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Marine Drugs, Volume 4, Issue 1

2006 March - 4 articles

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Articles (4)

  • Communication
  • Open Access
8 Citations
8,971 Views
6 Pages

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

  • Yusuke Wakuda,
  • Takaaki Kubota,
  • Hiroshi Shima,
  • Tadashi Okada,
  • Shinya Mitsuhashi,
  • Naohito Aoki,
  • Kunimi Kikuchi and
  • Jun\'ichi Kobayashi

21 February 2006

Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 again...

  • Article
  • Open Access
34 Citations
9,195 Views
7 Pages

21 February 2006

The effects of seven compounds 1-7, isolated from a tropical ascidian Lissoclinum cf. badium, on IL-8 production in PMA-stimulated HL-60 cells were examined. Lissoclibadins 2 (2) and 3 (3) and lissoclinotoxin F (5) increased the IL-8 production in a...

  • Article
  • Open Access
4 Citations
9,167 Views
6 Pages

21 February 2006

Bioassay-guided isolation from the ethanol extract of a marine sponge Theonella sp. collected in Palau yielded bistheonellide A, which strongly inhibited the colony formation of Chinese hamster V79 cells (EC50 = 6.8 nM). Bistheonellide A is an actinp...

  • Article
  • Open Access
38 Citations
13,629 Views
8 Pages

Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.

  • Jaine H. H. L. De Oliveira,
  • Mirna H. R. Seleghim,
  • Christoph Timm,
  • Achim Grube,
  • Matthias Köck,
  • Gislene G.F. Nascimento,
  • Ana Claudia T. Martins,
  • Elissa G. O. Silva,
  • Ana Olívia De Souza and
  • Roberto G. S. Berlinck
  • + 4 authors

20 January 2006

Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staph...

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Mar. Drugs - ISSN 1660-3397