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Mar. Drugs 2006, 4(1), 1-8;

Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.

Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil
Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12,D-27570 Bremerhaven, Germany
Faculdade de Ciências da Saúde, Universidade Metodista de Piracicaba, Piracaba, SP, Brazil
Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, Brazil
Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil
Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista, s/n, 20940-040, Rio de Janeiro, RJ, Brazil
Author to whom correspondence should be addressed.
Received: 7 December 2005 / Accepted: 18 January 2006 / Published: 20 January 2006
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Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antibiotic-susceptible Escherichia coli and Candida albicans, as well as in antimycobacterial activity against Mycobacterium tuberculosis H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines. View Full-Text
Keywords: alkaloids; antimycobacterial; antibacterial; Pachychalina sp.; sponge alkaloids; antimycobacterial; antibacterial; Pachychalina sp.; sponge
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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De Oliveira, J.H.H.L.; Seleghim, M.H.R.; Timm, C.; Grube, A.; Köck, M.; Nascimento, G.G.; Martins, A.C.T.; Silva, E.G.O.; De Souza, A.O.; Minarini, P.R.R.; Galetti, F.C.S.; Silva, C.L.; Hajdu, E.; Berlinck, R.G.S. Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.. Mar. Drugs 2006, 4, 1-8.

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