systems)
Systemic toxicity and severe side effects are commonly associated with anticancer chemotherapies. New strategies based on enhanced drug selectivity and targeted delivery to cancer cells while leaving healthy tissue undamaged can reduce the global patient burden. Herein, we report the design, synthesis and characterization of a bio-inspired hybrid multifunctional drug delivery system based on diatom microalgae. The microalgae’s surface was chemically functionalized with hybrid vitamin B12-photoactivatable molecules and the materials further loaded with highly active rhenium(I) tricarbonyl anticancer complexes. The constructs showed enhanced adherence to colorectal cancer (CRC) cells and slow release of the chemotherapeutic drugs. The overall toxicity of the hybrid multifunctional drug delivery system was further enhanced by photoactivation of the microalgae surface. Depending on the construct and anticancer drug, a 2-fold increase in the cytotoxic efficacy of the drug was observed upon light irradiation. The use of this targeted drug delivery strategy, together with selective spatial–temporal light activation, may lead to lower effective concentration of anticancer drugs, thereby reducing medication doses, possible side effects and overall burden for the patient. View Full-Text
Keywords: diatoms; drug delivery system; HCT-116; porphyrin; vitamin B12; carbon monoxide releasing molecule; rhenium; cancer diatoms; drug delivery system; HCT-116; porphyrin; vitamin B12; carbon monoxide releasing molecule; rhenium; cancer
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MDPI and ACS Style

Delasoie, J.; Schiel, P.; Vojnovic, S.; Nikodinovic-Runic, J.; Zobi, F. Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes. Pharmaceutics 2020, 12, 480. https://doi.org/10.3390/pharmaceutics12050480

AMA Style

Delasoie J, Schiel P, Vojnovic S, Nikodinovic-Runic J, Zobi F. Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes. Pharmaceutics. 2020; 12(5):480. https://doi.org/10.3390/pharmaceutics12050480

Chicago/Turabian Style

Delasoie, Joachim, Philippe Schiel, Sandra Vojnovic, Jasmina Nikodinovic-Runic, and Fabio Zobi. 2020. "Photoactivatable Surface-Functionalized Diatom Microalgae for Colorectal Cancer Targeted Delivery and Enhanced Cytotoxicity of Anticancer Complexes" Pharmaceutics 12, no. 5: 480. https://doi.org/10.3390/pharmaceutics12050480

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