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Medicina
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The Challenges and Prospects in Clinical Cardiology and Angiology: 2nd...
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The Challenges and Prospects in Clinical Cardiology and Angiology: 2nd Edition

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 415

Special Issue Editors

Dr. Vincenzo Zaccone

E-Mail Website
Guest Editor
Internal and Subintensive Medicine, Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy
Interests: endothelial cells; atherosclerosis; endothelial progenitor cells; deep vein thrombosis; pulmonary embolism; cardiovascular regenerative medicine; sepsis and septic shock
Special Issues, Collections and Topics in MDPI journals
Dr. Giulio Francesco Romiti

E-Mail Website
Guest Editor
Department of Translational and Precision Medicine, Sapienza University of Rome, 00161 Rome, Italy
Interests: antithrombotic treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases remain the leading cause of mortality worldwide, necessitating the continuous exploration of innovative diagnostic techniques, treatment strategies and preventive measures.

This Special Issue aims to delve into the multifaceted landscape of challenges and prospects that shape the practice of clinical cardiology and angiology in today's medical landscape. From the evolving understanding of complex pathophysiological mechanisms to the development of innovative diagnostic tools and therapeutic interventions, this collection of articles seeks to provide a comprehensive overview of the current state of clinical cardiology and angiology.

In this Special Issue, renowned experts and researchers will contribute their insights on a range of topics, including the identification and management of risk factors, breakthroughs in non-invasive imaging techniques, personalized approaches to treatment and the integration of digital health technologies in cardiovascular practice. By addressing these challenges head-on and exploring potential future directions, this collection aims to foster a deeper understanding of the dynamic field of cardiology and angiology, ultimately leading to improved patient outcomes and enhanced cardiovascular care.

We are seeking original research, reviews, clinical trials and opinion pieces exploring challenges and prospects in clinical cardiology and angiology. Innovative diagnostics, treatments, translational research and healthcare delivery topics are welcome, contributing to advancements in cardiovascular and vascular care.

Dr. Vincenzo Zaccone
Dr. Giulio Francesco Romiti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiology

  • angiology

  • cardiovascular diseases

  • vascular health

  • diagnostic techniques

  • treatment strategies

  • translational research

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Published Papers (1 paper)

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Research

18 pages, 8060 KB  
Article
The Role of Cardiovascular Risk Prediction Model Selection in Primary Prevention: An Observational Study of Statin Eligibility Agreement Across Nine Scores in a Lithuanian Primary-Prevention Cohort
by Petras Navickas, Sigita Glaveckaitė, Laura Lukavičiūtė-Navickienė, Agnė Šatrauskienė, Arvydas Baranauskas, Egidija Rinkūnienė, Emilija Meškėnė, Vaida Šileikienė, Edita Lycholip and Aleksandras Laucevičius
Medicina 2026, 62(5), 979; https://doi.org/10.3390/medicina62050979 (registering DOI) - 17 May 2026
Viewed by 167
Abstract
Background and Objectives: Cardiovascular risk prediction models (RPMs) are widely used to guide statin initiation in primary prevention, yet the extent to which different models produce concordant treatment decisions in the same population remains insufficiently characterized. We compared statin eligibility across nine [...] Read more.
Background and Objectives: Cardiovascular risk prediction models (RPMs) are widely used to guide statin initiation in primary prevention, yet the extent to which different models produce concordant treatment decisions in the same population remains insufficiently characterized. We compared statin eligibility across nine commonly used RPMs: SCORE2, PREVENT, PCE, ASSIGN, FRS-hCHD, AusCVDRisk, MESA, QRISK3, and RRS. Materials and Methods: We performed a cross-sectional analysis of 11,174 adults aged 40–65 years with metabolic syndrome enrolled in the Lithuanian High Cardiovascular Risk primary prevention program (LitHiR) and evaluated them at a single tertiary center during 2006–2023. Statin eligibility was determined for each RPM using guideline-mapped treatment thresholds. Pairwise agreement was assessed using Cohen’s κ, Gwet’s AC1, Positive and Negative Percent Agreement (PPA/NPA), the Jaccard index, and McNemar testing. Analyses were repeated by sex. Consensus eligibility was defined as treatment recommended by at least k of nine models. Results: Eligibility varied more than twenty-fold, from 67.39% (7530/11,174) with SCORE2 to 3.03% (339/11,174) with AusCVDRisk; intermediate estimates included PREVENT at 44.83%, QRISK3 at 39.00%, and PCE at 37.97%. Overall pairwise agreement was modest: κ ranged from 0.03 (SCORE2 vs. AusCVDRisk) to 0.67 (QRISK3 vs. ASSIGN), with a median κ of 0.38 (IQR: 0.19–0.51). Median AC1 was 0.58 (IQR 0.37–0.68). Agreement was stronger for non-eligibility than for eligibility (median NPA: 0.82 vs. median PPA: 0.53). Consensus eligibility declined from 73.5% at k = 1 to 45.1% at k = 3, 30.0% at k = 5, and 1.87% at k = 9, with the greatest sex divergence at intermediate stringency. Conclusions: In this real-world cohort with elevated cardiometabolic risk, statin eligibility was highly dependent on RPM choice and showed only modest inter-model concordance. Increasing consensus stringency rapidly reduced eligibility, indicating that RPM selection and embedded thresholds substantially influence statin treatment decisions in primary prevention. Full article
(This article belongs to the Special Issue The Challenges and Prospects in Clinical Cardiology and Angiology: 2nd Edition)
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