Sensors, Volume 25, Issue 4
2025 February-2 - 291 articles
Cover Story: The human growth hormone (hGH) is a polypeptide hormone synthesized and secreted by the anterior pituitary gland, with excess levels linked to acromegaly-inducing pituitary adenomas and deficiencies associated with conditions such as short stature and Turner’s syndrome. This study explores the real-time biosensing of hGH using a microfluidic optical biosensor based on Reflectometric Interference Fourier Transform Spectroscopy (RIFTS). The platform features a nanoporous anodic alumina (NAA) monolayer, fabricated via two-step anodization to achieve 30–35 nm pores, later widened to 45 nm for enhanced sensitivity. Surface functionalization further improves selectivity toward hGH. The system exhibits a linear detection range of 12.5–100 µg/mL with a detection limit of 10.6 µg/mL, offering a cost-effective, rapid, and portable biosensing solution for clinical and diagnostic applications. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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