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Marine Drugs, Volume 21, Issue 1

January 2023 - 54 articles

Cover Story: The literature published from January 2016 to December 2021 on marine-derived bacteria revealed that the Actinobacteria, especially Streptomyces, were the most predominant bacteria that produced novel compounds with anti-drug-resistant pathogens. The compounds in this review are categorized into four groups, based on their biosynthetic origins, as polyketides, amino acid derivatives, terpenoids, and of a mixed origin. These compounds were active against one or more drug-resistant pathogens such as methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, vancomycin-resistant Enterococci, multidrug-resistant Mycobacterium tuberculosis, and amphotericin B-resistant Candida albicans. Some of the compounds also showed anti-biofilm activity against the test bacteria. View this paper
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Articles (54)

  • Article
  • Open Access
3 Citations
3,966 Views
21 Pages

Paralytic Shellfish Toxins in the Gastropod Concholepas concholepas: Variability, Toxin Profiles and Mechanisms for Toxicity Reduction

  • Miriam Seguel,
  • Carlos Molinet,
  • Manuel Díaz,
  • Gonzalo Álvarez,
  • Carlos García,
  • Andrés Marín,
  • María Olga Millanao and
  • Patricio A. Díaz

6 January 2023

Harmful algal blooms of toxin-producing microalgae are recurrent in southern Chile. Paralytic shellfish poisoning (PSP) outbreaks pose the main threat to public health and the fishing industry in the Patagonian fjords. This study aims to increase und...

  • Review
  • Open Access
26 Citations
7,926 Views
25 Pages

Application of Marine Natural Products against Alzheimer’s Disease: Past, Present and Future

  • Di Hu,
  • Yating Jin,
  • Xiangqi Hou,
  • Yinlong Zhu,
  • Danting Chen,
  • Jingjing Tai,
  • Qianqian Chen,
  • Cui Shi,
  • Jing Ye and
  • Mengxu Wu
  • + 2 authors

5 January 2023

Alzheimer’s disease (AD), a neurodegenerative disease, is one of the most intractable illnesses which affects the elderly. Clinically manifested as various impairments in memory, language, cognition, visuospatial skills, executive function, etc...

  • Article
  • Open Access
13 Citations
2,902 Views
14 Pages

The Polysaccharidic Nature of the Skeleton of Marennine as Determined by NMR Spectroscopy

  • Ilhem Zebiri,
  • Boris Jacquette,
  • Nellie Francezon,
  • Mickaël Herbaut,
  • Amina Latigui,
  • Sullivan Bricaud,
  • Réjean Tremblay,
  • Pamela Pasetto,
  • Jean-Luc Mouget and
  • Jens Dittmer

4 January 2023

The water-soluble blue–green pigment marennine, produced and partly excreted by the diatom Haslea ostrearia, and known for a long time for its role in the greening of oysters, was isolated from the culture medium, purified, and analyzed by Nucl...

  • Article
  • Open Access
5 Citations
3,365 Views
11 Pages

Type-I Hemins and Free Porphyrins from a Western Australian Sponge Isabela sp.

  • Samuele Sala,
  • Stephen A. Moggach,
  • Gareth L. Nealon,
  • Jane Fromont,
  • Oliver Gomez,
  • Daniel Vuong,
  • Ernest Lacey and
  • Gavin R. Flematti

3 January 2023

Two novel free porphyrins, isabellins A and B, as well as the known compounds corallistin D and deuteroporphyrin IX were isolated from a marine sponge Isabela sp. LC-MS analysis of the crude extract revealed that the natural products were present bot...

  • Review
  • Open Access
32 Citations
6,614 Views
15 Pages

A Concise Review on the Potential Applications of Rugulopteryx okamurae Macroalgae

  • Ligia Barcellos,
  • Christopher K. Pham,
  • Gui Menezes,
  • Raúl Bettencourt,
  • Nieta Rocha,
  • Miguel Carvalho and
  • Helena P. Felgueiras

3 January 2023

The brown macroalgae of the species Rugulopteryx okamurae has reached European waters and the Strait of Gibraltar as an invasive species. The proliferation and colonization of the species in subtidal and intertidal zones of these regions imposes sign...

  • Article
  • Open Access
12 Citations
3,506 Views
19 Pages

1 January 2023

It has been reported that dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) exert therapeutic potential for the preservation of functional β-cell mass. However, the effect of dietary n-3 PUFA deficiency on pancreatic injury and whether the sup...

  • Review
  • Open Access
6 Citations
2,966 Views
14 Pages

Effect of the Marine Polyketide Plocabulin on Tumor Progression

  • Eleonora Turrini,
  • Francesca Maffei and
  • Carmela Fimognari

31 December 2022

Marine sponges represent one of the richest sources of natural marine compounds with anticancer potential. Plocabulin (PM060184), a polyketide originally isolated from the sponge Lithoplocamia lithistoides, elicits its main anticancer properties bind...

  • Review
  • Open Access
21 Citations
5,123 Views
23 Pages

31 December 2022

Coumarin and its derivatives have significantly attracted the attention of medicinal chemists and chemical biologists due to their huge range of biological, and in particular, pharmacological properties. Interesting families of coumarins have been fo...

  • Article
  • Open Access
21 Citations
5,785 Views
21 Pages

FTIR Characterization of Sulfated Polysaccharides Obtained from Macrocystis integrifolia Algae and Verification of Their Antiangiogenic and Immunomodulatory Potency In Vitro and In Vivo

  • Marilú Roxana Soto-Vásquez,
  • Paúl Alan Arkin Alvarado-García,
  • Fadia S. Youssef,
  • Mohamed L. Ashour,
  • Hanin A. Bogari and
  • Sameh S. Elhady

31 December 2022

The aim of this study was to evaluate the antiangiogenic and immunomodulatory potential of sulfated polysaccharides from the marine algae Macrocystis integrifolia characterized by FTIR. The cytotoxicity of sulfated polysaccharides was evaluated using...

  • Article
  • Open Access
7 Citations
2,927 Views
19 Pages

Bio-Guided Optimization of Cystoseira abies-marina Cosmeceuticals Extraction by Advanced Technologies

  • Gonçalo P. Rosa,
  • Andreia F. Peixoto,
  • Maria Carmo Barreto,
  • Ana M. L. Seca and
  • Diana C. G. A. Pinto

31 December 2022

Cystoseira abies-marina (reclassified as Gongolaria abies-marina) is a brown seaweed species rich in meroterpenoids, presenting interesting antioxidant, antitumor, and anti-inflammatory activities. However, there is still a lot to uncover regarding t...

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Mar. Drugs - ISSN 1660-3397