Special Issue "Proposal of a Special Issue On: Basic, Translational and Clinical Research on Dementia"

Dear Colleagues,

The global impact of dementia is increasingly worrisome and up to 90% of dementia patients in low- and middle-income countries is not diagnosed with further delays in diagnosis due to the pandemic during which these fragile population pays the highest price.

Alzheimer’s disease (AD) is the most common accounting for about two-thirds of all cases, but mixed forms of dementia are being increasingly recognized, making dementia a public health priority. These different forms may at least in part be explained through progressive alterations of the epigenome that may contribute to the decrease of cognitive abilities with advancing age.

Indeed, there is little doubt that AD is a multifactorial disease, which involves diverse pathogenic mechanisms and will probably require combinatorial therapies. Although many pathological factors, such as accumulation of protein aggregates of amyloid-beta (Aβ) and tau, have been identified, their role in combination with other factors, at different disease stages, requires further clarification. A comprehensive understanding of the complex disease mechanisms, the identification of early disease markers aided by ultrastructural magnetic resonance imaging are necessary to develop more effective treatments.

Although multiple failures of phase III trials with agents targeting Aβ had initially been disappointing, the accelerated approval of mAbs has recently renewed the interest in targeting Aβ. The gain of information from the real-world data on these neurotherapeutics may anticipate that further development of clinical trials in AD will be prompted.

Accordingly, we would like to invite contributions from basic, translational and clinical research on dementia in the form of original, narrative or systematic reviews on each of the above-named topics.

Prof. Dr. Giacinto Bagetta
Dr. Daniele Bano
Dr. Damiana Scuteri
Guest Editors

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• dementia
• Alzheimer’s disease
• amyloid-beta
• tau protein