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Medicina
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New Insights into Heart Failure: 2nd Edition
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New Insights into Heart Failure: 2nd Edition

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 15 September 2026 | Viewed by 993

Editors

Dr. Nilima Rajpal Kundnani

E-Mail Website
Guest Editor
1. Prevention and Cardiovascular Recovery, Department VI-Cardiology, University Clinic of Internal Medicine and Ambulatory Care, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
2. Research Centre of Timisoara Institute of Cardiovascular Diseases, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Interests: preventive medicine; cardiology; AI; evidence based medicine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Simona Dragan

E-Mail Website
Guest Editor
1. Cardiovascular Recovery, Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
2. Research Centre of Timisoara Institute of Cardiovascular Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Interests: cardiovascular disease; atrial fibrillation; heart failure; stroke; coronary artery disease; cardiomyopathy; physical exercise or training; quality of life; anticoagulation; cardiac rehabilitation; primary and secondary prevention; valvular heart diseases; congenital heart disease; cardio genetics; clinical cardiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue on “New Insights into Heart Failure: 2nd Edition” seeks to address the advancements in the diagnosis, treatment, and prevention of heart failure (HF).

HF is a clinical syndrome associated with increased morbidity, mortality, and healthcare costs. Heart failure affects about 26 million people worldwide, with more than 960,000 new cases each year. Left ventricular (LV) failure causes shortness of breath and fatigue, and right ventricular (RV) failure causes peripheral and abdominal fluid accumulation, but the ventricles can be involved together or separately. A wide variety of coexisting pathologies, diseases, or conditions can be found in HF patients, both cardiovascular and non-cardiovascular in nature, exhibiting diverse clinical relevance. The complex inter-relationship of comorbidities and their impact on the cardiovascular system contribute to the features of HF, both with reduced (HFrEF) and preserved ejection fraction (HFpEF). Hence, it can be stated that knowledge on the coexisting morbidities helps us to determine the different phenotypes and consequences of HF. Understanding the pathogenesis and its complex associations with comorbidities can play a pivotal role in the prevention and treatment of HF.

For this Special Issue, we invite contributions from researchers, clinicians, and experts in the field to explore the diverse challenges associated with heart failure, encompassing aspects such as etiology, diagnosis, treatment modalities, and patient care.

This Special Issue is now open for submissions (including original research articles, and review papers) from clinicians and researchers in cardiovascular medicine and as well as researchers and clinicians specializing in different areas (i.e., metabolic diseases, pneumology, hematology, intensive care medicine, rheumatology, endocrinology, nephrology, internal medicine, family doctors, etc.).

Dr. Nilima Rajpal Kundnani
Prof. Dr. Simona Dragan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • risk factors
  • treatment
  • device therapy
  • biomarkers
  • aging
  • cardiovascular disease
  • coronary artery disease
  • valvular heart disease
  • arrythmias
  • stroke
  • COPD
  • cancers

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Related Special Issue

Published Papers (2 papers)

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Research

18 pages, 1160 KB  
Article
Differential Associations of Oxidative Biomarkers with Symptomatic and Systolic Severity in Heart Failure
by Aleksandra Arsić, Bojana Kisić, Vladan Perić, Ivana Stevanović, Ana Savić Radojević, Zoran Bukumirić, Ilija Dragojević, Marija Vasić, Martin Popević, Dragiša Rašić and Snežana Hadžistević
Medicina 2026, 62(6), 1108; https://doi.org/10.3390/medicina62061108 - 6 Jun 2026
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Abstract
Background and Objectives: Oxidative stress is recognized as an important contributor to heart failure (HF) pathophysiology, but the relationships of individual oxidative and antioxidant biomarkers with symptomatic severity and systolic dysfunction remain insufficiently defined. This study examined circulating oxidative and nitrosative stress [...] Read more.
Background and Objectives: Oxidative stress is recognized as an important contributor to heart failure (HF) pathophysiology, but the relationships of individual oxidative and antioxidant biomarkers with symptomatic severity and systolic dysfunction remain insufficiently defined. This study examined circulating oxidative and nitrosative stress markers across New York Heart Association (NYHA) classes and left ventricular ejection fraction (LVEF) categories in HF and their associations with HF severity. Materials and Methods: In this case–control study, 85 patients with HF and 33 healthy controls were included. Malondialdehyde (MDA), nitrates and nitrites (NOx), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), sulfhydryl (SH) groups, and NT-proBNP were measured. Group differences were analyzed using the Kruskal–Wallis test with post hoc comparisons. Adjusted ordinal logistic regression models examined associations with NYHA class and LVEF category, and receiver operating characteristic (ROC) analysis evaluated discriminatory performance. Results: Compared with controls, all biomarkers differed significantly across NYHA classes and LVEF categories (all p < 0.001). In separate adjusted models, higher NOx, MDA, and NT-proBNP were associated with worse NYHA class and more impaired LVEF, whereas higher antioxidant marker levels were associated with lower odds of severe HF. In combined models, NOx remained independently associated with worse NYHA class (OR 1.07, 95% CI 1.04–1.11; p < 0.001), while MDA remained independently associated with more impaired LVEF (OR 1.02, 95% CI 1.00–1.03; p = 0.022). NT-proBNP showed the best discrimination for NYHA III/IV versus I/II (AUC 0.966), while among oxidative biomarkers NOx performed best for symptomatic severity (AUC 0.782) and MDA for LVEF ≤ 40% (AUC 0.751). Conclusions: HF is characterized by increased oxidative and nitrosative stress together with reduced antioxidant defense. NOx appears more closely related to symptomatic severity, whereas MDA appears more closely related to systolic dysfunction. However, NT-proBNP remained the strongest overall discriminator. NOx and MDA may provide complementary mechanistic information on redox imbalance across HF severity categories. Full article
(This article belongs to the Special Issue New Insights into Heart Failure: 2nd Edition)
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13 pages, 657 KB  
Article
Dietary Approaches to Stop Hypertension (DASH) Diet, Incident Heart Failure and Its Associated Risk Factors in Australian Women
by Lee Patricia Liao, Simone Marschner, Gary C. H. Gan, Liza Thomas, Allison Hodge, Haeri Min, Luigi Fontana, Sarah Zaman and Anushriya Pant
Medicina 2026, 62(5), 985; https://doi.org/10.3390/medicina62050985 - 18 May 2026
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Abstract
Background and Objectives: There is limited evidence supporting the incorporation of dietary patterns into heart failure (HF) management. The Dietary Approaches to Stop Hypertension (DASH) diet is linked to cardiovascular disease prevention, but evidence correlating DASH adherence to HF risk is sparse. This [...] Read more.
Background and Objectives: There is limited evidence supporting the incorporation of dietary patterns into heart failure (HF) management. The Dietary Approaches to Stop Hypertension (DASH) diet is linked to cardiovascular disease prevention, but evidence correlating DASH adherence to HF risk is sparse. This study is the first prospective investigation into the relationship between the DASH diet, incident HF and its associated risk factors—hypertension and diabetes mellitus (DM)—in Australian women. Materials and Methods: Survey data (2001–2022) from the Australian Longitudinal Study on Women’s Health (ALSWH) was analysed, where DASH diet scores were calculated from food frequency questionnaire (FFQ) responses and categorised into quintiles. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between DASH adherence and incident HF. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% CIs for secondary endpoints, hypertension and DM, and dietary exposure was modelled as a time-varying covariate. Results: 10 594 women (mean age 52.5 ± 1.45 years) participated and, at 21-year follow-up, there were 136 (1.3%) cases of HF, 2182 (20.6%) and 994 (5.7%) cases of hypertension and DM, respectively. After adjustment for covariates (including age and socioeconomic factors), no association was found between the highest DASH quintile and incident HF [OR 0.73, 95% CI: 0.37–1.43; p = 0.20]. However, adjusted HRs for hypertension and DM—0.73 (95% CI: 0.63–0.84; p < 0.001) and 0.65 (95% CI: 0.53–0.81; p < 0.001), respectively—indicated significant associations. Conclusions: In Australian women, DASH diet adherence was associated with a significantly lower risk of hypertension and DM, both of which are HF risk factors. The finding of no direct statistically significant association between the DASH diet and incident HF might reflect the small incidence of HF in our cohort. Full article
(This article belongs to the Special Issue New Insights into Heart Failure: 2nd Edition)
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