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International Journal of Molecular Sciences, Volume 24, Issue 18

September-2 2023 - 738 articles

Cover Story: The structures of histone complexes are master keys to epigenetics. A new protocol, PepGrow, has been introduced for the construction of histone complexes at atomic resolution. The docked histone fragments are used as seeds and the full peptide tails are grown in the binding pocket of the targeted reader proteins. The new protocol combines the advantages of popular program packages such as AutoDock and Modeller, allowing fast generation of complex structures. PepGrow handles the current challenges of structure determination of complexes of flexible and weakly bound peptide tails of histones. View this paper
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Articles (738)

  • Review
  • Open Access
18 Citations
7,688 Views
26 Pages

LOXL2 in Cancer: A Two-Decade Perspective

  • Amparo Cano,
  • Pilar Eraso,
  • María J. Mazón and
  • Francisco Portillo

21 September 2023

Lysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003, LOXL2 was first identified as a promoter of tumour progression and, over the...

  • Review
  • Open Access
10 Citations
3,728 Views
22 Pages

21 September 2023

Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous nature and high metastatic potential. The incidence of melanoma is continuously increasing worldwide, and it is one of the most common cancers in young adults. In t...

  • Review
  • Open Access
20 Citations
4,592 Views
11 Pages

Hepatocellular Carcinoma Prevention in the Era of Hepatitis C Elimination

  • Jeffrey V. Lazarus,
  • Camila A. Picchio and
  • Massimo Colombo

21 September 2023

The hepatitis C virus (HCV), a single-stranded RNA virus belonging to the Flaviviridae family, is a major cause of hepatocellular carcinoma (HCC) worldwide. Tumors caused by HCC have an increased mortality rate globally, which is more accentuated in...

  • Article
  • Open Access
6 Citations
2,560 Views
16 Pages

21 September 2023

Increased stemness is causally linked to the development of chemoresistance in cancers. B-cell receptor-associated protein 31 (BAP31) has been identified to play an oncogenic role in many types of cancer. However, the role of BAP31 in 5-fluorouracil...

  • Article
  • Open Access
17 Citations
2,951 Views
16 Pages

Biosynthesis of Bacterial Nanocellulose from Low-Cost Cellulosic Feedstocks: Effect of Microbial Producer

  • Ekaterina A. Skiba,
  • Nadezhda A. Shavyrkina,
  • Maria A. Skiba,
  • Galina F. Mironova and
  • Vera V. Budaeva

21 September 2023

Biodegradable bacterial nanocellulose (BNC) is a highly in-demand but expensive polymer, and the reduction of its production cost is an important task. The present study aimed to biosynthesize BNC on biologically high-quality hydrolyzate media prepar...

  • Article
  • Open Access
8 Citations
2,190 Views
17 Pages

Physiological and Morphological Implications of Using Composts with Different Compositions in the Production of Cucumber Seedlings

  • Anita Zapałowska,
  • Natalia Matłok,
  • Tomasz Piechowiak,
  • Małgorzata Szostek,
  • Czesław Puchalski and
  • Maciej Balawejder

21 September 2023

Compost has a broad application in terms of the improvement of the soil properties. This research work was conducted to present the molecular implications of using compost obtained from different substrates to improve soil parameters for cucumber see...

  • Article
  • Open Access
10 Citations
7,236 Views
10 Pages

Scopolamine-Induced Memory Impairment in Mice: Effects of PEA-OXA on Memory Retrieval and Hippocampal LTP

  • Carmela Belardo,
  • Serena Boccella,
  • Michela Perrone,
  • Antimo Fusco,
  • Andrea Maria Morace,
  • Federica Ricciardi,
  • Roozbe Bonsale,
  • Ines ELBini-Dhouib,
  • Francesca Guida and
  • Livio Luongo
  • + 3 authors

21 September 2023

Transient global amnesia, both persistent and transient, is a very common neuropsychiatric syndrome. Among animal models for amnesia and testing new drugs, the scopolamine test is the most widely used for transient global amnesia (TGA). This study ex...

  • Article
  • Open Access
17 Citations
4,344 Views
15 Pages

Transcriptome-Based WGCNA Analysis Reveals the Mechanism of Drought Resistance Differences in Sweetpotato (Ipomoea batatas (L.) Lam.)

  • Jikai Zong,
  • Peitao Chen,
  • Qingqing Luo,
  • Jilong Gao,
  • Ruihua Qin,
  • Chunli Wu,
  • Qina Lv,
  • Tengfei Zhao and
  • Yufan Fu

21 September 2023

Sweetpotato (Ipomoea batatas (L.) Lam.) is a globally significant storage root crop, but it is highly susceptible to yield reduction under severe drought conditions. Therefore, understanding the mechanism of sweetpotato resistance to drought stress i...

  • Review
  • Open Access
20 Citations
8,475 Views
20 Pages

21 September 2023

Liquid hydrogen carriers will soon play a significant role in transporting energy. The key factors that are considered when assessing the applicability of ammonia cracking in large-scale projects are as follows: high energy density, easy storage and...

  • Article
  • Open Access
19 Citations
3,241 Views
21 Pages

21 September 2023

The liver and ovary perform a vital role in egg production in hens. In the later laying period, the egg-laying capacity of female hens, particularly that of local breeds, declines significantly. Hence, it is essential to study the features and condit...

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Int. J. Mol. Sci. - ISSN 1422-0067