You are currently viewing a new version of our website. To view the old version click .

Viruses, Volume 17, Issue 7

July 2025 - 153 articles

Cover Story: Mother-to-child transmission of HIV-1 and pediatric ART may influence virologic and immune features, resulting in differences in the infected cell populations that persist compared to adults who acquire HIV-1. Using long-amplicon proviral sequencing, we investigated the characteristics of proviruses that persisted in five children for 7–9 years on ART. We found fewer intact proviruses, fewer mutations in the major splice donor (MSD) site, and a higher proportion of proviruses with defective tat compared to adults on long-term ART. Our results suggest that immune and ART pressures may shape a qualitatively different HIV proviral landscape in children that may influence targets for measuring and eliminating the HIV reservoir and achieving remission without ART. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (153)

  • Article
  • Open Access
987 Views
10 Pages

16 July 2025

Enteroviruses (EVs) cause broad clinical manifestations, particularly in children. Certain serotypes have been implicated in respiratory infections; however, epidemiological studies analyzing EV circulation based on clinical respiratory specimens are...

  • Review
  • Open Access
1 Citations
1,357 Views
21 Pages

16 July 2025

Improved antiretroviral therapy (ART) has significantly increased the life expectancy of people living with HIV (PLWH). At the same time, other complications like metabolic syndrome (MetS) are coming up as new challenges to handle. This review aims t...

  • Article
  • Open Access
1,164 Views
17 Pages

Entry Inhibitors of SARS-CoV-2 Targeting the Transmembrane Domain of the Spike Protein

  • Kristin V. Lyles,
  • Shannon Stone,
  • Priti Singh,
  • Lila D. Patterson,
  • Janhavi Natekar,
  • Heather Pathak,
  • Rohit K. Varshnaya,
  • Amany Elsharkawy,
  • Dongning Liu and
  • Shubham Bansal
  • + 9 authors

16 July 2025

Despite current vaccines and therapeutics targeting SARS-CoV-2, the causative agent of the COVID-19 pandemic, cases remain high causing a burden on health care systems. Spike-protein mediated membrane fusion of SARS-CoV-2 is a critical step in viral...

  • Article
  • Open Access
1,076 Views
12 Pages

Retinal Epithelial Neutralization Assay Optimizes AAV Serotype Selection for Ocular Gene Therapy

  • Yao Li,
  • Yujia Chen,
  • Nan Huo,
  • Zuyuan Jia,
  • He Huang,
  • Zhenghao Zhao,
  • Shipo Wu and
  • Lihua Hou

15 July 2025

Adeno-associated virus (AAV) vectors face a critical translational challenge in ocular gene therapy due to pre-existing neutralizing antibodies (NAbs) whose seroprevalence limits patient eligibility. Standard NAb detection using non-ocular cell model...

  • Perspective
  • Open Access
1,224 Views
25 Pages

The Emerging Role of Omics-Based Approaches in Plant Virology

  • Viktoriya Samarskaya,
  • Nadezhda Spechenkova,
  • Natalia O. Kalinina,
  • Andrew J. Love and
  • Michael Taliansky

15 July 2025

Virus infections in plants are a major threat to crop production and sustainable agriculture, which results in significant yield losses globally. The past decade has seen the development and deployment of sophisticated high-throughput omics technolog...

  • Review
  • Open Access
3 Citations
2,114 Views
22 Pages

The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications

  • Alaa A. A. Aljabali,
  • Kenneth Lundstrom,
  • Altijana Hromić-Jahjefendić,
  • Nawal Abd El-Baky,
  • Debaleena Nawn,
  • Sk. Sarif Hassan,
  • Alberto Rubio-Casillas,
  • Elrashdy M. Redwan and
  • Vladimir N. Uversky

15 July 2025

Narrative review synthesizes the most current literature on the SARS-CoV-2 XEC variant, focusing on its genomic evolution, immune evasion characteristics, epidemiological dynamics, and public health implications. To achieve this, we conducted a struc...

  • Review
  • Open Access
1,285 Views
21 Pages

15 July 2025

Parvoviruses have compact genomic organizations with overlapping open reading frames and thus utilize alternative RNA processing strategies, alternative splicing, alternative polyadenylation, and alternative translation mechanisms to generate a range...

  • Review
  • Open Access
1 Citations
1,967 Views
16 Pages

15 July 2025

The relentless emergence of RNA viruses poses a perpetual threat to global public health, necessitating continuous efforts in surveillance, discovery, and understanding of these pathogens. This review provides a comprehensive update on recent advance...

  • Article
  • Open Access
1,005 Views
14 Pages

Adrenomedullin Therapy for Moderate-to-Severe COVID-19 Pneumonia: Double-Blind Placebo-Controlled Phase 2a Trial

  • Toshihiro Kita,
  • Norio Ohmagari,
  • Sho Saito,
  • Hiroshi Mukae,
  • Takahiro Takazono,
  • Taka-Aki Nakada,
  • Tadanaga Shimada,
  • Yuji Hirai,
  • Yuichiro Shindo and
  • Kosaku Komiya
  • + 15 authors

14 July 2025

Adrenomedullin (AM) is a bioactive peptide that is strongly induced during severe inflammation, including pneumonia and sepsis, and serves as an organ-protective factor. The plasma concentration of AM is markedly increased in the novel coronavirus di...

of 16

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Viruses - ISSN 1999-4915