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Marine Drugs, Volume 20, Issue 1

January 2022 - 78 articles

Cover Story: Six new metabolites, including a pair of inseparable mixture of secofumitremorgins A (1a) and B (1b) which differed in the configuration at nitrogen atom, together with six known compounds, were isolated and identified from the deep-sea sediment-derived fungus Aspergillus fumigatus SD-406. Their structures were determined by detailed spectroscopic analysis, acidic hydrolysis, X-ray crystallographic analysis, J-based configuration analysis, and quantum chemical calculations. Among the compounds, 1a/1b represent a pair of novel scaffolds derived from indolediketopiperazine by cleavage of the amide bond following aromatization to give a pyridine ring. Selected compounds showed potent inhibitory activities against pathogenic bacteria and fungi. View this paper
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Articles (78)

  • Article
  • Open Access
24 Citations
3,908 Views
15 Pages

Isoquinoline Alkaloids as Protein Tyrosine Phosphatase Inhibitors from a Deep-Sea-Derived Fungus Aspergillus puniceus

  • Cheng-Mei Liu,
  • Fei-Hua Yao,
  • Xin-Hua Lu,
  • Xue-Xia Zhang,
  • Lian-Xiang Luo,
  • Xiao Liang and
  • Shu-Hua Qi

17 January 2022

Puniceusines A–N (1–14), 14 new isoquinoline alkaloids, were isolated from the extracts of a deep-sea-derived fungus, Aspergillus puniceus SCSIO z021. Their structures were elucidated by spectroscopic analyses. The absolute configuration of 9 was det...

  • Article
  • Open Access
11 Citations
3,705 Views
11 Pages

New Tripeptide Derivatives Asterripeptides A–C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2

  • Elena V. Girich,
  • Anton B. Rasin,
  • Roman S. Popov,
  • Ekaterina A. Yurchenko,
  • Ekaterina A. Chingizova,
  • Phan Thi Hoai Trinh,
  • Ngo Thi Duy Ngoc,
  • Mikhail V. Pivkin,
  • Olesya I. Zhuravleva and
  • Anton N. Yurchenko

17 January 2022

Three new tripeptide derivatives asterripeptides A–C (1–3) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute c...

  • Article
  • Open Access
17 Citations
4,630 Views
23 Pages

FGFC1 Exhibits Anti-Cancer Activity via Inhibiting NF-κB Signaling Pathway in EGFR-Mutant NSCLC Cells

  • Jingwen Feng,
  • Songlin Li,
  • Bing Zhang,
  • Namin Duan,
  • Rui Zhou,
  • Shike Yan,
  • Jeevithan Elango,
  • Ning Liu and
  • Wenhui Wu

17 January 2022

FGFC1, an active compound isolated from the culture of marine fungi Stachybotrys longispora FG216, elicits fibrinolytic, anti-oxidative, and anti-inflammatory activity. We have previously reported that FGFC1 inhibited the proliferation, migration, an...

  • Review
  • Open Access
19 Citations
5,188 Views
26 Pages

15 January 2022

The incidence of neurodegenerative diseases, such as Alzheimer’s disease (AD), increases continuously demanding the urgent development of anti-Alzheimer’s agents. Marine organisms (MO) have to create their own defenses due to the adverse...

  • Article
  • Open Access
3 Citations
4,637 Views
20 Pages

15 January 2022

Actinoporins are proteinaceous toxins known for their ability to bind to and create pores in cellular membranes. This quality has generated interest in their potential use as new tools, such as therapeutic immunotoxins. Isolated historically from sea...

  • Article
  • Open Access
19 Citations
4,409 Views
10 Pages

14 January 2022

Xanthophylls, a yellow pigment belonging to the carotenoid family, have attracted much attention for industrial applications due to their versatile nature. We report the isolation of a homo xanthophyll pigment-producing marine bacterium, identified a...

  • Article
  • Open Access
9 Citations
3,160 Views
15 Pages

14 January 2022

Marine myxobacteria present a virtually unexploited reservoir for the discovery of natural products with diverse biological functions and novel chemical scaffolds. We report here the isolation and structure elucidation of eight new deoxyenhygrolides...

  • Article
  • Open Access
13 Citations
3,288 Views
12 Pages

Chevalones H–M: Six New α-Pyrone Meroterpenoids from the Gorgonian Coral-Derived Fungus Aspergillus hiratsukae SCSIO 7S2001

  • Xia-Yu Chen,
  • Qi Zeng,
  • Yu-Chan Chen,
  • Wei-Mao Zhong,
  • Yao Xiang,
  • Jun-Feng Wang,
  • Xue-Feng Shi,
  • Wei-Min Zhang,
  • Si Zhang and
  • Fa-Zuo Wang

14 January 2022

Six new α-pyrone meroterpenoid chevalones H–M (1–6), together with six known compounds (7–12), were isolated from the gorgonian coral-derived fungus Aspergillus hiratsukae SCSIO 7S2001 collected from Mischief Reef in the South...

  • Article
  • Open Access
26 Citations
4,926 Views
13 Pages

13 January 2022

Japanese Spanish mackerel (JSM) (Scomberomorus niphonius) is a marine fish species containing health-beneficial polyunsaturated fatty acids (PUFAs). In the present study, the quality of JSM by-products oils extracted by supercritical CO2 (SC-CO2) and...

  • Review
  • Open Access
86 Citations
7,272 Views
19 Pages

The Microstructure, Antibacterial and Antitumor Activities of Chitosan Oligosaccharides and Derivatives

  • Dawei Yu,
  • Jiayao Feng,
  • Huimin You,
  • Shipeng Zhou,
  • Yan Bai,
  • Jincan He,
  • Hua Cao,
  • Qishi Che,
  • Jiao Guo and
  • Zhengquan Su

13 January 2022

Chitosan obtained from abundant marine resources has been proven to have a variety of biological activities. However, due to its poor water solubility, chitosan application is limited, and the degradation products of chitosan oligosaccharides are bet...

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Mar. Drugs - ISSN 1660-3397Creative Common CC BY license