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Medicina
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Progress in Venous Thromboembolism Research
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Progress in Venous Thromboembolism Research

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1959

Special Issue Editor

Dr. Mihaela Hostiuc

E-Mail Website
Guest Editor
Department of Internal Medicine, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: hypertension; atrial fibrillation; heart failure; venous thromboembolism (deep vein thrombosis, pulmonary thromboembolism); thrombophilias
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Venous thromboembolism (VTE) is the third most frequent cardiovascular disease after myocardial infarction and ischemic stroke. The burden of disease is enormous, considering the risk of death and complications such as recurrence, post-thrombotic syndrome, chronic thromboembolic pulmonary disease, or bleeding while on anticoagulants.

Despite these, VTE is a preventable disease. Progress in reducing the disease burden both through prevention and treatment has been made during recent years. The development of risk assessment models allows for a better selection of patients for prophylaxis. Choosing the appropriate medications, doses and duration of prophylaxis are very important steps in patient management for both inpatients and outpatients.

Improvement of the diagnosis algorithm will decrease the costs and the number of misdiagnosed cases.

Progress in treatment strategies (medical and interventional) will minimize mortality and morbidity. New anticoagulant drugs targeting factor XI are being evaluated in phase 3 clinical trials in people with atrial fibrillation. Their future use in patients with VTE will mark a big step forward that may improve outcomes in this population.

Considering the above, I propose this Special Issue on the Progress in Venous Thromboembolism Research, which will focus on progress in prevention, diagnosis, treatment, and prevention of complications.

Dr. Mihaela Hostiuc
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • venous thromboembolism
  • cardiovascular disease
  • post-thrombotic syndrome
  • chronic thromboembolic pulmonary disease
  • prevention

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Published Papers (2 papers)

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Review

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23 pages, 451 KB  
Review
Etiology and Risk Factors for Splanchnic Vein Thrombosis in Non-Cirrhotic, Non-Neoplastic Patients: A Narrative Review
by Mihaela Hostiuc and Ionut Negoi
Medicina 2025, 61(5), 933; https://doi.org/10.3390/medicina61050933 - 21 May 2025
Viewed by 1091
Abstract
Splanchnic vein thrombosis (SVT) is a heterogeneous group of disorders affecting the portal, mesenteric, splenic, and hepatic veins. While frequently associated with liver cirrhosis and malignancy, SVT also occurs in non-cirrhotic, non-neoplastic patients. This narrative review evaluates the epidemiology and risk factors for [...] Read more.
Splanchnic vein thrombosis (SVT) is a heterogeneous group of disorders affecting the portal, mesenteric, splenic, and hepatic veins. While frequently associated with liver cirrhosis and malignancy, SVT also occurs in non-cirrhotic, non-neoplastic patients. This narrative review evaluates the epidemiology and risk factors for SVT in this population. The prevalence and incidence of SVT in non-cirrhotic, non-neoplastic patients remain incompletely characterized, with estimates varying widely across studies. The clinical significance of SVT relates to potential complications, including intestinal ischemia, portal hypertension, and a possible underlying systemic disorder. Risk factors for SVT can be categorized into local abdominal conditions, thrombophilias, and systemic disorders. Local factors include inflammatory bowel disease, pancreatitis, abdominal surgery, and trauma. Thrombophilias, both inherited and acquired, are significant contributors to SVT risk. Systemic conditions associated with SVT include autoimmune disorders, pregnancy, hematological diseases, and infections. The complex interplay of these risk factors highlights the need for a comprehensive evaluation of SVT patients. Early recognition and management of these conditions can prevent potentially life-threatening complications and guide decisions regarding anticoagulation and long-term follow-up. Full article
(This article belongs to the Special Issue Progress in Venous Thromboembolism Research)

Other

Jump to: Review

21 pages, 2014 KB  
Systematic Review
Interventional Procedures in Deep Venous Thrombosis Treatment: A Review of Techniques, Outcomes, and Patient Selection
by Arkadiusz Kacała, Mateusz Dorochowicz, Jędrzej Fischer, Adrian Korbecki, Aleksander Truszyński, Anna Madura, Krzysztof Dyś, Andrzej Szuba and Maciej Guziński
Medicina 2025, 61(8), 1476; https://doi.org/10.3390/medicina61081476 - 18 Aug 2025
Viewed by 649
Abstract
Background and Objectives: Deep venous thrombosis (DVT) is associated with pulmonary embolism and long-term complications such as post-thrombotic syndrome (PTS). Anticoagulation prevents thrombus extension but does not actively remove clot. Interventional techniques, including catheter-directed thrombolysis, mechanical and pharmacomechanical thrombectomy, and venous stenting, have [...] Read more.
Background and Objectives: Deep venous thrombosis (DVT) is associated with pulmonary embolism and long-term complications such as post-thrombotic syndrome (PTS). Anticoagulation prevents thrombus extension but does not actively remove clot. Interventional techniques, including catheter-directed thrombolysis, mechanical and pharmacomechanical thrombectomy, and venous stenting, have been introduced to restore venous patency and reduce complications. This systematic review summarizes current evidence on outcomes, safety, and patient selection for these procedures. Materials and Methods: A systematic search of PubMed, EMBASE, Cochrane Library, and Web of Science was conducted for studies published between January 2000 and February 2024. Eligible studies included randomized controlled trials, systematic reviews, meta-analyses, and observational studies with ≥20 patients. Extracted outcomes were technical success, thrombus clearance, venous patency, PTS, quality of life, and complications. Risk of bias was assessed using the Cochrane Risk of Bias Tool, Newcastle–Ottawa Scale, and AMSTAR-2. Results: Of 456 records screened, 35 studies were included. Randomized trials (CaVenT, ATTRACT, CAVA) showed that catheter-directed and pharmacomechanical approaches improved venous patency and reduced moderate-to-severe PTS in selected patients with iliofemoral DVT, though overall benefit was variable. Mechanical thrombectomy devices (e.g., AngioJet, ClotTriever, FlowTriever) achieved high thrombus clearance and shorter procedural times, with device-specific complication profiles. Observational data demonstrated venous stenting patency rates of 74–89% at 12 months. Study heterogeneity limited direct comparisons. Conclusions: Interventional procedures can reduce PTS and improve outcomes in carefully selected patients, particularly those with acute iliofemoral DVT. Modern mechanical and pharmacomechanical techniques enhance efficiency and safety, while venous stenting addresses underlying obstructions. Further high-quality trials with long-term follow-up are needed to define optimal patient selection and comparative effectiveness. Full article
(This article belongs to the Special Issue Progress in Venous Thromboembolism Research)
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