2026 May - 205 articles
Background and Objectives: Perforated peptic ulcer (PPU) is an emergent condition managed by surgical intervention. No conclusive evidence has been produced regarding the need for drain placement after primary repair. Our meta-analysis aimed to provi...
Background and Objectives: Obstructive sleep apnea (OSA) is a common disorder associated with significant cardiovascular, metabolic, and neurocognitive consequences. The STOP and STOP-BANG questionnaires are widely used screening tools for identifyin...
Background and Objectives: Endometriosis is a multifactorial gynecological condition associated with impaired fertility; however, its impact on embryo competence remains incompletely understood. This study aimed to evaluate embryo competence through...
Background and Objectives: Although clinically useful, homologous recombination deficiency (HRD) testing has recently been more broadly adopted in ovarian cancer (OC) management. The VALIDATE study evaluated HRD status and treatment patterns in patie...
Background and Objectives: Temporomandibular disorders (TMDs) are heterogeneous conditions whose clinical expression cannot be fully explained by local or structural findings alone. DC/TMD Axis II provides a psychobehavioral framework for assessing p...
Background and Objectives: Small bowel obstruction (SBO) is a common surgical emergency, accounting for 15–20% of acute general surgical admissions. Despite the Bologna Guideline’s introduction to the surgical community almost a decade ag...
Background and Objectives: This study evaluated the effect of two wound closure methods—polypropylene sutures and a butyl-2-cyanoacrylate tissue adhesive—on the rate of soft tissue regeneration following palatal donor site harvesting. A b...
Background and Objectives: Pulmonary hypertension (PH) remains associated with substantial mortality despite advances in treatment. Although prognostic factors have been widely described at sea level, their behavior in populations living at high alti...
Background and Objectives: Healthcare-associated infections (HAIs) remain a major cause of morbidity and mortality among hospitalized patients. During the COVID-19 pandemic, SARS-CoV-2 infection emerged as a major contributor to HAIs, alongside Clost...
Background and Objectives: Knee osteoarthritis (KOA) is a degenerative joint disease that affects quality of life through pain, impaired functional performance, and altered gait patterns. Hydrotherapy is a well-tolerated form of physical rehabilitati...
Background and Objectives: SGLT2 inhibitors increase hemoglobin and hematocrit in multiple clinical settings, an effect increasingly attributed to stimulation of erythropoiesis rather than hemoconcentration. However, most mechanistic evidence derives...
Background and Objectives: Neoadjuvant chemotherapy (NAC) followed by radical cystectomy is the standard of care for eligible patients with locally advanced bladder cancer (LABC). However, adjuvant chemotherapy (AC) remains widely used in real-world...
Background and Objectives: Cardiac implantable electronic device (CIED) infections remain among the most serious complications of pacemaker, implantable cardioverter-defibrillator, and cardiac resynchronization therapy procedures. They are associated...
Background and Objectives: Pericoronary adipose tissue (PCAT) attenuation measured on coronary CT angiography is a promising imaging biomarker of coronary inflammation; however, absolute values may be influenced by technical and inter-individual vari...
Background and Objectives: Spondylodiscitis is a severe spinal infection associated with substantial mortality. Standard diagnostic imaging is often limited to the symptomatic spinal segment, which may fail to detect infection foci in other spinal re...
Background and Objectives: We aimed to determine whether gynecologic cancer–related factors are associated with postoperative clinically significant cognitive decline (CCD) after accounting for age and comorbidity using competing-risk models. M...
Background and Objectives: FLOT is a highly effective first-line treatment for metastatic gastric cancer and offers a favorable safety profile. Clinical studies investigating the FLOT regimen have reported varying outcomes depending on the infusion d...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly associated with metabolic abnormalities, shares pathophysiological pathways with metabolic syndrome, and has become a leading cause of chronic liver disease in industrialize...
Background and Objectives: There is limited evidence supporting the incorporation of dietary patterns into heart failure (HF) management. The Dietary Approaches to Stop Hypertension (DASH) diet is linked to cardiovascular disease prevention, but evid...
Background and Objectives: Perioperative fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) is the standard of care for resectable gastric and gastroesophageal junction adenocarcinoma; however, up to 50% of patients develop metastatic recurr...
Background and Objectives: Subcortical bone cysts at the tibial attachment of the medial meniscus posterior root (MMPR) may reflect chronic degenerative changes; however, their clinical significance in medial meniscus posterior root tear (MMPRT) rema...
Background and Objectives: This study aimed to evaluate the diagnostic performance of endoscopic ultrasound (EUS) in comparison with computed tomography (CT) and magnetic resonance imaging (MRI) in the characterization of pancreatic lesions, and to a...
Background and Objectives: Papillary thyroid microcarcinoma (PTMC) is generally indolent; however, a subset exhibits aggressive features, reflecting biological heterogeneity. In the era of treatment de-escalation and active surveillance, accurate ris...
Background and Objectives: Dysfunction of the airway epithelial barrier is increasingly recognized as an early pathogenic mechanism in allergic respiratory diseases. Although individual aeroallergens such as ragweed (RW) pollen and house dust mite (H...
Background and Objectives: Cardiovascular risk prediction models (RPMs) are widely used to guide statin initiation in primary prevention, yet the extent to which different models produce concordant treatment decisions in the same population remains i...
Background and Objectives: Adolescent idiopathic scoliosis (AIS) may influence pelvic orientation and lower-limb alignment; however, data on coronal lower-limb alignment after completion of spinal treatment remain limited. This study aimed to evaluat...
Background and Objectives: Minimally invasive cervical spine surgery (MIS-CSS) relies heavily on intraoperative fluoroscopic imaging, raising concerns about radiation exposure to patients and surgical staff. Unlike lumbar MIS, cervical-specific radia...
Background and Objectives: Paramedian cervical interlaminar epidural steroid injection (CESI) is commonly used for cervical radicular pain and is considered safer than the transforaminal approach. However, its clinical effectiveness may be influenced...
Background and Objectives: Benign prostatic hyperplasia (BPH) is a progressive, androgen-dependent condition driven by dihydrotestosterone (DHT). 5α-reductase inhibitors (5-ARIs), including finasteride and dutasteride, target this pathway and p...
Background/Objectives: Dietary adherence to the Dietary Approaches to Stop Hypertension (DASH) pattern is associated with lower blood pressure; however, most prior studies have relied on office-based measurements and non-specific dietary assessment t...
Background and Objectives: This study aimed to evaluate the impact of body mass index (BMI) on post- operative outcomes in patients undergoing aortic arch repair with the frozen elephant trunk technique (FET). Materials and Methods: A total of 387 pa...
Background and Objectives: Cardiovascular disease (CVD) is the leading cause of death globally. The World Health Organization has called for investigations into traditional systems of medicine for CVD prevention. Ayurveda includes a classical herbal...
Background and Objectives: To evaluate the impact of Holmium Laser Enucleation of the Prostate (HoLEP) versus Transurethral Resection of the Prostate (TURP) on cognitive function and psychological well-being three months post-surgery. Materials and M...
Background and Objectives: Elective electrical cardioversion (eECV) in patients with atrial fibrillation (AF) or atrial flutter is associated with a low risk of thromboembolic events (TEs) when adequate anticoagulation is provided. However, the role...
Background and Objectives: Multiple sclerosis (MS) is characterized by progressive disability and a spectrum of motor and cognitive impairments. Exergames and virtual reality (VR) are proposed as motivating exercise tools, potentially useful for impr...
Background and Objectives: To evaluate ocular findings in women with cervical HPV positivity undergoing loop electrosurgical excision procedure (LEEP) for cervical dysplasia and to assess conjunctival/eyelid papilloma and other ocular findings in thi...
Background and Objectives: Conventional stainless-steel orthodontic molar bands may exhibit limited anatomical adaptation, favoring plaque retention and periodontal inflammation. This study aimed to compare the periodontal outcomes of standard bands...
Background and Objectives: Pediatric forearm fractures are among the most common childhood injuries. COVID-19-related societal restrictions, including school closures and suspension of sports activities, altered children’s daily routines and ma...
Background and Objectives: Treatment-resistant depression (TRD) is a major clinical challenge in the management of major depressive disorder (MDD). While pharmacogenetics has been suggested to be clinically useful in guiding antidepressant treatment,...
Background and Objectives: Although perioperative FLOT improves outcomes in locally advanced gastric cancer, postoperative recurrence remains frequent. This study evaluated the prognostic value of a PET-derived SUVmax/albumin ratio integrating tumor...
Background and Objectives: Prolonged contact between oral mucosa and dental amalgam restorations may influence local epithelial homeostasis, but the remodeling profile of clinically non-dysplastic mucosa exposed to long-standing amalgam remains insuf...
Background and Objectives: Chemoports are essential for long-term chemotherapy. They are typically inserted either by interventional radiologists in an interventional radiology (IR) suite or by surgeons in the operating room (OR). Although both appro...
Graves’ orbitopathy (GO) is a representative extrathyroidal manifestation of autoimmune thyroid disease. Despite extensive research, the precise pathogenic mechanisms remain incompletely understood. Moreover, the lack of an ideal animal model h...
Cutaneous melanoma remains a highly lethal malignancy once metastatic. Current prognostic stratification relies primarily on staging and serum lactate dehydrogenase (LDH), which incompletely captures inter-patient biological heterogeneity. Increasing...
Background and Objectives: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are widely performed procedures with high success rates but relevant postoperative complications. Preoperative nutritional status is a key modifiable risk facto...
Background and Objectives: Prognostic assessments in grade 4 diffuse astrocytic tumors primarily depend on clinical and molecular characteristics, with radiological attributes frequently assessed in isolation. In this study, we explored whether an in...
Backgroud and Objectives: To evaluate conventional Doppler indices and the novel middle cerebral artery (MCA) diastolic deceleration area (DDA) in pregnancies complicated by gestational diabetes mellitus (GDM), and to explore their associations with...
Background and Objectives: Chronic neck pain is a prevalent condition linked to functional disability and maladaptive pain-related behaviors. Although the physical and psychosocial impairments have been extensively studied in the literature, the fact...
Background and Objectives: Hepatic encephalopathy (HE) management becomes particularly challenging in older patients. This study aimed to evaluate the physician-reported diagnostic approaches, therapeutic strategies, and specific challenges in managi...
Background: There are still insufficient studies based on large patient cohorts that evaluate both functional and surgical outcomes after internal hemipelvectomy and 3D-printed endoprosthesis implantation. This study aimed to determine how the method...
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