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International Journal of Molecular Sciences, Volume 25, Issue 16

August-2 2024 - 579 articles

Cover Story: This review discusses advancements in antibody–drug conjugates (ADCs) with metal-based and nature-inspired payloads, focusing on synthetic strategies for antibody conjugation. Traditional methods like maleimide and succinimide conjugation are widely used, but emerging techniques, such as photoconjugation, offer milder conditions and better selectivity. ADCs enhance cancer treatment by combining monoclonal antibodies’ specificity with chemotherapy drugs’ cytotoxicity, resulting in targeted cancer cell elimination with reduced side effects. Future advancements include improved linker technology, novel cytotoxic agents, and integration with other therapies, making ADCs pivotal in modern medicine. View this paper
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Articles (579)

  • Article
  • Open Access
2 Citations
2,264 Views
11 Pages

Bolus Effect Caused by Use of Thermoplastic Masks in Head and Neck Radiotherapy Treatments

  • Diego A. Barajas-Lopez,
  • Cristian C. Castellanos-Jerez,
  • José A. Diaz-Merchan and
  • S. A. Martinez-Ovalle

22 August 2024

This paper examines the dosimetric uncertainty arising from the use of thermoplastic masks in the treatment of head and neck cancer through radiotherapy. This study was conducted through Monte Carlo simulations using the Monte Carlo N-Particle eXtend...

  • Article
  • Open Access
7 Citations
1,818 Views
19 Pages

Combined Multi-Omics Analysis Reveals the Potential Role of ACADS in Yak Intramuscular Fat Deposition

  • Fang Xu,
  • Haibo Wang,
  • Chunyu Qin,
  • Binglin Yue,
  • Youzhualamu Yang,
  • Jikun Wang,
  • Jincheng Zhong and
  • Hui Wang

22 August 2024

The Yak (Bos grunniens) is a special breed of livestock predominantly distributed in the Qinghai–Tibet Plateau of China. Intramuscular fat (IMF) content in beef cattle is a vital indicator of meat quality. In this study, RNA-Seq and Protein-Seq...

  • Article
  • Open Access
3 Citations
2,389 Views
13 Pages

Isolation and Characterization of a Novel Phage against Vibrio alginolyticus Belonging to a New Genus

  • Jie Gao,
  • Yuang Zhu,
  • Rui Zhang,
  • Juntian Xu,
  • Runjie Zhou,
  • Meiqi Di,
  • Di Zhang,
  • Wenxin Liang,
  • Xing Zhou and
  • Xing Ren
  • + 2 authors

22 August 2024

Vibrio alginolyticus causes substantial economic losses in the aquaculture industry. With the rise of multidrug-resistant Vibrio strains, phages present a promising solution. Here, a novel lytic Vibrio phage, vB_ValC_RH2G (RH2G), that efficiently inf...

  • Article
  • Open Access
3 Citations
2,129 Views
19 Pages

Shedding Light on Viral Shedding: Novel Insights into Nuclear Assembly, Cytoplasmic Transformation and Extracellular Vesicle Release of the BK Virus

  • Daniela Gerges,
  • Karim Abd El-Ghany,
  • Zsofia Hevesi,
  • Monika Aiad,
  • Haris Omic,
  • Clemens Baumgartner,
  • Wolfgang Winnicki,
  • Michael Eder,
  • Alice Schmidt and
  • Farsad Eskandary
  • + 1 author

22 August 2024

Despite the high prevalence of BK polyomavirus (BKPyV) and the associated risk for BKPyV-associated nephropathy (BKPyVAN) in kidney transplant (KTX) recipients, many details on viral processes such as replication, maturation, assembly and virion rele...

  • Article
  • Open Access
1,540 Views
18 Pages

22 August 2024

Quasipaa spinosa, commonly known as the spiny frog, is an economically valued amphibian in China prized for its tender meat and nutritional value. This species exhibits marked sexual dimorphism, most notably the prominent spiny structures on males th...

  • Article
  • Open Access
2 Citations
1,545 Views
18 Pages

Fungal Diversity and Gibberellin Hormones Associated with Long Whips of Smut-Infected Sugarcanes

  • Syeda Wajeeha Gillani,
  • Lixiu Teng,
  • Abdullah Khan,
  • Yuzhi Xu,
  • Charles A. Powell and
  • Muqing Zhang

22 August 2024

Sugarcane smut, caused by the fungus Sporisorium scitamineum (Sydow), significantly affects sugarcane crops worldwide. Infected plants develop whip-like structures known as sori. Significant variations in these whip lengths are commonly observed, but...

  • Article
  • Open Access
1,492 Views
18 Pages

Pitfalls When Determining HNA-1 Genotypes and Finding Novel Alleles

  • Kirstine Kløve-Mogensen,
  • Tom Browne,
  • Thure Mors Haunstrup and
  • Rudi Steffensen

22 August 2024

Genetic variation in the FCGR3B gene is responsible for different variants of human neutrophil antigen 1 (HNA-1). Laboratory techniques currently utilized for routine HNA-1 genotyping, predominantly PCR-sequence-specific primer (PCR-SSP) and PCR-sequ...

  • Review
  • Open Access
1 Citations
1,780 Views
24 Pages

22 August 2024

This review focuses on functional materials that contain terpyridine (terpy) units, which can be synthesized from biomass-derived platform chemicals. The latter are obtained by the chemical conversion of raw biopolymers such as cellulose (e.g., 2-fur...

  • Article
  • Open Access
5 Citations
2,280 Views
10 Pages

22 August 2024

Sirtuin 5 (SIRT5) is increasingly recognized as a key regulator of cellular metabolism, which is commonly dysregulated in cancer cells, resulting in enhanced proliferation and tumor progression. To investigate the clinicopathologic implications of SI...

  • Article
  • Open Access
6 Citations
1,738 Views
27 Pages

Integrative Analyses Reveal the Physiological and Molecular Role of Prohexadione Calcium in Regulating Salt Tolerance in Rice

  • Rui Deng,
  • Yao Li,
  • Nai-Jie Feng,
  • Dian-Feng Zheng,
  • You-Wei Du,
  • Aaqil Khan,
  • Ying-Bin Xue,
  • Jian-Qin Zhang and
  • Ya-Nan Feng

22 August 2024

Salinity stress severely restricts rice growth. Prohexadione calcium (Pro-Ca) modulation can effectively alleviate salt stress in rice. In this study, we explored the effects of Pro-Ca on enhancing salt tolerance in two rice varieties, IR29 and HD96-...

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Int. J. Mol. Sci. - ISSN 1422-0067